Low energy nitrogen ion beam implanted tungsten trioxide thin films modified indium tin oxide electrode based acetylcholine sensor

Anithaa, A.C.; Asokan, K.; Sekar, C.

doi:10.1016/j.jtice.2018.01.001

Cited by 17 publications

(3 citation statements)

References 36 publications

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“…The same authors demonstrated that the irradiation of WO 3 with low energy nitrogen ion beam (fluences: 1 × 10 14 to 1 × 10 17 ions/cm 2 ) and swift heavy ion [Ni 11+ ] enabled the detection of acetylcholine [ 159 ] and guanine [ 160 ] with high precision and improved selectivity. In all the cases, WO 3 NPs surface modification through irradiation seems to enhance the sensitivity, linear range and selectivity.…”

Section: An Overview On Mox Nanomaterials Used For Biosensing Detementioning

confidence: 99%

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Fazio

Spadaro

Corsaro

et al. 2021

Sensors

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Pure, mixed and doped metal oxides (MOX) have attracted great interest for the development of electrical and electrochemical sensors since they are cheaper, faster, easier to operate and capable of online analysis and real-time identification. This review focuses on highly sensitive chemoresistive type sensors based on doped-SnO2, RhO, ZnO-Ca, Smx-CoFe2−xO4 semiconductors used to detect toxic gases (H2, CO, NO2) and volatile organic compounds (VOCs) (e.g., acetone, ethanol) in monitoring of gaseous markers in the breath of patients with specific pathologies and for environmental pollution control. Interesting results about the monitoring of biochemical substances as dopamine, epinephrine, serotonin and glucose have been also reported using electrochemical sensors based on hybrid MOX nanocomposite modified glassy carbon and screen-printed carbon electrodes. The fundamental sensing mechanisms and commercial limitations of the MOX-based electrical and electrochemical sensors are discussed providing research directions to bridge the existing gap between new sensing concepts and real-world analytical applications.

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Section: An Overview On Mox Nanomaterials Used For Biosensing Detementioning

confidence: 99%

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Fazio

Spadaro

Corsaro

et al. 2021

Sensors

View full text Add to dashboard Cite

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“…Detection of local pH changes (using a potentiometric pH sensor on an electrode with immobilized AChE) has also been reported as an alternative readout method [ 37 , 38 ]. Different nanomaterials have been proposed to replace the enzymes and catalyze the electrochemical reaction of ACh at the electrode surface [ 39 , 40 , 41 , 42 , 43 , 44 ]. Limited specificity remains a concern for this type of sensor [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

FAST (Flexible Acetylcholine Sensing Thread): Real-Time Detection of Acetylcholine with a Flexible Solid-Contact Potentiometric Sensor

Amirghasemi,

Soleimani,

Bawarith

et al. 2023

Bioengineering

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Acetylcholine (ACh) is involved in memory and learning and has implications in neurodegenerative diseases; it is therefore important to study the dynamics of ACh in the brain. This work creates a flexible solid-contact potentiometric sensor for in vitro and in vivo recording of ACh in the brain and tissue homogenate. We fabricate this sensor using a 250 μm diameter cotton yarn coated with a flexible conductive ink and an ACh sensing membrane that contains a calix[4]arene ionophore. The exposed ion-to-electron transducer was sealed with a 2.5 μm thick Parylene C coating to maintain the flexibility of the sensor. The resulting diameter of the flexible ACh sensing thread (FAST) was 400 μm. The FAST showed a linear response range from 1.0 μM to 10.0 mM in deionized water, with a near-Nernstian slope of 56.11 mV/decade and a limit of detection of 2.6 μM. In artificial cerebrospinal fluid, the limit of detection increased to 20 μM due to the background signal of ionic content of the cerebrospinal fluid. The FAST showed a signal stability of 226 μV/h over 24 h. We show that FAST can measure ACh dynamics in sheep brain tissue and sheep brain homogenate after ACh spiking. FAST is the first flexible electrochemical sensor for monitoring ACh dynamics in the brain.

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“…Over the past decade, development of electrochemical non-enzymatic ACh biosensors has risen at considerable rate for ACh detection. The advantages include simple design, cost effectiveness, good stability and effective enzyme-like catalysis against temperature and pH [18].…”

Section: Introductionmentioning

confidence: 99%

Nonenzymatic coated screen-printed electrode for electrochemical determination of acetylcholine

Mohammadi

Beitollahi

Tajik

2018

Micro and Nano Syst Lett

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In the present study, a screen-printed electrode based-sensor with electrochemical detection was developed for rapid and sensitive determination of acetylcholine. At first, the screen-printed carbon electrode was modified by using a magnetic core shell and then was used for voltammetric determination of acetylcholine in ampoule, serum and urine samples. The electrochemical behaviour of acetylcholine at the modified electrode was investigated by cyclic voltammetry. The modified electrode displayed a decrease in the overpotential (ca. 130 mV) and an obvious increase in the peak current compared to the non-modified screen-printed electrode. The results indicated that modified screenprinted electrode enhanced electrocatalytic activity towards the oxidation of acetylcholine. Under optimized conditions, the limit of detection from the experiment of acetylcholine determination was 0.02 µM with acetylcholine concentration in range of 0.1-500.0 µM. The reproducibility of the measurements was tested by recording the responses for 50.0 µM acetylcholine with four different developed sensors prepared on the same manner and the same day. A relative standard deviation value of 4.3% was obtained. Finally, a recovery test is done as a part of accuracy evaluation of the system. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Low energy nitrogen ion beam implanted tungsten trioxide thin films modified indium tin oxide electrode based acetylcholine sensor

Cited by 17 publications

References 36 publications

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

Metal-Oxide Based Nanomaterials: Synthesis, Characterization and Their Applications in Electrical and Electrochemical Sensors

FAST (Flexible Acetylcholine Sensing Thread): Real-Time Detection of Acetylcholine with a Flexible Solid-Contact Potentiometric Sensor

Nonenzymatic coated screen-printed electrode for electrochemical determination of acetylcholine

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