Low dose X-radiation and acrocentric chromosome satellite associations in human lymphocytes

Stenstrand, K

doi:10.1111/j.1601-5223.1978.tb01613.x

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Only a few studies are available on the doseeffect relationship between ACA and radiation exposure. For the rst time, the effect of low dose X-irradiation on acrocentric chromosome satellite associations was studied and observed that irradiation may in uence the composition of the satellite association complexes, however, results were inconsistent [29]. In another study, an increase in acrocentric association with increase of radiation dose was reported for 0-1 Gy radiation exposure, however, exposure to 1-4 Gy showed an inverse relation with dose [30].…”

Section: Discussionmentioning

confidence: 99%

Linear Dose Response of Acrocentric Chromosome Associations (Aca) To Gamma Irradiation In Human Lymphocytes

Samarth¹,

Gandhi²,

Chaudhury³

2021

Preprint

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Purpose: The frequency of acrocentric chromosome associations (ACA) was studied to determine the possible dose-response relation with low doses of gamma irradiation in lymphocytes. Methods: Peripheral blood collected from three healthy donors were irradiated with 0, 0.1, 0.25, 0.5, 0.75, and 1 Gy gamma radiation. Chromosomal preparations were made after 48 hrs culture as per the standard guidelines. Results: The average number of ACA and ACA % were increased significantly with an increase in a dose. The D-G and D-D type of association was most prominent and showed a dose-dependent increase. The ACA frequency in irradiated lymphocytes showed an increase concerning the dose. The fitted regression equation was y=0.4759x+0.1663 (R2=0.9635; p=0.0005). An assessment of dicentric chromosomes (DC) was carried for the same slides. The correlation curve was prepared for ACA frequencies versus DC frequencies, resulting in a regression equation as y=8.659x+0.2.37 (R2=0.8275; p=0.0119). Conclusion: Our results showed an increase in frequencies of ACA in irradiated lymphocytes with an increase in radiation dose and followed a similar linear trend with DC frequency, thus, ACA may serve as a candidate cytogenetic biomarker for radiation biodosimetry especially for low radiation doses.

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Section: Discussionmentioning

confidence: 99%

Linear Dose Response of Acrocentric Chromosome Associations (Aca) To Gamma Irradiation In Human Lymphocytes

Samarth¹,

Gandhi²,

Chaudhury³

2021

Preprint

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The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

Lernia

Crimaudo

Pacchetti³

1982

Hum Genet

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Satellite associations were used as parameters to test nucleolar organizer activity. Assuming that toxic and/or mutagenic agents may affect the ribosomal genes, satellite associations in human lymphocytes were analysed following exposure to X-rays and compared with the satellite association pattern of subjects exposed to TCDD. A significant decrease in the satellite association frequency in D group chromosomes was found both in irradiated lymphocytes and in subjects exposed to Dioxin. The findings seem to be in accordance with the hypothesis based on random damage of functional nucleolar organizing regions.

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Linear dose response of acrocentric chromosome associations to gamma irradiation in human lymphocytes

2022

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Low dose X-radiation and acrocentric chromosome satellite associations in human lymphocytes

Cited by 5 publications

References 10 publications

Linear Dose Response of Acrocentric Chromosome Associations (Aca) To Gamma Irradiation In Human Lymphocytes

Linear Dose Response of Acrocentric Chromosome Associations (Aca) To Gamma Irradiation In Human Lymphocytes

The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

Linear dose response of acrocentric chromosome associations to gamma irradiation in human lymphocytes

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