The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

Lernia, R. Di; Crimaudo, C.; Pacchetti, G.

doi:10.1007/bf00291330

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…This phenomenon was associated with the possible shorter lifetime of the lymphocytes, rather than with the change of the active rRNA genes copy number (this study group was characterized by the highest copy number of the active rRNA genes). For these reasons, we think it groundless to consider the associative ability as the universal parameter reflecting the rRNA gene activity, as it was done in some population studies [18].…”

Section: Discussionmentioning

confidence: 98%

Genomic dosages of active rRNA genes in coke-oven workers

Минина

Дружинин

2004

Russ J Genet

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Genomic dosage (copy number) of active ribosomal genes was evaluated using visual semi-quantitative method determining the sizes of Ag-NORs in acrocentric chromosomes after selective silver nitrate staining. A relationship between the length of service and the active ribosomal gene copy number was established: the highest numbers of active rRNA genes were observed in coke-oven workers with a length of service exceeding 20 years. An inverse relationship between the individual doses of active ribosomal genes and toxicogenetic susceptibility of the workers to the occupational factors was also revealed.

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Section: Discussionmentioning

confidence: 98%

Genomic dosages of active rRNA genes in coke-oven workers

Минина

Дружинин

2004

Russ J Genet

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Mercury chloride- and methyl mercury chloride-induced inhibition in NOR activity

Verschaeve

Kirsch‐Volders

Susanne

1983

Teratog. Carcinog. Mutagen.

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Previous work has raised the question of whether mercury compounds inhibit the activity of the nucleolar organizing genes. For that reason we performed a cytophotodensitometric analysis on silver-stained interphase nuclei from human peripheral blood lymphocytes exposed to various concentrations of HgCl2 (0-150 X 10(-6) M), CH3HgCl (0-50 X 10(-6) M), and actinomycin D (0-0.1 microgram/ml). The last compound was used as a positive control. The cells were exposed to the compounds either during G1-early S phase, allowing recovery after the exposure, or from G1 until harvest; thus no recovery was allowed in this case. Like actinomycin D, both mercury compounds were shown to inhibit the NOR activity. This inhibition was furthermore more evident during the short exposure experiment. Our results do confirm that mercury compounds may, to a certain extent, influence some factors regulating the nucleolus-organizing activity.

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Does agent orange cause birth defects?

Friedman

1984

Teratology

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Large quantities of the defoliant, Agent Orange, were sprayed in Vietnam during the war. Agent Orange was composed of two herbicides: 2,4-D and 2,4,5-T, the latter contaminated by small amounts of a highly toxic dioxin (TCDD). The constituents of Agent Orange are capable of producing gene mutations and chromosomal aberrations, at least in some experimental circumstances. TCDD and 2,4,5-T are teratogenic in mice and perhaps in other mammals, but the teratogenicity of these chemicals has not been convincingly demonstrated in humans. There is currently no scientific evidence which indicates that men who were previously exposed to Agent Orange are at increased risk of having children with birth defects, but available data are inadequate to assess this possibility critically.

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The study of X-rays and TCDD effects on satellite associations may suggest a simple model for application in environmental mutagenesis

Cited by 9 publications

References 25 publications

Genomic dosages of active rRNA genes in coke-oven workers

Genomic dosages of active rRNA genes in coke-oven workers

Mercury chloride- and methyl mercury chloride-induced inhibition in NOR activity

Does agent orange cause birth defects?

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