Low-dose isotretinoin therapy and blood lipid abnormality: A case series with sixty patients

Sarkar, Tanusree; Sarkar, Sonali; Patra, Aparesh Chandra

doi:10.4103/jfmpc.jfmpc_104_16

Cited by 10 publications

(15 citation statements)

References 17 publications

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“… 34 Furthermore, a very small number of patients (34) experienced hyperlipidemia while on isotretinoin treatment, which is much lower compared to other studies. 35 These low findings are attributed to most of our sample being young females (96%), and females generally are at lower risk of developing hypercholesterolemia. 36 Moreover, as shown in Table 7 , the lack of regular monitoring might have affected this finding.…”

Section: Discussionmentioning

confidence: 74%

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Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

Abukhalil,

Yousef,

Ammar

et al. 2024

PPA

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Background Isotretinoin is a commonly prescribed medication for the treatment of acne. It is associated with serious side effects that require monitoring and adherence by patients and healthcare providers. No studies have been conducted in Palestine to explore isotretinoin prescribing and utilization. Objective This study aims to evaluate the current clinical practices, adherence to clinical guidelines, efficacy, and reported side effects associated with Isotretinoin treatment in Palestine. Methods A descriptive cross-sectional online questionnaire-based study using social media platforms (eg, Facebook and Telegram) was conducted among Birzeit University students in April 2023. This study included participants aged ≥ 18 years with a history of isotretinoin treatment; subjects with incomplete data were excluded. Statistical significance was set at P < 0.05. SPSS version 27 was used for data analysis. Results A total of 548 participants were included in the study, the majority of most of whom were female (96%). The most predominant side effects were cracked, dry lips and xeroderma (96.2%). Moreover, 12% of participants had depression. Most respondents were educated about medication side effects and only 39.1% were counseled about blood donation. Of the 59 sexually active women, only 4 (6.8%) were asked for a recent pregnancy test. A total of 60.2% of dermatologists adhered to the American Academy of Dermatology (AAD) guidelines, and 48.7% ordered the required laboratory tests before initiating isotretinoin treatment. Only 1.7% of pharmacists followed the FDA-suggested protocols for dispensing isotretinoin to childbearing females. Conclusion Adherence to isotretinoin safety prescribing protocols to provide patient education, monitoring, and ordering of laboratories to ensure patient safety can be improved by adapting policies and protocols in pharmacy and medical practice in Palestine to monitor and enforce adherence when prescribing, dispensing, or taking high-risk medications.

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Section: Discussionmentioning

confidence: 74%

“… 28 , 40 However conclusive evidence supports the claim that acne relapse is higher in males or females, specifically post isotretinoin therapy. 35 …”

Section: Discussionmentioning

confidence: 99%

Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

Abukhalil,

Yousef,

Ammar

et al. 2024

PPA

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“…ese recommendations were affirmed with a later study as the results were consistent with what has been found previously, that is, variable increase in several lipid profiles when a low-dose isotretinoin was administrated by the patients. is work also emphasized on continuous monitoring of lipid profile, especially in patient with risk factors of metabolic syndrome [37]. A recent study showed that a slight-to-modest increase of lipid and liver enzyme levels always occurs when isotretinoin is taken.…”

Section: Discussionmentioning

confidence: 99%

The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients

Garba

Khabour

Alzoubi

et al. 2020

Dermatology Research and Practice

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Background. Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment. Aim. In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230). Methods. Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients. Results. Alterations in lipid profile with a significant increase of ALT (P=0.007) were detected after isotretinoin treatment. Moreover, percentage change in HDL following isotretinoin treatment was significantly associated with rs1501299 (P=0.008). On the other hand, no associations between examined SNPs and side effects of isotretinoin and other lipid parameters (total cholesterol, LDL, and triglycerides) or liver function enzymes (ALT and AST) were detected. Conclusions. Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.

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“…3.1 | Low-dose isotretinoin therapy and blood lipid abnormality Sarkar et al noted that among 60 patients on low-dose isotretinoin for relevant indications, hyperlipidemia was present in 25% of the patients only. Among the hyperlipidemia, hypertriglyceridemia was the commonest (Sarkar, Sarkar, & Patra, 2018). Administration of 1 g/day omega-3 may be hence plausible with its well-known efficacy in lowering hypertriglyceridemia (Mirnezami & Rahimi, 2018).…”

Section: Safety Of Low-dose Isotretinoinmentioning

confidence: 99%

Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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Isotretinoin is a first‐generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti‐inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date‐unlimited PubMed search, from inception till December 2019, using the following search terms: “low‐dose isotretinoin” and “dermatology,” “isotretinoin and safety,” “isotretinoin, off‐label uses,” “isotretinoin and male fertility,” “isotretinoin, iPLEDGE system,” aiming to deliver a therapeutic update relevant to clinical practice. All English‐language articles were considered with no limitation based on the articles' type. Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.

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Low-dose isotretinoin therapy and blood lipid abnormality: A case series with sixty patients

Cited by 10 publications

References 17 publications

Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients

Low dose of isotretinoin: A comprehensive review

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