“…Isotretinoin earliest clinical response usually is observed after 4-6 weeks of therapy (Agarwal, Besarwal, & Bhola, 2011;Izol, Başkan, Başar, Tunali, & Saricao glu, 2012). For the last three decades, it has been observed through animal model studies that isotretinoin therapy can alter several functions of innate immunity during this period of a clinical trial, and many studies were performed, although with varying reported results for both animal models and human (Holland, Gallon, & Cunliffe, 1984;McKerrow, Mackie, Lesko, & Pearson, 1988).…”