Low Dose Intermittent Isotretinoin Therapy in Moderate Acne Vulgaris

İzol, Belçin; Başkan, Emel Bülbül; Basar, Zubeyde; Tunali, Şükran; Sarıcaoğlu, Hayriye

doi:10.5152/tdd.2012.02

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Isotretinoin earliest clinical response usually is observed after 4-6 weeks of therapy (Agarwal, Besarwal, & Bhola, 2011;Izol, Başkan, Başar, Tunali, & Saricao glu, 2012). For the last three decades, it has been observed through animal model studies that isotretinoin therapy can alter several functions of innate immunity during this period of a clinical trial, and many studies were performed, although with varying reported results for both animal models and human (Holland, Gallon, & Cunliffe, 1984;McKerrow, Mackie, Lesko, & Pearson, 1988).…”

Section: Antimicrobial Peptides Play a Dual Role In Acne Vulgaris Thmentioning

confidence: 99%

Downregulation of S100a7a antimicrobial peptide in acne vulgaris patients after isotretinoin therapy

Al‐Sudany¹,

Mohammed

Alrifai³

2019

Dermatologic Therapy

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The S100a7a protein is expressed in keratinocytes, its level is increased in acne condition. As isotretinoin therapy is known to alter some of S100 peptides, these could be important specific targets for acne therapy and may have an important role in clinical remission. A randomized controlled trial was held in a dermatology clinic in Baghdad, where 30 patients with moderate to severe acne vulgaris condition aged 16–31 years were enrolled. Five milliliters of venous blood samples were taken before and after 6 weeks of isotretinoin therapeutic trial. A placebo‐control group of 26 acne patients was also enrolled. The S100a7a peptide was measured in both groups using the ELISA technique before and after the trial. High levels of serum S100a7a were found in acne patients of both groups before therapeutic trial. Following the trial, a significant statistical difference (p = .0003) was noticed between mean S100a7a protein level of study and control groups. By comparing the mean S100a7a protein level before and after isotretinoin therapy in the study group, a highly significant statistical difference was also found (p = .001). The current study showed a downregulatory effect of isotretinoin therapy on the S100a7a peptide mean level.

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