The S100a7a protein is expressed in keratinocytes, its level is increased in acne condition. As isotretinoin therapy is known to alter some of S100 peptides, these could be important specific targets for acne therapy and may have an important role in clinical remission. A randomized controlled trial was held in a dermatology clinic in Baghdad, where 30 patients with moderate to severe acne vulgaris condition aged 16–31 years were enrolled. Five milliliters of venous blood samples were taken before and after 6 weeks of isotretinoin therapeutic trial. A placebo‐control group of 26 acne patients was also enrolled. The S100a7a peptide was measured in both groups using the ELISA technique before and after the trial. High levels of serum S100a7a were found in acne patients of both groups before therapeutic trial. Following the trial, a significant statistical difference (p = .0003) was noticed between mean S100a7a protein level of study and control groups. By comparing the mean S100a7a protein level before and after isotretinoin therapy in the study group, a highly significant statistical difference was also found (p = .001). The current study showed a downregulatory effect of isotretinoin therapy on the S100a7a peptide mean level.
Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin
enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2.
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