Low-dose interferon-α treatment for feline immunodeficiency virus infection

“…When IFN-I is administered to HIV-, simian immunodeficiency virus (SIV)-, or feline immunodeficiency virus (FIV)-infected individuals clinical signs are seen to improve [30, 33, 60, 106, 117], supporting the hypothesis that type I IFNs play important roles in the response to these retroviruses, as well as to other retroviruses, such as HTLV-I [46, 79, 117], BLV [78], feline leukemia virus (FeLV) [28, 149], or MuLV [2, 52]. …”

Section: Interferonmentioning

confidence: 99%

Effect of Type-I Interferon on Retroviruses

Gómez-Lucı́a

Collado

Miró

et al. 2009

Viruses

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Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates apoptosis. IFN-I not only affect the immune system, but also operate directly on virus replication. Most data suggest that the in vitro treatment with IFN-I of retrovirus infected cells inhibits the final stages of virogenesis, avoiding the correct assembly of viral particles and their budding, even though the mechanism is not well understood. However, in some retroviruses IFN-I may also act at a previous stage as some retroviral LTRs posses sequences homologous to the IFN-stimulated response element (ISRE). When stimulated, ISREs control viral transcription. HIV-1 displays several mechanisms for evading IFN-I, such as through Tat and Nef. Besides IFN-α and IFN-β, some other type I IFN, such as IFN-τ and IFN-ω, have potent antiviral activity and are promising treatment drugs.

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“…Захисна дія людського рекомбінантного інтерферону альфа була показана у дослідах з експеримен-тальним зараженням тварин вірусом лейкемії котів при пероральному уведенні [20,115] та зараженням вірусом імунодефіциту котів при ін'єкційному уведенні [91].…”

Section: The Information About the Use Of Interferons In Veterinary Munclassified

Interferons: application in veterinary medicine

Oksamytnyi¹

2017

Bìol. Tvarin

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Low-dose interferon-α treatment for feline immunodeficiency virus infection

Cited by 40 publications

References 22 publications

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Efficacy of antiviral chemotherapy for retrovirus-infected cats

Effect of Type-I Interferon on Retroviruses

Interferons: application in veterinary medicine

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