Interferons: application in veterinary medicine

Oksamytnyi, V. M.

doi:10.15407/animbiol19.03.055

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…У практиці ветеринарної медицини для посилення імунної системи використовують інтерферон (Stravskyi & Stravska, 2013;Oksamytnyi, 2017). Інтерферон як один з ключових чинників захисних механізмів імунної системи тварин проявляє свій вплив завдяки системній дії на організм за умов різних негативних чинників (Kramariev & Yevtushenko, 2019).…”

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Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Lavryshyn,

Gutyj,

Verveha

et al. 2023

SMLNUVMB

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The research aimed to determine the acute toxicity and cumulative properties of the liposomal drug “Lipointersil” based on interferon and spotted milk thistle. The acute toxicity of the “Lipointersil” drug was assessed in white rats, aged 2–3 months, with a body weight of 170–180 g through intragastric and intramuscular administration. After administration of the drug, the dose and the number of animals that died were recorded, and the median lethal dose (DL50) of the investigated drug was calculated using the method of H. Kerber. The cumulative properties were determined in white rats aged 2–3 months, weighing 170–185 g, using the subchronic toxicity test method by K. S. Lim et al., modified by K. K. Sydorov. Based on the conducted research, it was established that the “Lipointersil”drug, according to the State Standard of Ukraine 85.2-37-736:2011, belongs to class IV toxicity (slightly toxic substances). The LD50 for intragastric and intramuscular administration in white rats is 5166.66 and 5833.33 mg/kg of body weight, respectively. In determining of the cumulative properties of the “ Lipointersil ” drug, no deaths of experimental animals were observed during the study. Moreover, the animals remained active, fed well, and had dense, shiny fur. The coefficient of accumulation of the “Lipointersil” drug was more than 8.31 units, indicating its weakly pronounced cumulative properties. Prolonged daily administration for 24 days of “Lipointersil” had no significant impact on the functional state of the liver and kidneys. Under long-term (24 days) daily administration in increasing doses, the drug “Lipointersil” caused slight destruction of hepatocyte membranes, as indicated by the increased activity of alanine and aspartate aminotransferases and alkaline phosphatase.

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Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Lavryshyn,

Gutyj,

Verveha

et al. 2023

SMLNUVMB

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Interferons-α and -γ in clinical veterinary practice in the prevention and treatment of infectious diseases in cattle and pigs (review)

Shabunin

Востроилова

Grigoryeva

et al. 2022

Аграрная наука Евро-Северо-Востока

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The review article analyzes the existing world experience in the use of interferons IFN-α and -γ as well as drugs based on them in clinical veterinary practice in cattle and pigs. The selection of literary sources was carried out on the basis of their relevance and the depth of the research (search retrospectiveness is 30 years). It has been established that IFNs are widely used in the prevention and treatment of both infectious and non-infectious diseases, which can be divided into 3 groups: viral infections, oncological diseases, bacterial and aseptic diseases. The use of IFNs is due to their antiviral activity and immunoregulatory effect. Thus, IFN-α exhibits antiviral activity and is the first line of nonspecific immune defense, an inducer of IFN-γ synthesis and the main coordinator of the body's successful response to a viral infection. At the same time, IFN-γ provides immunoregulatory, anti-inflammatory and mediated antibacterial action by stimulating the production of macrophages and participating in the differentiation of lymphocytes. Clinical efficacy is expressed in a decrease or cessation of the infectious process, a decrease in leukocytosis and neutrophilia, relief of acidotic syndrome, an increase in the body weight of animals and an improvement in the general clinical condition. Currently, IFN therapy is one of the most promising and constantly expanding areas of immunopharmacology and treatment of common respiratory, gastrointestinal, obstetric-gynecological diseases in farm animals.

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Interferons: application in veterinary medicine

Abstract: Державна наукова установа «Державний центр інноваційних біотехнологій», вул. Донецька, 30, м. Київ, 03151, Україна, dnu.cib@ukr

Cited by 2 publications

References 69 publications

Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Interferons-α and -γ in clinical veterinary practice in the prevention and treatment of infectious diseases in cattle and pigs (review)

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