Low‐Cost Pulsatile Cardiac Assist Device With Compliant Input Chamber

Cañizo, Juan del; Rodríguez–Martínez, Daniel; Pérez–Caballero, Ramón; Aramayona, Begoña; Ruiz-Fernandez, Manuel

doi:10.1111/j.1525-1594.2009.00762.x

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Juan del Cañizo et al. (24) of the Hospital General Universitario Gregorio Marañon, Madrid, Spain proposed a new, low‐cost pulsatile VAD for short‐term applications. The device allows ventricular function to be maintained as the patient's situation is evaluated and a decision is made on whether to perform a heart transplant or to replace the device with a long‐term VAD.…”

Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2010: A Year in Review

Malchesky¹

2011

Artificial Organs

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In this Editor's Review, articles published in 2010 are organized by category and briefly summarized. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level."Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide such meaningful suggestions to the author's work whether eventually accepted or rejected and especially to those whose native tongue is not English. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, Wiley-Blackwell, for their expert attention and support in the production and marketing of Artificial Organs. In this Editor's Review, that historically has been widely received by our readership, we aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ Replacement, Recovery, and Regeneration. We look forward to recording further advances in the coming years.

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Section: Cardiac Support and Blood Pumpsmentioning

confidence: 99%

Artificial Organs 2010: A Year in Review

Malchesky¹

2011

Artificial Organs

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Changes in cerebral blood flow in two different pulsatile ventricular assist devices: Experimental study in pigs

Rodríguez-Bernal

Sanchez

Heredero

et al. 2011

European Journal of Anaesthesiology

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Background and Goal of Study: Cardiopulmonary bypass (CPB) is associated with a transition of pulsatile to non-pulsatile flow generated by the heart-lung machine. Non-pulsatile flow may deteriorate postoperative organ perfusion, but this has only scarcely been investigated on a microcirculatory level. We therefore hypothesized that non-pulsatile flow negatively influences microcirculatory perfusion in cardiac surgery, and this is prevented by pulsatile flow during ex tracorporeal circulation. Materials and Methods: Patients undergoing coronary artery bypass graf t (CABG) surgery were randomized into a non-pulsatile (n=15) or pulsatile (n=15) CPB group. Sublingual mucosal microvascular function was measured at preoperative, intraoperative and postoperative time points using sidestream dark field imaging and quantified as the level of perfused vessel density (PVD) and microvascular flow index (MFI). Microcirculation measurements were paralleled by hemodynamic and inflammatory parameter analysis. Results and Discussion: The observed reduction in PVD during aorta crossclamping was only restored in the pulsatile flow group and increased from 15.5±2.4 mm/mm 22 upon intensive care unit admission (P< 0.01). The median postoperative MFI was higher in the pulsatile group (2.8 (2.7-2.9)) than in the non-pulsatile group (2.5 (1.9-2.7); P< 0.05). There was no association of preserved microcirculatory vessel perfusion with inflammatory parameters. Pulsatile flow was associated with improved oxygen consumption from 71±14 to 85±14 ml/min/m 2 (P< 0.05) during aorta cross-clamping, which was not found for non-pulsatile flow. to 20.3±3.7 mm/mm Conclusion: Pulsatile CPB preserves microcirculatory perfusion throughout the early postoperative period. Improved oxygen consumption during pulsatile flow suggests decreased microcirculatory shunting during CPB, which may contribute to the observed preservation of microcirculatory function in the perioperative period.

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