Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers

Kryger, Meir H.; Otake, Kazuo; Foerster, John

doi:10.1016/s1389-9457(01)00160-5

Cited by 104 publications

(57 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[10][11][12][13] However, only a small number of studies have evaluated RLS in the adolescent population, and fewer have assessed RLS and its correlates including quality of life in community pediatric populations. The aim of this study is to investigate the prevalence of symptoms consistent with RLS in a community sample of adolescents and young BRIEF SUMMARY Current Knowledge/Study Rationale: Clinical reports in children implicate restless legs syndrome (RLS) with sleep and behavior problems.…”

mentioning

confidence: 99%

“…8 Subjects with RLS reported signifi cant defi cits in health-related quality of life when compared to subjects with In children, RLS has been associated with attention defi cit hyperactivity disorder (ADHD), growing pains, behavioral disorders, and low ferritin levels. [10][11][12][13] However, only a small number of studies have evaluated RLS in the adolescent population, and fewer have assessed RLS and its correlates including quality of life in community pediatric populations. The aim of this study is to investigate the prevalence of symptoms consistent with RLS in a community sample of adolescents and young…”

mentioning

confidence: 99%

See 1 more Smart Citation

Restless Legs Syndrome, Sleep, and Quality of Life among Adolescents and Young Adults

Silva

Goodwin

Vana

et al. 2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Objective: Clinical reports in children implicate restless legs syndrome (RLS) with sleep and behavior problems. However, population-based studies on this association in adolescents and young adults are limited. Furthermore, few studies have evaluated the association between symptoms consistent with RLS and quality of life (QoL). Study Design: This cross-sectional study included 214 Caucasian and Hispanic adolescents and young adults aged 12-20 years. Symptoms consistent with RLS were based on four essential criteria and if the symptoms occurred ≥ 5 days/ month. Trouble falling asleep was present if reported "yes, still have the problem." Quality of life (QoL) was assessed using the Pediatric QoL Inventory. Three summary QoL scores ranging from 0-100 were evaluated; higher scores indicated better QoL. Results: Participants were 50% male and 68.1% Caucasian. Prevalence of RLS was 8.4% (n = 18). RLS was associated with trouble falling asleep (OR = 3.1, p = 0.049), and trouble falling asleep was associated with worse Psychosocial Health scores (Coeff. −5.6, p = 0.004) and Total Scale scores for quality of life (Coeff. −4.6, p = 0.007). Conclusions:The prevalence of symptoms consistent with RLS in this community-based sample of adolescents and young adults, aged 12-20, is comparable to rates reported in older cohorts. Symptoms consistent with RLS may be associated with trouble falling asleep and psychosocial distress that may contribute to a lower health-related quality of life. S C I E N T I F I C I N V E S T I G A T I O N SR estless legs syndrome (RLS) is defi ned as a sensorimotor disorder that can have a pronounced disturbance on sleep with symptom severity ranging from mild and occasional to nightly and severe with complete disruption of sleep. Four essential criteria have been identifi ed and are required for the identifi cation of RLS.1 These are: (1) an urge to move the legs often accompanied by unpleasant sensations; (2) the urge is worsened during rest or inactivity; (3) the urge is improved with leg movement; and (4) the urge is worsened in the evening or night. The prevalence of RLS in adults is approximately 10% and has been associated with iron defi ciency, pregnancy, end-stage renal disease, and family history of RLS.2,3 RLS was fi rst described in children by Walters in 1994, 4 and the prevalence of RLS has been reported to be between 2% and 6%, 5,6 although relatively few studies of RLS have been conducted in the pediatric and adolescent populations. In adults, RLS has been associated with depression.7 However, little information is available on the impact of RLS on quality of life. In one study, RLS was found to have a signifi cant impact on health-related quality of life, measured using the SF-36 (Medical Outcomes Study 36-Item Short Form health survey), in 85 adult subjects with RLS as compared to 2,474 subjects from the general population.8 Subjects with RLS reported signifi cant defi cits in health-related quality of life when compared to subjects with hypertension, cardiovascular conditions...

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Restless Legs Syndrome, Sleep, and Quality of Life among Adolescents and Young Adults

Silva

Goodwin

Vana

et al. 2014

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

show abstract

“…Other studies have focused on the utility of iron supplementation in ADHD, with confl icting results (Sever et al 1997). Serum ferritin level is related to RLS severity (Krieger and Schroeder 2001), and since most of the subjects with iron defi ciency do not have anemia, low serum or cerebro-spinal fl uid ferritin levels may be the only signifi cant parameter (Sun et al 1998;Kryger et al 2002;Mizuno et al 2005). Thus, it has been recommended that serum ferritin level must be evaluated in every RLS subject (Trenkwalder et al 2005).…”

mentioning

confidence: 99%

Association between Low Serum Ferritin and Restless Legs Syndrome in Patients with Attention Deficit Hyperactivity Disorder

Öner¹,

Dirik²,

Taner

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Attention defi cit hyperactivity disorder (ADHD) is a neurobehavioral disorder characterized by pervasive inattention and/or hyperactivity-impulsivity. It has been suggested that ADHD symptoms are associated with restless legs syndrome (RLS), which is a neurological condition that is defi ned by an irresistible urge to move the legs. Increasing evidence suggests iron deficiency may underlie common pathophysiological mechanisms in subjects with ADHD and with RLS. To further defi ne the relationship between iron defi ciency and RLS in children and adolescents with ADHD, we evaluated 87 ADHD subjects: 79 boys and 8 girls with age 9.3 ± 2.5 years (6-16 years). Various psychopathologies and the severity of the ADHD symptoms and serum ferritin levels were assessed. Diagnosis of RLS was made according to the International RLS Group criteria. The patients were evaluated for the iron defi ciency (ferritin < 12 ng/ml). RLS was found in 29 (33.3%) of the 87 ADHD subjects. Parentand teacher-rated behavioral and emotional problems and the severity of ADHD symptoms were not signifi cantly different between ADHD subjects with RLS and those without RLS (n = 58). The rate of iron defi ciency was signifi cantly higher in ADHD subjects with RLS (n = 6, 20.7%) when compared with ADHD subjects without RLS (n = 1, 1.7%, p = 0.005). Our results showed that depleted iron stores might increase the risk of having RLS in ADHD subjects. Iron defi ciency, which is associated with both ADHD and RLS, seems to be an important modifying factor in the relationship between these two conditions. restless legs syndrome; attention defi cit hyperactivity disorder; iron defi ciency; ferritin; dopamine

show abstract

“…Long-term iron is not recommended; in addition, a family history of hemachromatosis would be considered a contraindication to therapy. Iron therapy has been shown to be effective for treating RLS and PLMs in children [111][112][113]. Both IV and oral iron administration have been reported.…”

Section: Restless Legs Syndrome (Rls)mentioning

confidence: 99%

Current Treatment of Selected Pediatric Sleep Disorders

Sullivan

2012

Neurotherapeutics

View full text Add to dashboard Cite

While pediatric sleep disorders are relatively common, treatments are often not straightforward. There is often a paucity of gold standard studies and data available to guide clinicians, treatments may yield arguably incomplete results, interventions may require chronic use, and/ or involve multiple modalities including behavioral interventions that require high parental and family commitment. This review points out diagnostic differences compared to adults and focuses on current therapy for selected common pediatric sleep disorders including sleep disordered breathing/ obstructive sleep apnea, narcolepsy, and restless legs syndrome. Other common pediatric sleep disorders, such as insomnia and parasomnias, are not covered.

show abstract

Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers

Cited by 104 publications

References 19 publications

Restless Legs Syndrome, Sleep, and Quality of Life among Adolescents and Young Adults

Restless Legs Syndrome, Sleep, and Quality of Life among Adolescents and Young Adults

Association between Low Serum Ferritin and Restless Legs Syndrome in Patients with Attention Deficit Hyperactivity Disorder

Current Treatment of Selected Pediatric Sleep Disorders

Contact Info

Product

Resources

About