Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Sriram, Roshan K.; Lo, Vivian; Pryce, Benjamin R.; Antonova, Lilia; Mears, Alan J.; Daneshmand, Manijeh; McKay, Bruce C.; Conway, Simon J.; Muller, William J.; Sabourin, Luc A.

doi:10.1186/s13058-014-0513-8

Cited by 15 publications

(14 citation statements)

References 75 publications

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“…Moreover, CK5 has been proposed by some authors to be a marker that determines basal-like features of breast cancer, along with ER, PR, HER2, and EGFR [ 86 ]. Several of the most important markers with prognostic and therapeutic values in breast cancer are summarized in Table 1 [ 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 ].…”

Section: Controversial Markers Of Normal Breast Tissue With Potentialmentioning

confidence: 99%

Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis

et al. 2016

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Normal human breast tissue consists of epithelial and nonepithelial cells with different molecular profiles and differentiation grades. This molecular heterogeneity is known to yield abnormal clones that may contribute to the development of breast carcinomas. Stem cells that are found in developing and mature breast tissue are either positive or negative for cytokeratin 19 depending on their subtype. These cells are able to generate carcinogenesis along with mature cells. However, scientific data remains controversial regarding the monoclonal or polyclonal origin of breast carcinomas. The majority of breast carcinomas originate from epithelial cells that normally express BRCA1. The consecutive loss of the BRCA1 gene leads to various abnormalities in epithelial cells. Normal breast epithelial cells also express hypoxia inducible factor (HIF) 1α and HIF-2α that are associated with a high metastatic rate and a poor prognosis for malignant lesions. The nuclear expression of estrogen receptor (ER) and progesterone receptor (PR) in normal human breast tissue is maintained in malignant tissue as well. Several controversies regarding the ability of ER and PR status to predict breast cancer outcome remain. Both ER and PR act as modulators of cell activity in normal human breast tissue. Ki-67 positivity is strongly correlated with tumor grade although its specific role in applied therapy requires further studies. Human epidermal growth factor receptor 2 (HER2) oncoprotein is less expressed in normal human breast specimens but is highly expressed in certain malignant lesions of the breast. Unlike HER2, epidermal growth factor receptor expression is similar in both normal and malignant tissues. Molecular heterogeneity is not only found in breast carcinomas but also in normal breast tissue. Therefore, the molecular mapping of normal human breast tissue might represent a key research area to fully elucidate the mechanisms of breast carcinogenesis.

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Section: Controversial Markers Of Normal Breast Tissue With Potentialmentioning

confidence: 99%

Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis

et al. 2016

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“…Furthermore, periostin interacts with various molecules to affect a number of pathways, such as Notch 1 signaling (9,10), and thus, a lack of periostin may be responsible for a suppression of Notch 1 signaling (9,10). Conversely, it cannot be excluded that the overexpression of periostin may result in the activation of Notch 1 signaling in cancer (10). Additionally, periostin was identified as being involved in gastric cancer cell epithelial-mesenchymal transition (EMT) (11).…”

Section: Introductionmentioning

confidence: 99%

Role of periostin in esophageal, gastric and colon cancer

et al. 2016

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Abstract. Periostin, also known as osteoblast-specific factor 2, is a cell-adhesion protein with pleiotropic properties. The protein serves a vital role in the maintenance and development of tooth and bone tissue, in addition to cardiac development and healing. Periostin levels are increased in several forms of cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, and esophageal head and neck carcinomas. The present review highlights the key role of periostin in tumorigenesis, particularly in increasing cell survival, invasion, angiogenesis, epithelial-mesenchymal transition and metastasis of carcinoma cells by interacting with numerous cell-surface receptors, including integrins, in the phosphoinositide 3-kinase-Akt pathway. In addition, periostin actively affects the canonical Wnt signaling pathway of colorectal tumorigenesis. The current review focused on the involvement of periostin in the development of colorectal, esophageal and gastric cancer.

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“…Periostin is a secreted matrix N‐glycoprotein that plays vital roles in numerous cancers, especially in gastrointestinal malignancy . For pancreatic cancer, it is reported that POSTN has a biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells, participates in the process of tumor angiogenesis, and could promote invasiveness and resistance of pancreatic cancer cells to induce cell death .…”

Section: Discussionmentioning

confidence: 99%

“…9,10 In the present study, we identified that POSTN and CA242 could be potential diagnostic Periostin is a secreted matrix N-glycoprotein that plays vital roles in numerous cancers, especially in gastrointestinal malignancy. 16,20,[22][23][24][25][26] For pancreatic cancer, it is reported that POSTN has a biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells, 17 participates in the process of tumor angiogenesis, 16 and could promote invasiveness and resistance of pancreatic cancer cells to induce cell death. 17,27 12 They reported a high correlation between the serum levels of CA242 and CA19.9, which is consistent with the results of our study.…”

Section: Discussionmentioning

confidence: 99%

Periostin and CA242 as potential diagnostic serum biomarkers complementing CA19.9 in detecting pancreatic cancer

Dong

Zhang

et al. 2018

Cancer Science

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Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with few biomarkers to guide treatment options. Carbohydrate antigen 19.9 (CA19.9), the most frequently used biomarker for PDAC, is not sensitive and specific enough for the detection of the disease. This study aimed to evaluate serum periostin (POSTN) and CA242 as potential diagnostic biomarkers complementing CA19.9 in detecting pancreatic cancer. Blood samples were from 362 participants, including 213 patients with different stages of PDAC, 75 patients with benign pancreatic disease, and 74 healthy individuals. All samples were randomly divided into a training set and a validation set. Carbohydrate antigen 19.9, CA242, POSTN, as well as carcinoembryonic antigen, were measured by ELISA or automated immunoassay. The receiver operating characteristic curve analysis revealed that the performance of CA19.9 in the validation group were improved by the marker panel composed of CA19.9, POSTN, and CA242, to discriminate early stage PDAC not only from healthy controls (area under the curve [AUC]CA19.9 = 0.94 vs AUCCA19.9 + POSTN + CA242 = 0.98, P < .05) but also from benign conditions (AUCCA19.9 = 0.87 vs AUCCA19.9 + POSTN + CA242 = 0.90, P < .05). In addition, POSTN retained significant diagnostic capabilities to distinguish PDAC CA19.9‐negative from healthy controls (AUCPOSTN = 0.87) as well as from benign conditions (AUCPOSTN = 0.84) in the whole set. This study suggested that POSTN and CA242 are potential diagnostic serum biomarkers complementing CA19.9 in detecting early pancreatic cancer.

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Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity

Cited by 15 publications

References 75 publications

Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis

Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis

Role of periostin in esophageal, gastric and colon cancer

Periostin and CA242 as potential diagnostic serum biomarkers complementing CA19.9 in detecting pancreatic cancer

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