Longitudinal study of neurological soft signs in first‐episode early‐onset psychosis

Mayoral, María; Bombín, Igor; Castro‐Fornieles, Josefina; González-Pinto, A.; Otero, Soraya; Parellada, Mara; Moreno, Dolores; Baeza, Inmaculada; Graell, Motserrat; Rapado, Marta; Arango, Celso

doi:10.1111/j.1469-7610.2011.02475.x

Cited by 40 publications

(25 citation statements)

References 39 publications

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“…The importance of prospective and longitudinal studies has been proposed because they provide novel insights into the pathophysiological processes of SCZ. In fact, several studies have examined the longitudinal developmental changes in potential endophenotypes or biomarkers mainly using neuroimaging techniques to capture pre-psychosis onset and the transition from the at-risk state to the illness or psychotic state [33], [34], [35], [36]. However, to accomplish these purposes, less costly and more easily implemented techniques are desirable if the methods are sensitive enough and can quantify performance sufficiently to detect onset and transition.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Persistency of Resting and Active Periods of Locomotor Activity in Schizophrenia

et al. 2012

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Patients with schizophrenia frequently exhibit behavioral abnormalities associated with its pathological symptoms. Therefore, a quantitative evaluation of behavioral dynamics could contribute to objective diagnoses of schizophrenia. However, such an approach has not been fully established because of the absence of quantitative biobehavioral measures. Recently, we studied the dynamical properties of locomotor activity, specifically how resting and active periods are interwoven in daily life. We discovered universal statistical laws (“behavioral organization”) and their alterations in patients with major depressive disorder. In this study, we evaluated behavioral organization of schizophrenic patients (n = 19) and healthy subjects (n = 11) using locomotor activity data, acquired by actigraphy, to investigate whether the laws could provide objective and quantitative measures for a possible diagnosis and assessment of symptoms. Specifically, we evaluated the cumulative distributions of resting and active periods, defined as the periods with physical activity counts successively below and above a predefined threshold, respectively. Here we report alterations in the laws governing resting and active periods; resting periods obeyed a power-law cumulative distribution with significantly lower parameter values (power-law scaling exponents), whereas active periods followed a stretched exponential distribution with significantly lower parameter values (stretching exponents), in patients. Our findings indicate enhanced persistency of both lower and higher locomotor activity periods in patients with schizophrenia, probably reflecting schizophrenic pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Enhanced Persistency of Resting and Active Periods of Locomotor Activity in Schizophrenia

et al. 2012

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“…A longitudinal study of 110 first-episode psychosis patients (53 with schizophrenia) younger than 18 years of age revealed more NSS in patients than controls at baseline and at the 2-year follow-up, suggesting them to be a trait marker of the investigated diseases [2]. Correlation analyses between subscales of the Neurological Evaluation Scale and clinical and pharmacological parameters were also performed, but only p values without correction for multiple comparisons were reported using a quite liberal statistical threshold.…”

Section: Correlation Of Nss With the Course Of Schizophreniamentioning

confidence: 99%

Neurology Issues in Schizophrenia

Hüfner

Frajo-Apor

Hofer

2015

Curr Psychiatry Rep

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Schizophrenia ranks among the leading causes of disability worldwide. The presence of neurological signs co-occurring with the psychiatric symptoms is indicative of an organic brain pathology. In the present article, we review the current literature on neurology issues in schizophrenia. Firstly, common neurological signs found in patients with schizophrenia (neurological soft signs and smell abnormalities) and their association with imaging findings are reviewed. Secondly, the significant association of schizophrenia with epilepsy and stroke is described as well as the absent association with other organic brain diseases such as multiple sclerosis. Thirdly, we discuss the potential role of NMDA receptor antibodies in schizophrenia. Fourthly, neurological side effects of antipsychotic drugs and their treatment are reviewed; and lastly, we discuss neurocognitive deficits in patients with schizophrenia and their treatment. The focus of the review remains on articles with relevance to the clinician.

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“…This is why it is present already during the early stages of a mental disorder (e.g. schizophrenia) and even during the prodromal phase (Peralta et al, 2011; Gunasekaran et al, 2016; Janssen et al, 2009; Mayoral et al, 2012; Thomann et al, 2009a,b; Fountoulakis et al, 2017b).…”

Section: Resultsmentioning

confidence: 99%

Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?

Fountoulakis

Panagiotidis

Kimiskidis

et al. 2018

Intl J of Devlp Neuroscience

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Longitudinal study of neurological soft signs in first‐episode early‐onset psychosis

Cited by 40 publications

References 39 publications

Enhanced Persistency of Resting and Active Periods of Locomotor Activity in Schizophrenia

Enhanced Persistency of Resting and Active Periods of Locomotor Activity in Schizophrenia

Neurology Issues in Schizophrenia

Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?

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