Longevity-promoting properties of ginger extract in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

Abstract

Ginger is a traditional medicinal and edible plant with multiple health-promoting properties.

In Vitro and In Vivo Insights into a Broccoli Byproduct as a Healthy Ingredient for the Management of Alzheimer’s Disease and Aging through Redox Biology

“…Lipofuscin acts as proteasome inhibitor by directly binding on proteasome complexes. Consequently, processes unrelated to ROS are also linked to lipofuscin accumulation, including autophagy. , Therefore, that kind of process may be altered in aged worms, which may not be modulated by BRO, explaining the noneffect observed in lipofuscin content. No data on broccoli or its byproducts have been found; however, other treatments, such as strawberry extract, partially prevented the accumulation of this pigment at the same concentration as BRO, probably mediated by anthocyanins …”

Ceramides from Sea Red Rice Bran Improve Health Indicators and Increase Stress Resistance of Caenorhabditis elegans through Insulin/IGF-1 Signaling (IIS) Pathway and JNK-1

“…In addition, the cellular antioxidant defense system requires the participation of antioxidant enzymes, such as SOD and CAT. 41 To test this contention, we evaluated enzyme activity indicators in nematodes fed Cers. We found that the relative expression of enzyme activities in C. elegans showed an increasing trend, implying that Cers accelerated the defense mechanisms of C. elegans, thereby preventing or delaying the denaturation of proteins when exposed to external stimuli such as heat stress.…”

“…elegans, thus enhancing their resistance to heat as well as extending their life span. In addition, the cellular antioxidant defense system requires the participation of antioxidant enzymes, such as SOD and CAT . To test this contention, we evaluated enzyme activity indicators in nematodes fed Cers.…”

Hypoglycemic effect of Lactobacillus plantarum-fermented mulberry pomace extract in vitro and in Caenorhabditis elegans

“…The transgenic strains TJ356 (containing DAF-16-fused GFP protein) and LD1 (containing SKN-1-fused GFP protein) were employed to detect the intracellular localization. 29 The synchronized L4-stage worms were cultured with model/NF/F9 (2% glucose) or control (without glucose) for 48 h, then the worms were anesthetized with 2% sodium azide and photographed using fluorescence microscopy (Nikon Eclipse 90i) to monitor the nuclear translocation of DAF-16::GFP and SKN-1:: GFP. The nuclear translocation patterns were identified as 'cytosolic', 'intermediate', and 'nuclear'.…”