Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

Liu, Jie; Chen, Chao; Ji, Shenglu; Liu, Qian; Ding, Dan; Zhao, Dan

doi:10.1039/c6sc04384d

Cited by 167 publications

(138 citation statements)

References 55 publications

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“…PDTPBD, PDTPBT, and PDTPBSe NPs showed 74%, 50%, and 43% higher PA intensity than those obtained before NP injection, indicating the strong PA generation ability of the NPs. Then, the PA signals decreased to the value equal to the background because of the accumulation of CPNs in liver and spleen tissues through the reticuloendothelial system uptake . The results obtained at 800 nm exhibited similar trends as that obtained at 700 nm (Figure b).…”

Section: Resultssupporting

confidence: 71%

Molecular Engineering of Photoacoustic Performance by Chalcogenide Variation in Conjugated Polymer Nanoparticles for Brain Vascular Imaging

Cai

Pan

Bandla

et al. 2018

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As conjugated polymer nanoparticles (CPNs) have attracted growing interest as photoacoustic (PA) imaging contrast agents, revelation of the relationship between the molecular structure of conjugated polymers and PA property is highly in demand. Here, three donor-acceptor-structured conjugated polymer analogs are designed, where only a single heteroatom of acceptor units changes from oxygen to sulfur to selenium, allowing for systematic investigation of the molecular structure-PA property relationship. The absorption and PA spectra of these CPNs can be facilely tuned by changing the heteroatoms of the acceptor units. Moreover, the absorption coefficient, and in turn the PA signal intensity, decreases when the heteroatom changes from oxygen to sulfur to selenium. As these CPNs exhibit weak fluorescence and similar photothermal conversion efficiency (≈70%), their PA intensities are approximately proportional to their absorption coefficients. The in vivo brain vasculature imaging in this study also demonstrates this trend. This study provides a simple but efficient strategy to manipulate the PA properties of CPNs through changing the heteroatom at key positions.

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Section: Resultssupporting

confidence: 71%

Molecular Engineering of Photoacoustic Performance by Chalcogenide Variation in Conjugated Polymer Nanoparticles for Brain Vascular Imaging

Cai

Pan

Bandla

et al. 2018

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“…It is well accepted that near‐infrared imaging is advantageous for image‐guided tumor resection in light of its deep light penetration, negligible autofluorescence in the near‐infrared region and real‐time visualization capabilities. Liu et al designed 8 (Figure ), which shows AIE characteristics and exhibits emission maxima in the near‐infrared range. It is well known that bioluminescence from luciferase following injection of the substrate d ‐luciferin can precisely report the in vivo distribution of tumor nodules .…”

Section: Applications Of Aie Probes In the Field Of Biological Sciencementioning

confidence: 99%

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

Guo

Song

et al. 2019

Medicinal Research Reviews

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Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.

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“…To achieve this goal, two series of donoracceptor-donor (D-A-D) structured compounds: ɑ-DTPEBBTD-C x and β-DTPEBBTD-C x were designed and synthesized ( Fig.3) [50]. The monoalkoxy-substituted TPE as an electron donor formed the D-A-D structures with BBTD as an electron acceptor to produce the NIr emissive AIE molecules with desirable absorption and emission maxima for in vivo imaging applications.…”

Section: Photosensitizersmentioning

confidence: 99%

Nanoparticles-based photosensitizers with effect of aggregation-induced emission

Korneev¹,

Сахно

Короткова

2019

Biopolym. Cell

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Photodynamic therapy (PDT) is a method of the treatment of localized cancers, based on a photochemical reaction between a light-activated molecule or photosensitizer (PS), light, and molecular oxygen. Correct choice of PS is of fundamental importance for PDT efficacy. Despite numerous studies in this field, most known PS have some drawbacks, e.g. lack of specificity and aggregation in aqueous media. Consequently, the search for an ideal PS is essential for further development of PDT. Here we review classification and analyse main features of different generations of PS and describe the mechanisms of their action. Various methods of targeted delivery of PS to tumor cells are discussed. The advantages of PS nanoparticles with the effect of aggregation-induced emission (AIE) over the classic photosensitizers are presented. A possibility of practical application of such light-emitting structures in cancer phototherapy is shown. K e y w o r d s: photodynamic therapy (PDT), photosensitizer, aggregation-induced emission ABBrEVIATIONS AEMA -2-aminoethyl methacrylate ALA -5-aminolevulinic acid AlPc -aluminum-phthalocyanine chloride AlPcS4 -aluminium-phthalocyanine tetrasulphonated (Photosens) AlS2Pc -disulfonated phthalocyanine BDP -borondipyrromethene BHQ3 -black hole quencher3 BSA -bovine serum albumin c(rGDfc) -Arg-Gly-Asp-d-Phe-Cys cyclicpeptide crGD -cyclic arginine-glycine-aspartic acid DCF-DA -dichlorofluoresceindiacetate DMSO -Dimethylsulfoxide DPBA-TPE -(3,3'-(2,5-dimethoxy-1,4-phenylene)bis(2-(4bromophenyl)acrylonitrile)-tetraphenylethene DSPE-PEG-Mal -1,2-distearoyl-sn-glycero3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] DTPEBBTD -Donor-tetraphenylethene-benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole) Fr/NIr -far-red/ near-infrared GFLG -Gly-Phe-Leu-Gly-peptide HPMA -N-(2-hydroxypropyl)methacrylamide m-THPP -meta-tetra(hydroxyphenyl)porphyrin (Foscan)

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Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

Abstract: Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

Cited by 167 publications

References 55 publications

Molecular Engineering of Photoacoustic Performance by Chalcogenide Variation in Conjugated Polymer Nanoparticles for Brain Vascular Imaging

Molecular Engineering of Photoacoustic Performance by Chalcogenide Variation in Conjugated Polymer Nanoparticles for Brain Vascular Imaging

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

Nanoparticles-based photosensitizers with effect of aggregation-induced emission

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