Nanoparticles-based photosensitizers with effect of aggregation-induced emission

Korneev, O.V.; Сахно, Т. В.; Короткова, І. В.

doi:10.7124/bc.000a08

Cited by 5 publications

(3 citation statements)

References 61 publications

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“…Benefitting from the unparalleled fluorescence properties and the consequent excellent performances in fluorescence imaging (FLI)-guided PDT, the emergence of PSs with aggregation-induced emission (AIE) property made the development of organic PSs enter upon a new phase by enabling the concomitant diagnostic FLI. [34][35][36] To be specific, AIE refers to a unique phenomenon that some conformation-twisted fluorophores emit immensely enhanced fluorescence in aggregate state than that of their dissolved molecule state owing to the mechanism of restriction of motion (RIM) (Figure 1a). [28,[37][38][39] After aggregating, the excited energy of AIE luminogens (AIEgens), which originally consumed by the active intramolecular motions in solution, is switched to undergo radiative consumption pathway because the intramolecular motions-involved nonradiative thermal deactivation is largely restrained, thus elucidating the aggregation-intensified emission (Figure 1b).…”

Section: Introductionmentioning

confidence: 99%

Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics

Liu

Kang

et al. 2023

Small Structures

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Threats posed by recalcitrant bacterial biofilms have been continuously challenging the public health due to the dramatically magnified antibiotic resistance resulted from the complicated biofilm microenvironment. Urgent demands on effective biofilm combating have propelled the rapid exploration of high‐performance antibiofilm systems. Thanks to the distinguished features of aggregation‐intensified fluorescence and aggregation‐enhanced generation of reactive oxygen species, aggregation‐induced emission luminogens (AIEgens) are becoming increasingly eye‐catching in the field of biofilm combating by serving as excellent fluorescence imaging probes or theranostic agents. This review aims to, for the first time, outline the current progress of AIEgens in bacterial biofilm imaging and antibiofilm theranostics. The up‐to‐date advancements of AIEgens in enzyme‐responsive biofilm imaging, discriminative imaging of Gram‐positive bacterial biofilm, as well as biofilm viability monitoring are summarized at first. Subsequently, the antiadhesion intervention‐mediated prevention of biofilm formation and photodynamic therapy‐involved eradication of preexisting biofilms are detailedly elucidated. Finally, a brief conclusion as well as a discussion on the current challenges and future expectations is presented.

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Section: Introductionmentioning

confidence: 99%

Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics

Liu

Kang

et al. 2023

Small Structures

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“…These nanoparticles have an increased surface area for drug delivery and they are responsive to near infrared wavelengths, just as AIE-photosensitizers. Currently, many of these AIE-photosensitizer nanoparticles have absorption maxima below 500 nm and emission spectra below 700 nm, although, it is desirable to have absorption spectra with a narrow band gap and emission maxima around 800 nm for the best biological effects ( Korneev et al, 2019 ). These AIE-photosensitizers are quite useful for cancer therapy and can overcome resistance to antibiotics in microbes.…”

Section: Introductionmentioning

confidence: 99%

Structure and functions of Aggregation-Induced Emission-Photosensitizers in anticancer and antimicrobial theranostics

2022

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Photosensitizers with Aggregation-Induced Emission (AIE) can allow the efficient light-mediated generation of Reactive Oxygen Species (ROS) based on their complex molecular structure, while interacting with living cells. They achieve better tissue targeting and allow penetration of different wavelengths of Ultraviolet-Visible-Infrared irradiation. Not surprisingly, they are useful for fluorescence image-guided Photodynamic Therapy (PDT) against cancers of diverse origin. AIE-photosensitizers can also function as broad spectrum antimicrobials, capable of destroying the outer wall of microbes such as bacteria or fungi without the issues of drug resistance, and can also bind to viruses and deactivate them. Often, they exhibit poor solubility and cellular toxicity, which compromise their theranostic efficacy. This could be circumvented by using suitable nanomaterials for improved biological compatibility and cellular targeting. Such dual-function AIE-photosensitizers nanoparticles show unparalleled precision for image-guided detection of tumors as well as generation of ROS for targeted PDT in living systems, even while using low power visible light. In short, the development of AIE-photosensitizer nanoparticles could be a better solution for light-mediated destruction of unwanted eukaryotic cells and selective elimination of prokaryotic pathogens, although, there is a dearth of pre-clinical and clinical data in the literature.

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“…Second, different approaches for tumor-targeting AIEgen-based PSs were covered. This review does not aim to be comprehensive; readers are also encouraged to refer to other excellent reviews for more information [ 32 , 33 , 34 , 35 , 36 , 37 ]. Due to the fast advances in this field, we only summarized some representative works during the past three years.…”

Section: Introductionmentioning

confidence: 99%

Aggregation-Induced Emission Luminogens for Enhanced Photodynamic Therapy: From Organelle Targeting to Tumor Targeting

Zhou

Chen

et al. 2022

Biosensors

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Photodynamic therapy (PDT) has attracted much attention in the field of anticancer treatment. However, PDT has to face challenges, such as aggregation caused by quenching of reactive oxygen species (ROS), and short 1O2 lifetime, which lead to unsatisfactory therapeutic effect. Aggregation-induced emission luminogen (AIEgens)-based photosensitizers (PSs) showed enhanced ROS generation upon aggregation, which showed great potential for hypoxic tumor treatment with enhanced PDT effect. In this review, we summarized the design strategies and applications of AIEgen-based PSs with improved PDT efficacy since 2019. Firstly, we introduce the research background and some basic knowledge in the related field. Secondly, the recent approaches of AIEgen-based PSs for enhanced PDT are summarized in two categories: (1) organelle-targeting PSs that could cause direct damage to organelles to enhance PDT effects, and (2) PSs with tumor-targeting abilities to selectively suppress tumor growth and reduce side effects. Finally, current challenges and future opportunities are discussed. We hope this review can offer new insights and inspirations for the development of AIEgen-based PSs for better PDT effect.

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Nanoparticles-based photosensitizers with effect of aggregation-induced emission

Cited by 5 publications

References 61 publications

Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics

Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics

Structure and functions of Aggregation-Induced Emission-Photosensitizers in anticancer and antimicrobial theranostics

Aggregation-Induced Emission Luminogens for Enhanced Photodynamic Therapy: From Organelle Targeting to Tumor Targeting

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