Long-Term Survival of Patients with Gastrointestinal Haemorrhage with Special Reference to the ABO Blood Groups

Abstract

Among 986 patients admitted to hospital in the period 1938 to 1967 for gastrointestinal haemorrhage, 882 were blood grouped. A significant excess of blood group 0 was found among patients with haemorrhagic gastritis and duodenal ulcer. Of 802 blood-grouped patients who left the hospital alive, 800 were retraced 2 to 31 years later. The observed deaths exceeded the expected in all groups, being most pronounced in patients previously operated on, followed by patients with gastric ulcer. duodenal ulcer, and haemorrhagic gastritis. The reason for the higher number of deaths than expected was primarily a continuing high death rate due to haemorrhage, perforation. and selective operation for ulcer. Patients with blood group 0, B or AB had a higher excess death rate than patients with blood group A. The difference however was not statistically significant. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. 4. Berg, M. 1969. lnfluence of age and ABO blood group in the precipitation of bleeding peptic ulcers. Gtrt 10, 1029-1030. 90, 65-84. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14 For personal use only. Review of medically treated bleeding gastric or duodenal ulcers. Actn chir. scand. 120, 66-78. 42, 292-294. Scand J Gastroenterol Downloaded from informahealthcare.com by Nyu Medical Center on 11/02/14For personal use only.

Relationship between ABO Blood Group and Hemorrhage: A Systematic Literature Review and Meta-Analysis

“…Furthermore, as assessment of methodologic quality, we decided to consider higher quality studies in which investigators did not use population data as controls. [13][14][15][16][17][18][19][20][21][22][23]…”

“…We finally planned a priori subgroup analyses, including only patients with mucosal (gastrointestinal and mucocutaneous) hemorrhages. [13][14][15][16][17][22][23][24][25][26][27][28][29][30] Data Synthesis and Data Analyses…”

“…Therefore, 22 studies were finally included in our systematic review. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][33][34][35][36]…”

“…Baseline characteristics of included studies are summarized in ►Table 2. All included studies provided data on the prevalence of blood groups in patients with bleeding events and in controls: cases included patients with upper gastrointestinal bleeding (12 studies [13][14][15][16][17]24,[26][27][28]30,33,34,36 ), patients with cerebral hemorrhage (2 studies 34,35 ), patients with intra-or postpartum hemorrhage (1 study 20 ), patients with mucouscutaneous hemorrhage (2 studies 23,29 ), patients with epistaxis (1 study 22 ), patients with menorrhagia (1 study 25 ), patients with bleeding during anticoagulant treatment (2 studies 18,19 ), and patients with general bleeding problems (1 study 21 ). For 9 studies, a subgroup of patients included in the original study was selected for the aim of our systematic review.…”

Relative Risks of Thrombosis and Bleeding in Different ABO Blood Groups

“…Nearly 50 years ago, Horwich et al 50 found a significantly higher frequency of group O in subjects with bleeding duodenal ulcers over the normal controls, and these results were replicated by subsequent studies. [51][52][53] Reddy et al 54…”