Relative Risks of Thrombosis and Bleeding in Different ABO Blood Groups

Franchini, Massimo; Lippi, Giuseppe

doi:10.1055/s-0035-1564832

Cited by 31 publications

(15 citation statements)

References 48 publications

(40 reference statements)

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“…The association of these SNPs with thrombosis and with the PFA-100 phenotypes suggests that this functional platelet test may be useful to estimate thrombotic risk, although further studies are needed to confirm this. Moreover, some of the SNPs have been described also in association with variations in VWF, FVIII, and/or variations in biological factors that may play indirect roles in thrombosis, such as adhesion molecules [17,18,37,38,39].…”

Section: Resultsmentioning

confidence: 99%

Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes

Pujol-Moix

Martinez-Perez

Sabater‐Lleal

et al. 2019

IJMS

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(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: closure time of collagen-ADP (Col-ADP) and of collagen-epinephrine (Col-Epi). (2) Methods: As part of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia (2) Project, 935 individuals from 35 large Spanish families were studied. A genome-wide association study (GWAS) with ≈ 10 M single nucleotide polymorphisms (SNPs) was carried out with Col-ADP and Col-Epi phenotypes. (3) Results: The study yielded significant genetic signals that mapped to the ABO locus. After adjusting both phenotypes for the ABO genotype, these signals disappeared. After adjusting for von Willebrand factor (VWF) or for coagulation factor VIII (FVIII), the significant signals disappeared totally for Col-Epi phenotype but only partially for Col-ADP phenotype. (4) Conclusion: Our results suggest that the ABO locus exerts the main genetic influence on PFA-100 phenotypes. However, while the effect of the ABO locus on Col-Epi phenotype is mediated through VWF and/or FVIII, the effect of the ABO locus on Col-ADP phenotype is partly produced through VWF and/or FVIII, and partly through other mechanisms.

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Section: Resultsmentioning

confidence: 99%

Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes

Pujol-Moix

Martinez-Perez

Sabater‐Lleal

et al. 2019

IJMS

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“…Researchers have recently determined that, the genetic "host" factors might play a role in the development of GI bleeding [16][17][18]. Among these factors, O blood type as a genetic predisposing factor has been shown to influence susceptibility to Helicobacter pylori infection, duodenal ulcer and possible bleeding tendency [11] hence facilitating the development of GI bleeding [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, this thrombotic event was happened through the modulation of Von-Will brand Factor and Factor VIII plasma levels, which are the main risk factors for venous thrombosis. Additionally, platelet function is also compromised in O blood group [10,11]. Since the distribution of ABO blood type genes varies among different racial and ethnic groups, we designed this study to assess the role of ABO blood group system in development of GI bleeding and its short term clinical outcome in Iranian population.…”

Section: Introductionmentioning

confidence: 99%

Association between ABO Blood Group and Clinical Outcomes in Patients with Gastrointestinal Bleeding

Bahardoust¹,

Naghshin²,

Mokhtare³

et al. 2018

Intern Med

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Introduction: Gastrointestinal (GI) bleeding is one of the most common causes of Emergency Room (ER) visits all around the world. Previous studies proved the relationship between ABO blood group and the bleeding diathesis. Distribution of ABO blood type antigens is various among the different races. This study aimed to assess the role of ABO blood group system in the development of GI bleeding in Iranian population. Method and Material: Patients with acute upper and/or lower non-traumatic GI bleeding who admitted in ER of Rasoul-e-Akram hospital and the healthy blood donor between 2014 and 2016, were enrolled in this prospective case-control study. Demographic criteria, clinical presentation, laboratory data, endoscopic findings and GI bleeding outcome during the first 72 hours of admission were recorded. All variables were analyzed by SPSS software version 22. Results: Overall, 513 case and 520 control groups completed the study. The risk of bleeding originated from esophageal, gastric and duodenal ulcers were significantly higher among patients with O blood group (P value=0.032, 0.021 and 0.009, respectively). Need for blood transfusion was significantly higher among patients with O blood group (P value=0.032). Older males had higher risk of developing GI bleeding (P value is 0.001and 0.003, respectively) in this study. Conclusion: O blood type is significantly more common in Iranian patients with GI bleeding in comparison to the healthy blood donors. It seems that it is a prognostic genetic and individual risk factor for bleeding tendency in these patients, especially in those with upper GI bleeding.

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“…Although there are studies on physiological functions of blood groups, this topic remains a mystery. Previous studies demonstrated associations between ABO blood groups and diabetes (15), obesity (16), cancer (17) and venous thrombosis (18). Previous studies showed that obesity is affected by ABO blood groups; however, the mechanism could not be clarified completely.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Physical Activity in Obese and Non-Obese Women and Investigation of the Relationship between Physical Activity with ABO Blood Groups and Rh factor

Çeçen¹,

Eren²

2020

JSTR

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Introduction:Decreased physical activity is an important risk factor for obesity. The International Physical Activity Questionnaire (IPAQ) has been developed to determine physical activity levels. Previous studies showed that obesity is affected by ABO blood types. Aim of the study was to search whether blood groups are associated with the level of physical activity. If proven, this will indicate that the blood groups may be one of the genetic factors that influence inclination towards obesity. Material and Methods:The study included 306 (n=211 obese, n=95 nonobese) female between the ages of 18 and 65 years. Body weights, BMI (body mass index) fat percentage, fat mass and fat-free mass were determined by using bio-impedance device. The short (IPAQ-S) and long form of (IPAQ-L) questionnaire was implemented through personal interview. ABO and Rh blood groups were determined via Microplack method.Results: No significant difference for IPAQ-S (vigorous, moderate, walking, sitting time, total physical activity) between obese and nonobese groups. However, the activity level of nonobese group was detected higher than obese group. According to IPAQ-L only significant difference in house yard-work detected higher in the obese group. There was no significant result obtained in evaluation of IPAQ-S and IPAQ-L by ABO blood groups in obese and nonobese group. There was no significant outcome detected in Rh factor and IPAQ-S in obese and nonobese group; however, a significant outcome was detected in IPAQ-L. Conclusion:Lack of significant findings in obese and nonobese groups in terms of physical activity levels according to IPAQ-S and IPAQ-L in the study reminds that obesity cannot be explained by physical activity alone. We could not detect a significant association between ABO blood groups and physical activity. Furthermore, the present study indicated that explaining obesity and physical activity in association with a single factor is difficult. ÖzetAmaç: Fiziksel aktivite azalmasının obezitede önemli bir risk faktörü olduğu bilinmektedir. Uluslararası Fiziksel Aktivite Anketi (IPAQ) fiziksel aktivite düzeylerini belirlemek amacıyla geliştirilmiştir. Obezitenin kan gruplarından etkilendiği daha önceden yapılan çalışmalarda gösterilmiş olup, bu çalışmamızda amacımız kan gruplarının fiziksel aktiviteyi etkileyip etkilemediğini araştırmaktır. Kanıtlanırsa eğer, kan gruplarının obeziteye eğilimi etkileyen genetik faktörlerden biri olabileceğini düşünmek mümkün olabilir. Gereç ve Yöntemler:Çalışmaya 18-65 yaş arası 306 kadın (0bez =211, obez olmayan=95) katıldı.Boy uzunlukları ölçüldükten sonra biioimpedans cihazında kilo, beden kitle indeksi, yağ yüzdesi, yağ ağırlığı, yağsız ağırlık tesbit edildi. Uluslararası Fiziksel Aktivite Anketi kısa ve uzun form yüzyüze görüşmeyle birebir uygulandı.kan grubu tayini Kan Bankasında Microplack metodu ile saptandı.Bulgular: Uluslararası Fiziksel Aktivite Anketi kısa formda (şiddetli, orta dereceli fizik aktivite, yürüme, oturma süresi, total fiziksel aktivite) obez ve obez olmayan grupta a...

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Relative Risks of Thrombosis and Bleeding in Different ABO Blood Groups

Cited by 31 publications

References 48 publications

Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes

Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Results of a GWAS on GAIT-2 Project Phenotypes

Association between ABO Blood Group and Clinical Outcomes in Patients with Gastrointestinal Bleeding

Comparison of Physical Activity in Obese and Non-Obese Women and Investigation of the Relationship between Physical Activity with ABO Blood Groups and Rh factor

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