Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls ( p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity ( r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.

Complete and early resection of bronchiectasis provides a successful outcome. Duration of symptoms and timely intervention have a major impact on the management and prognosis.

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Amaç: Bölgemizdeki kan grubu dağılımını bilmek ve gereksinim halinde bunu pratik ve bilimsel anlamda kullanmayı amaçladık.Yöntemler: 2012-2018 yılları arasında, Kan merkezine kan bağışı amacı ile başvuran 123,900 sağlıklı bireyin kan grupları retrospektif olarak analiz edildi. Kan merkezimize başvuran kişilerin ABO ve Rh kan grupları mikroplak aglütinasyon veya kolon aglütinasyon yöntemleri ile tespit edilmiştir.

Six hydatid cysts cases without a primary source anywhere were presented. Hydatid cyst is a parasitic disease well known for years are commonly located in liver and lungs. Those intradiaphragmatic and intramyocardiac were diagnosed preoperatively but those lying subcutaneously on sternum and the right first rib were recognized after operation. They were also confirmed with pathologic study. Patients were also detected for hydatid cysts elsewhere. As an endemic disease in our country, atypical locations should be kept in mind. This disease is to be remembered in considering soft tissue tumors. J Clin Exp Invest 2013; 4 (3): 352-355