2013
DOI: 10.1007/s11239-013-1027-4
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Hemostasis, cancer, and ABO blood group: the most recent evidence of association

Abstract: Human ABO blood group antigens are expressed on the surface of red blood cells and a variety of human cells and tissues. However, an increasingly number of studies show that the ABO blood group, in addition to its fundamental role in transfusion medicine and in several other disciplines, has a causal role in predisposing to several human diseases, including hemostasis and neoplastic disorders, which will be the focus of this narrative review.

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Cited by 59 publications
(74 citation statements)
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“…Further studies confirmed the protective effect of O group and showed that the A1 allele (which is responsible for an increased glycosyltransferase activity) confers a greater risk of pancreatic cancer than the A2 allele [38]. As regards gastric cancer, the higher prevalence of blood group A in patients with carcinoma of the stomach historically observed by several studies [36] has been recently confirmed in a large prospective population-based study involving more than one million of Scandinavian blood donors, who were followed for up to 35 years (OR 1.20; 95% CI: 1.02-1.42) [39]. A similar finding emerged also in the recently published Golestan Cohort Study, which analyzed the association between the ABO blood groups, overall and cause-specific mortality in over 50,000 people recruited between the 2004 and 2008 [40].…”
Section: Abo and Cancerssupporting
confidence: 52%
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“…Further studies confirmed the protective effect of O group and showed that the A1 allele (which is responsible for an increased glycosyltransferase activity) confers a greater risk of pancreatic cancer than the A2 allele [38]. As regards gastric cancer, the higher prevalence of blood group A in patients with carcinoma of the stomach historically observed by several studies [36] has been recently confirmed in a large prospective population-based study involving more than one million of Scandinavian blood donors, who were followed for up to 35 years (OR 1.20; 95% CI: 1.02-1.42) [39]. A similar finding emerged also in the recently published Golestan Cohort Study, which analyzed the association between the ABO blood groups, overall and cause-specific mortality in over 50,000 people recruited between the 2004 and 2008 [40].…”
Section: Abo and Cancerssupporting
confidence: 52%
“…Another area that has been extensively studied over the last five decades is that of the association between the ABO blood group types and cancer, with and the most consistent relationship being observed for pancreatic and gastric cancers [36]. In the Nurses' Health Study and Health Professionals Follow-up Study, Wolpin and colleagues [37] found that participants with blood groups A, AB or B were more likely to develop pancreatic cancer compared to those with blood group O (adjusted hazard ratio [aHR] 1.44; 95% CI: 1.14-1.82).…”
Section: Abo and Cancersmentioning
confidence: 99%
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“…11 The higher prevalence of blood group A in patients with gastric cancer formerly observed by several studies has also been recently confirmed in a large prospective population-based study involving more than one million of Scandinavian blood donors followed for up to 35 years. 12,13 The association between ABO blood types and colon cancer showed an increased risk of colon carcinoma in AB blood type. 14 Rachna Bhattarai, International Chef and dietician, in an interview in Guardian News Bureau, stated that people having B+ blood group should refrain from eating grain based food as it can affect their bones.…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, several studies have suggested that importance of ABO blood group system in the development of hemostasis and neoplastic disease, because of ABO antigens are highly expressed on the surface of a variety of human cells and tissues [18]. However, to date, association between ABO blood type and lung cancer survival have not been well developed.…”
Section: Discussionmentioning
confidence: 99%