Long-term risk of developing epilepsy after febrile seizures

Neligan, Aidan; Bell, Gail S.; Giavasi, Christina; Johnson, Anthony L.; Goodridge, D; Shorvon, Simon; Sander, Josemir W.

doi:10.1212/wnl.0b013e31824f807a

Cited by 53 publications

(37 citation statements)

References 17 publications

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“…For example, after a febrile convulsion, the risk of developing epilepsy is 6%, reducing over time. 68 imaging or electroencephalographic abnormalities (spikes, slow waves, or both) are the strongest predictors of recurrence across many studies. 70 For patients with one or both of these factors, the risk of recurrence is 70% over five years.…”

Section: Is This a First Seizure And Will It Recur?mentioning

confidence: 99%

First seizures in adults

Angus‐Leppan

2014

BMJ

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Section: Is This a First Seizure And Will It Recur?mentioning

confidence: 99%

First seizures in adults

Angus‐Leppan

2014

BMJ

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“…In addition, studies with the general population have established history of febrile seizures as a factor leading to development of non-febrile seizures later in life [18, 19]. Lastly, a study by Wang et al (2011) found higher prevalence of GI dysfunctions in children with ASD compared to their ASD unaffected siblings, indicating the importance of controlling for GI status when assessing relative prevalence of seizures in ASD [6].…”

Section: Resultsmentioning

confidence: 99%

“…Yet such distinction is critical since the pathophysiology and risk factors associated with febrile seizures differ from other types of seizures, and febrile seizures are known to increase the risk of developing non-febrile seizures later in life [18–20]. Also, when assessing seizure prevalence, it is important to distinguish whether the ASD diagnosis is primary (idiopathic) or secondary to another neurological disorder (e.g.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study

et al. 2016

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BackgroundAutism spectrum disorder (ASD) is a heterogeneous disorder characterized not only by deficits in communication and social interactions but also a high rate of co-occurring disorders, including metabolic abnormalities, gastrointestinal and sleep disorders, and seizures. Seizures, when present, interfere with cognitive development and are associated with a higher mortality rate in the ASD population.MethodsTo determine the relative prevalence of non-febrile seizures in children with idiopathic ASD from multiplex and simplex families compared with the unaffected siblings in a cohort of 610 children with idiopathic ASD and their 160 unaffected siblings, participating in the Autism Genetic Resource Exchange project, the secondary analysis was performed comparing the life-time prevalence of non-febrile seizures. Statistical models to account for non-independence of observations, inherent with the data from multiplex families, were used in assessing potential confounding effects of age, gender, and history of febrile seizures on odds of having non-febrile seizures.ResultsThe life-time prevalence of non-febrile seizures was 8.2% among children with ASD and 2.5% among their unaffected siblings. In a logistic regression analysis that adjusted for familial clustering, children with ASD had 5.27 (95%CI: 1.51–18.35) times higher odds of having non-febrile seizures compared to their unaffected siblings. In this comparison, age, presence of gastrointestinal dysfunction, and history of febrile seizures were significantly associated with the prevalence of non-febrile seizures.ConclusionChildren with idiopathic ASD are significantly more likely to have non-febrile seizures than their unaffected siblings, suggesting that non-febrile seizures may be ASD-specific. Further studies are needed to determine modifiable risk factors for non-febrile seizures in ASD.

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“…The risk of recurrent FS after a first seizure is about 30-40%, but the risk of subsequent epilepsy is only slightly increased since simple FS are followed by epilepsy in less than 2% of patients, which is similar to the risk in the general population [3,4]. However, a higher proportion of patients develop epilepsy following complex FS, with the reported incidence ranging from 4.1% to 7% [4,5].…”

Section: Introductionmentioning

confidence: 80%