Predictive value of paroxysmal EEG abnormalities for future epilepsy in focal febrile seizures

Gradišnik, Peter; Zagradišnik, Boris; Palfy, Miroslav; Kokalj-Vokac, Nadja; Marcun-Varda, Natasa

doi:10.1016/j.braindev.2015.02.005

Cited by 13 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 The number of febrile seizures has been suggested as one of the risk factors for associated epileptiform activity by some authors. 12 In our study, the highest positive predictive value of epileptiform discharges was indeed calculated in the group with recurrent febrile seizures (38.5%).…”

Section: Discussionsupporting

confidence: 55%

“…Among 9 patients with epileptiform changes in the EEG and subsequent epileptic seizures, 6 had epileptiform discharges over the frontal regions. Frontal localization has been described as a positive predictor for subsequent epilepsy by other authors [10][11][12] in patients with febrile seizures. Many studies also reported that EEG may gain its predictability for subsequent epilepsy in children with abnormal neurologic or developmental status before febrile seizure, 13,[22][23][24] which was observed in our study as well.…”

Section: Discussionmentioning

confidence: 87%

“…9 The use of EEG in patients with complex and recurrent febrile seizures has been extensively studied in the past, but the conclusions differ. Several studies [10][11][12] have shown that epileptiform discharges on the EEG can be a positive predictive marker for subsequent epilepsy. According to some authors, 13,14 EEG should be obtained in every patient after a complex febrile seizure.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Predictive Value of Epileptiform Discharges for Subsequent Epilepsy After Febrile Seizures

Kavčič

Rener-Primec

2018

J Child Neurol

View full text Add to dashboard Cite

The predictive value of epileptiform discharges for subsequent epilepsy after febrile seizures was studied in 140 children: 72 children (51%) had simple febrile seizures and 68 children (49%) had complex febrile seizures. Electroencephalography (EEG) was performed in 103 children (74%), it was normal in 66 (47%) and with epileptiform patterns in 37 patients (26%). At follow-up in 2017, 10 children developed epilepsy, 1 had a single epileptic seizure, 9 of them had epileptiform EEGs. Of the patients with normal EEGs after complex febrile seizures, none developed epilepsy, and 92% of patients with normal EEGs after recurrent febrile seizures did not develop epilepsy. Therefore, patients with normal EEGs were unlikely to develop epilepsy. Fifteen percent of patients with complex and 31% of patients with recurrent febrile seizures and epileptiform EEGs developed epileptic seizures. The positive predictive value of epileptiform discharges was low in complex and twice as high in recurrent febrile seizures.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

See 1 more Smart Citation

Predictive Value of Epileptiform Discharges for Subsequent Epilepsy After Febrile Seizures

Kavčič

Rener-Primec

2018

J Child Neurol

View full text Add to dashboard Cite

show abstract

“…[28][29][30] In our study, among 10 patients with SES, 5 had epileptiform discharges over the frontopolar regions. Frontal localization has been described as a positive predictor for subsequent epilepsy by other authors 28,[31][32][33] in patients with FS.…”

Section: Discussionmentioning

confidence: 84%

Clinical Predictive Factors of Pathological EEG in Children with Febrile Seizures and Their Association with Subsequent Epileptic Seizures

Kchaou

Kammoun

Chakroun

et al. 2021

Journal of Pediatric Epilepsy

View full text Add to dashboard Cite

The objective of this study was to identify clinical parameters predicting either a pathological EEG or a subsequent epileptic seizure (SES), based on the relation between paroxysmal EEG abnormalities and clinical features in children who presented at least one febrile seizure (FS). We collected data of children who presented to our department during the period 2013 to 2018 for EEG recording as part of their febrile seizure assessment. Only children aged between 1 month to 5 years were included. Both the clinical and EEG data were retrospectively collected and statistically studied. We performed a detailed analysis of the EEG recordings. SES was identified for patients with sufficient follow-up. A total of 120 children were included in the study, of whom 48% had EEG abnormalities. Psychomotor retardation (p = 0.002), completion of an EEG within 7 days of the last FS (p = 0.046), and late age (> 3 years) of the first FS onset (p = 0.021) were significantly associated with a pathological EEG. In multivariate analysis, performing early EEG (< 7 days from the last FS) (odds ratio [OR]: 2.35; p = 0.043; confidence interval [CI]: 1.028–5.375) and psychomotor retardation (OR: 4.19; p = 0.008; CI: 1.46–12) were independent predictors of a pathological EEG. Of 120 patients, 45 had a follow-up. However, only 10 (22.22%) had SES. Children with SES tended more to have a psychomotor delay, compared with children without SES (50% vs. 14.28%, p = 0.029). Moreover, the percentage of initial abnormal EEG in patients with SES was significantly higher than those without SES (70% vs. 34.28%, p = 0.05). Even though some FS characteristics predict EEG abnormalities, they are not always associated with SES. We highlight the importance of performing an EEG in the group of children who had both FS and psychomotor retardation. This is most likely the group at the highest risk of developing epilepsy.

show abstract

“…It has been reported that EEG characteristics in FS can predict the development of epilepsy in the later stages (18). Kanemura et al (19,20) stated that epileptic activity in the frontal region had a significantly higher risk for the development of epilepsy than those with focal paroxysms in other regions.…”

Section: Discussionmentioning

confidence: 99%

Why do we do EEG? Experience of two years from a new pediatric neurology center

Tekin¹,

DURGUT²

2022

J Exp Clin Med

View full text Add to dashboard Cite

Electroencephalography (EEG) is very important for pediatric neurologists. The request reasons and results of EEGs from a newly established center were enrolled. Total of 2021 (1299 sleep + awake, 652 sleep, 70 awake) EEGs evaluated. Patients included 1005 girls and 1016 boys. 65% of the EEGs were normal and 30% was epileptic. Electroencephalography was performed due to epilepsy, fainting, first afebrile seizure, febrile seizure, speech retardation, dizziness, headache, movement disorders, gaze abnormalities, behavioral disorders, tremor, sleep disorders, tic, autism spectrum disorders, infantile spasm, encephalopathy, vision loss and abdominal pain in decreasing order. Significantly more common EEGs were performed due to tics (p:0,006), autism spectrum disorders (p:0,04) and speech retardation(p:<0,001) in boys and due to syncope (p:0,001) and dizziness(p:0,038) in girls. When EEG requests were examined by age groups, statistical significance was found. The EEG requests were parallel to the distribution of epileptic and non-epileptic events seen in that age group.

show abstract

Predictive value of paroxysmal EEG abnormalities for future epilepsy in focal febrile seizures

Cited by 13 publications

References 23 publications

Predictive Value of Epileptiform Discharges for Subsequent Epilepsy After Febrile Seizures

Predictive Value of Epileptiform Discharges for Subsequent Epilepsy After Febrile Seizures

Clinical Predictive Factors of Pathological EEG in Children with Febrile Seizures and Their Association with Subsequent Epileptic Seizures

Why do we do EEG? Experience of two years from a new pediatric neurology center

Contact Info

Product

Resources

About