Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid

Dawson, Audrey A.; Orr, J.A.

doi:10.1016/0360-3016(85)90174-9

Cited by 59 publications

(8 citation statements)

References 7 publications

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“…1,2 It is a slow-growing, generally well-circumscribed tumor that is treated primarily by surgical resection. 3À8 The rate of recurrence is exceptionally low at 1% to 5% in most modern surgical series, 4,5,7,8 and there does not seem to be a role for postoperative radiotherapy except in unusual circumstances. 4,8,9 The role of postoperative radiotherapy in the treatment of recurrent disease is controversial, 7,10À12 but there seems to be a subgroup of patients who may benefit from the use of this modality for their recurrent disease.…”

Section: Accepted 31 May 2001mentioning

confidence: 97%

“…3À8 The rate of recurrence is exceptionally low at 1% to 5% in most modern surgical series, 4,5,7,8 and there does not seem to be a role for postoperative radiotherapy except in unusual circumstances. 4,8,9 The role of postoperative radiotherapy in the treatment of recurrent disease is controversial, 7,10À12 but there seems to be a subgroup of patients who may benefit from the use of this modality for their recurrent disease. Patients in whom a complete surgical extirpation of their disease is not possible, 12 patients in whom sacrifice of the facial nerve is necessary for complete tumor removal, or patients in whom multiple recurrences have occurred seem to benefit from radiotherapy.…”

Section: Accepted 31 May 2001mentioning

confidence: 97%

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Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

et al. 2001

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Section: Accepted 31 May 2001mentioning

confidence: 97%

Section: Accepted 31 May 2001mentioning

confidence: 97%

Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

et al. 2001

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“…36 Radiation-induced transformation or progression of salivary gland tumors to a higher grade has been reported infrequently. [37][38][39] Non-radiation-related "dedifferentiation" of salivary gland tumors is also an uncommon phenomenon. 40,41 Whether histologic progression in the 2 cases we report was related to treatment with radiation is unclear.…”

Section: Casementioning

confidence: 99%

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Pelkey

Mills

1999

Am J Clin Pathol

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“…28 patients were applied 50-60Gy external beam radiotherapy whereas 4 patients underwent both brachytherapy and external beam radiotherapy. Despite the secondary malignancies in 4 patients (1%) (sarcoma after 14 years in one of them; adenocarcinoma in 2 patients in 18 and 30 years, respectively; and carcinoma ex pleomorphic adenoma in the fourth patient), this study has achieved a local control rate of 97% in 301 of 311 patients along with a local control rate of 92% in 20 years (10). A series of 34 patients with recurrence have been applied an average of 50Gy of RT at the University of California (between DISCUSSION the first and sixth recurrence) and the local control was reported to be 94% in 20 years in this study (11).…”

mentioning

confidence: 72%

Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature

2015

J Turgut Ozal Med Cent

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Pleomorphic adenoma is the most common benign salivary gland neoplasm (%75-80). It is found mostly in the parotid gland in middle-aged women. The optimal treatment is superficial or total parotidectomy with facial nerve preservation, which results in local control rates of 95% or higher. Radiotherapy (RT) is indicated for ositive margins, unresectable tumours, and multifocal recurrences after prior resection. Local control rates after RT for microscopic and gross residual tumour are approximately 80% to 85% and 40% to 60%, respectively. In this article, we share our experience of 2 cases of recurrent pleomorphic adenoma. Key Words: Pleomorphic Adenoma; Radiotherapy; Treatment.Parotis Pleomorfik Adenomunda Radyoterapinin Yeri: İki Olgu Sunumu ve Literatürün Gözden Geçirilmesi Özet Pleomorfik adenomlar tükrük bezlerinin en sık görülen iyi huylu neoplazmlarıdır (%75-80). Genelde orta yaşlı kadınlarda ve parotis bezinde bulunur. Optimal tedavi şekli fasial siniri koruyarak yapılan superfisyal veya total parotidektomidir. Cerrahi ile %95 ve üzerinde başarı vardır. Radyoterapi(RT) pozitif cerrahi sınırda, unrezektabl hastalıkta ve cerrahi sonrası multifokal nüksde kullanılır. RT sonrası lokal kontrol mikroskopik hastalıkta %80-85 ve gros rezidüel hastalıkta %40-60 arasındadır. Biz de bu makalede cerrahi sonrası nüks eden 2 olguyu adjuvan RT deneyimimizi paylaştık. Anahtar Kelimeler: Pleomorfik Adenom; Radyoterapi; Tedavi.Pleomorphic adenomas are the most common benign neoplasms of the salivary glands (75-80%) (1). The term pleomorphic defines the epithelial and connective tissue structures from which tumours originate. Although pleomorphic adenoma is often found in the parotid gland, it can also be seen in the submandibular, sublingual, or minor salivary glands. It is usually seen between 30-60 years of age and is more common in women than it is in men (2, 3). Patients usually present with complaints of painless, slow-growing masses. About 3-4% of pleomorphic adenomas can turn into carcinoma, causing metastases and even death (4). Rarely, benign pleomorphic adenomas can also metastasize (5). The etiology is unclear. A study conducted in Brazil on 60 submandibular pleomorphic adenoma cases reports negative results for both Ki-67 and p53 gene mutations (6). Hamada et al.'s study on 9 recurrent pleomorphic adenoma patients and 40 patients without recurrence after surgery examines mucin expressions like MUC1, MUC2, MUC4, MUC5AC, and MUC6 and, after observing increase in MUC1/DF3 expression (by p=0,011) in 4 of the 9 recurrent patients and 3 of the 40 patients without recurrence, it concludes that this indicator may be used as a marker in predicting recurrence after surgery (7).In this study, we aim to review 2 patients who experienced relapse after surgery along with a survey of the related literature.Case 1: A twenty-seven-year-old female patient was admitted to the hospital 6 years ago with swelling under the right ear. The CT imaging showed parotid masses. The patient underwent total parotidectomy due to paroti...

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Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid

Cited by 59 publications

References 7 publications

Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

Histologic Transformation of Polymorphous Low-Grade Adenocarcinoma of Salivary Gland

Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature

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