Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

Douglas, James; Einck, John; Austin-Seymour, Mary; Koh, Wui Jin; Laramore, George E.

doi:10.1002/hed.10027

Cited by 43 publications

(23 citation statements)

References 22 publications

(18 reference statements)

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“…The 10-year relapse-free survival rates were 62% for those treated with radiation for gross disease compared with 93% for those treated for subclinical disease (P ϭ 0.0005). Douglas et al 14 reported on 16 patients treated with neutron RT at the University of Washington (Seattle) between 1986 and 1993 and had a median follow up of 83 months. Ten patients had gross disease and 6 had subclinical disease at the time of RT.…”

Section: Discussionmentioning

confidence: 98%

Role of Radiotherapy for Pleomorphic Adenoma

Hodge

Morris²,

Werning³

et al. 2005

American Journal of Clinical Oncology

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The purpose of this article was to evaluate the role of radiotherapy (RT) in the treatment of pleomorphic adenoma. This is a retrospective analysis of 17 patients treated with RT alone (2 patients) or combined with surgery (15 patients). Follow up ranged from 1.8 to 27.1 years (median, 9.6 years). Local control was obtained in 8 of 10 patients (80%) with subclinical disease and 3 of 7 patients (43%) with gross disease. Overall local control was obtained in 11 of 17 patients (65%). The 5- and 10-year overall local control rates were 69% and 61%, respectively. One patient died secondary to tumor extension into the central nervous system, 1 patient had recurrence of carcinoma ex-pleomorphic adenoma and died of cancer at the primary site, 5 patients died free of disease, and 10 patients were alive at last follow up. RT is relatively effective at controlling subclinical disease in patients at high risk for developing recurrence after surgery for pleomorphic adenoma. Limited data suggest that RT may also occasionally control gross disease.

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Section: Discussionmentioning

confidence: 98%

Role of Radiotherapy for Pleomorphic Adenoma

Hodge

Morris²,

Werning³

et al. 2005

American Journal of Clinical Oncology

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“…Douglas et al 25 reported on 16 patients with recurrent and/or unresectable pleomorphic adenoma treated between 1986 and 1993 with neutron RT at the University of Washington (Seattle, WA). Indications for RT included gross residual disease, 10 patients; indeterminate margins, 2 patients; and/or multinodular recurrence, 9 patients.…”

Section: Radiotherapymentioning

confidence: 97%

Salivary Gland Pleomorphic Adenoma

Mendenhall

Mendenhall²,

Werning³

et al. 2008

American Journal of Clinical Oncology

117

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We discuss the optimal treatment and outcomes for pleomorphic adenoma of the salivary glands by reviewing the pertinent literature. Pleomorphic adenoma is the most common benign salivary gland neoplasm. It is found mostly in the parotid gland in middle-aged women. It progresses slowly and, left untreated, can produce significant morbidity and, rarely, death. The optimal treatment is superficial or total parotidectomy with facial nerve preservation, which results in local control rates of 95% or higher. Radiotherapy (RT) is useful to obtain local control in patients with positive margins, unresectable tumors, and multifocal recurrences after prior resection. Local control rates after RT for microscopic and gross residual tumor are approximately 80% to 85% and 40% to 60%, respectively. The main complication is surgically induced 7th nerve injury. Surgery is the mainstay of treatment and results in a very high cure rate. RT increases the likelihood of local control in the small subset of patients with incompletely resectable tumors and/or multifocal recurrences.

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“…Entretanto, não foi observada recidiva dos tumores considerados primários em nosso estudo, com acompanhamento mínimo de 38 meses e máximo de cinco anos. Esse fato pode ser atribuído ao tratamento cirúrgico com remoção total da glândula salivar acometida, aplicado à maioria dos tumores no HCP e preconizado na literatura (8,16,33) .…”

Section: Discussionunclassified

Estudo clinicopatológico de 106 adenomas pleomórficos de glândula salivar maior

Neves¹,

Lima²,

Sobral³

2007

J. Bras. Patol. Med. Lab.

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Introdução: O adenoma pleomórfico (AP) é o mais comum dos tumores das glândulas salivares. Transformação maligna pode ocorrer após recorrências ou em casos com longo tempo de evolução. Objetivo: Analisar os aspectos clinicoepidemiológicos e anatomopatológicos do AP de glândula salivar maior, principalmente os considerados indício de transformação maligna. Material e método: Foram avaliados 106 casos de AP pela pesquisa retrospectiva nos prontuários clínicos e revisão das preparações histológicas. Resultados: A média de idade dos pacientes foi de 39,51 anos, houve predomínio do sexo feminino (69,5%), a glândula parótida foi a mais acometida (86,8%) e o tempo de evolução foi superior a um ano em 76,74% dos casos, com tamanho tumoral de 3,48 cm em média. A avaliação histopatológica demonstrou cápsula tumoral incompleta e delgada em 49% dos casos. Protrusões para a cápsula ou extensão extracapsular foram infreqüentes, 11,32% e 8,49%, respectivamente. A matriz extracelular variou entre mixocondróide (41,5%), mixóide (36,8%), condróide (3,8%) e fibrótica (1,9%), tendo sido observadas associações entre os diversos tipos. O componente epitelial/mioepitelial constituiu 50% ou mais do tumor em 65,1% dos casos e estava disposto em arranjos cordonal (86,8%), ductal (81,1%), sólido (40,6%), cístico (20,7%) e em "paliçada" (8,49%). Metaplasia escamosa ocorreu em 16,04% dos casos. Alterações histopatológicas relacionadas com transformação maligna foram incomuns: hialinização extensa (4,7%) e necrose (0,9%

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Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands

Cited by 43 publications

References 22 publications

Role of Radiotherapy for Pleomorphic Adenoma

Role of Radiotherapy for Pleomorphic Adenoma

Salivary Gland Pleomorphic Adenoma

Estudo clinicopatológico de 106 adenomas pleomórficos de glândula salivar maior

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