Long-term results of classic antireflux surgery in 152 patients with Barrett's esophagus: Clinical, radiologic, endoscopic, manometric, and acid reflux test analysis before and late after operation

Csendes, Attila; Braghetto, Italo; Burdiles, Patricio; Puente, Guillermo; Korn, Owen; Díaz, Juan Carlos; Maluenda, Fernando

doi:10.1016/s0039-6060(98)70202-8

Cited by 175 publications

(123 citation statements)

References 51 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Antireflux surgery results in more reproducible and reliable elimination of reflux of acid and duodenal content 27,30 but might be more difficult to maintain in the long term in patients with Barrett esophagus vs those without. 31,32 Because the risk of progression to dysplasia and cancerinpatientswithmetaplasticcolumnarliningoftheesophagus depends on the presence of IM, 33 only patients with both features are presently enrolled in surveillance programs.…”

Section: Commentmentioning

confidence: 99%

Determinants of Intestinal Metaplasia Within the Columnar-Lined Esophagus

Öberg

Peters²,

DeMeester³

et al. 2000

Arch Surg

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 99%

Determinants of Intestinal Metaplasia Within the Columnar-Lined Esophagus

Öberg

Peters²,

DeMeester³

et al. 2000

Arch Surg

View full text Add to dashboard Cite

“…Treatment for adenocarcinoma of the esophagus is generally unsuccessful, with 5-year survival rates as low as 5% [9]. Aggressive therapy for gastroesophageal reflux disease with drugs or antireflux surgical procedures does not prevent BE or progression to cancer [10,11].…”

mentioning

confidence: 99%

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

Macfarlane

Furrie

Macfarlane

et al. 2007

Clinical Infectious Diseases

148

122

View full text Add to dashboard Cite

Background. Barrett's esophagus (BE) is a complication of chronic gastroesophageal reflux disease, in which patients are at greatly increased risk of esophageal dysplasia and adenocarcinoma. Over the past 2 decades, there has been an increase in the incidence of both BE and adenocarcinoma; however, the involvement of microorganisms in BE is uncertain. The aim of this study was to characterize microbial communities in esophageal aspirate specimens and on distal esophageal mucosal samples from patients with BE.Methods. Biopsy and aspirate specimens were obtained by endoscopic examination from 7 patients with BE and 7 control subjects without BE. Samples were cultured under aerobic, anaerobic, and microaerophilic conditions for yeasts and bacteria, including Helicobacter pylori. Bacterial isolates were identified by 16S ribosomal RNA gene sequencing. Fluorescence microscopic examination was also used to determine the spatial localization of these organisms on mucosal surfaces. Significant colonization was detected in 6 patients with BE and in 4 control subjects.Results. Overall, 46 bacterial species belonging to 16 genera were detected, with 10 species being common in both groups. Both aspirate and biopsy samples from patients with BE contained complex populations of bacteria. Uniquely, high levels of Campylobacter species (Campylobacter concisus and Campylobacter rectus), which have been linked to enteritis, periodontal infections, and tumor formation in animals, were found in 4 (57%) of 7 patients with BE but in none of the control subjects. Microscopic examination revealed that bacteria on mucosal biofilms often occurred in microcolonies.Conclusions. The occurrence of nitrate-reducing Campylobacter species in patients with BE may suggest that there is a link in either the initiation, maintenance, or exacerbation of disease processes leading to adenocarcinoma formation.

show abstract

“…This would also explain why the results of surgical treatment of patients with long Barrett's esophagus are worse than in patients with erosive esophagitis (12,30) .…”

Section: Discussionmentioning

confidence: 99%

What Is the Real Impairment on Esophageal Motility in Patients With Gastroesophageal Reflux Disease?

Falcäo

Nasi

Brandão

et al. 2013

Arq. Gastroenterol.

View full text Add to dashboard Cite

Context Impairment of esophageal motility is a common finding in patients with gastroesophageal reflux disease (GERD) as reduced lower esophageal sphincter (LES) basal pressure. A very low LES pressure might facilitate the occurrence of more gastroesophageal reflux whereas abnormal esophageal peristalsis may contribute to impaired esophageal clearance after reflux. Objective Evaluate the esophageal motor function of the lower esophageal sphincter and esophageal body in the various forms of gastroesophageal reflux disease. Methods The manometrics records of 268 patients, who had evaluation of the esophageal motility as part of the diagnostic gastroesophageal reflux disease were split into four groups, as follows: 33 patients who had no esophagitis; 92 patients who had erosive esophagitis; 101 patients who had short Barrett's esophagus and 42 patients who had long Barrett's esophagus. Results The group who had long Barrett's esophagus showed smaller mean LES pressure and higher percentage of marked LES hypotonia; in the distal segment of the esophageal body the this group showed higher percentage of marked hypocontractility of the distal segment (<30 mm Hg); this same group showed higher percentage of esophageal motility disorders. Conclusions The most intense esophageal motility disorders and lower pressure of lower esophageal sphincter were noted in the group with long Barrett's esophagus. Those with reflux esophagitis and short Barrett's esophagus had esophageal motility impairment, intermediate among patients with esophagitis and long Barrett's esophagus. Patients with typical symptoms of gastroesophageal reflux but without esophagitis by endoscopy study showed no impairment of esophageal motility.

show abstract

Long-term results of classic antireflux surgery in 152 patients with Barrett's esophagus: Clinical, radiologic, endoscopic, manometric, and acid reflux test analysis before and late after operation

Cited by 175 publications

References 51 publications

Determinants of Intestinal Metaplasia Within the Columnar-Lined Esophagus

Determinants of Intestinal Metaplasia Within the Columnar-Lined Esophagus

Microbial Colonization of the Upper Gastrointestinal Tract in Patients with Barrett's Esophagus

What Is the Real Impairment on Esophageal Motility in Patients With Gastroesophageal Reflux Disease?

Contact Info

Product

Resources

About