Long-term prognosis of patients having acute myocardial infarction when ≤40 years of age

Fournier, Juan A.; Cabezón, Soledad; Cayuela, Aurelio; Ballesteros, Sara; Cortacero, José A.P.F.; Llera, Luis S. Díaz de la

doi:10.1016/j.amjcard.2004.06.051

Cited by 100 publications

(78 citation statements)

References 24 publications

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“…Although previous studies have put forward data on coronary risk factors (6-9), long-term outcome of MI survivors (12,13), and extent of angiographic coronary lesions (9)(10)(11)14), we believe that the available data was not sufficient to provide adequate information about angiographic profile based on the type of acute coronary syndrome. In this regard, the present study provides valuable insights regarding the similarities and differences in coronary risk factors and angiographic characteristics in STEMI and NSTEMI/UA patients.…”

Section: Discussionmentioning

confidence: 82%

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Deora

Kumar

Ramalingam³

et al. 2016

Cardiovasc. Diagn. Ther.

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Background: Prevalence of acute coronary syndrome in young individuals is increasing progressively.Previous studies have focused on the analysis of risk factors and to some extent coronary angiographic profile in young vs. old patients with acute coronary syndrome, but no study compared the angiographic profile in young patients based on the type of acute coronary syndrome. So, this study was conducted to determine the differences in demographic and coronary angiographic profile of young patients with ST-elevated myocardial infarction (STEMI) vs. those with non-ST-elevated myocardial infarction (NSTEMI) or unstable angina (UA).Methods: We retrospectively analyzed young patients (age <40 years) with acute coronary syndrome who underwent coronary angiography at Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India between April 2010 and March 2011. Coronary risk factor profile and angiographic features were compared between STEMI and NSTEMI/UA patients.Results: Of 8,268 patients who underwent coronary angiography during the study period, 820 (~10%) were ≤40 year age. Of them, 611 exhibited STEMI and 209 exhibited NSTEMI/UA. Angiographic analysis revealed that single-vessel disease was significantly more common in the STEMI group (56.6% vs. 36.6% respectively; P<0.001) whereas triple-vessel disease was significantly more common in the NSTEMI/UA group (3.6% vs. 10.5% respectively; P<0.001). Conversely, left anterior descending coronary artery was more commonly involved in the STEMI group (55.3% vs. 40.2% respectively; P<0.001), whereas left circumflex coronary artery was more commonly involved in the NSTEMI/UA group (11.8 vs. 23.4% respectively; P<0.001). Of note, smoking/tobacco consumption was the most significant coronary risk factor with prevalence as high as 65% in both groups.Conclusions: In the present study, significant differences were observed in coronary risk factor profile and angiographic features between young patients with STEMI and NSTEMI/UA. Larger studies will be required to establish specific associations between presentation of acute coronary syndromes and angiographic profiles in young patients.

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Section: Discussionmentioning

confidence: 82%

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Deora

Kumar

Ramalingam³

et al. 2016

Cardiovasc. Diagn. Ther.

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“…1,14,15 It has been speculated that young patients have an improved survival rate compared with old patients because of less severe coronary artery involvement, 29,30 but recent reports have demonstrated that the long-term prognosis of young AMI patients is not benign, especially when there is low ejection fraction, previous MI, previous bypass surgery, or peripheral atherosclerotic disease. 31,32 However, there are no data on the medium-and long-term prognosis of young Japanese patients with AMI. In the present report, we have demonstrated for the first time that the medium-term prognosis in young AMI patients is comparable to that in nonyoung AMI patients in Japan, but the survival curves or event-free survival curves showed a slight, but not significant, difference approximately 2 years after discharge between the young and non-young groups.…”

Section: Discussionmentioning

confidence: 99%

Medium-Term Prognosis of Young Japanese Adults Having Acute Myocardial Infarction

Shiraishi

Kohno

Yamaguchi

et al. 2006

Circ J

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lthough young adults are a relatively small proportion of those having acute myocardial infarction (AMI), they are an important group to examine with regard to risk factor modification and secondary prevention. Previous studies have indicated that patients less than 40 years old comprise between 2% and 6% of all AMIs 1-3 and that AMI in young patients has different characteristics from that in older patients. Young AMI patients are characterized by a relatively high incidence of normal coronary arteries, non-obstructive stenosis, or single-vessel disease, 1,4,5 and high prevalence of current smoking, hyperlipidemia, and family history. 6,7 In addition, non-classical risk factors, such as vasospastic tendency, thrombophilic conditions, and past history of Kawasaki disease, have also been proposed as the cause of AMI in young patients. [8][9][10][11][12] Recently we demonstrated that young Japanese patients with AMI are usually male and have a high prevalence of cigarette smoking, hypercholesterolemia, and family history, a higher frequency of single-vessel disease, and a lower frequency of left circumflex coronary artery as the culprit lesion. 13 As to the short-and long-term prognosis, most previous reports have shown a favorable prognosis after discharge in young AMI patients, 1,14,15 and we have already shown that initial results of primary percutaneous coronary intervention (PCI) and in-hospital outcome in young patients with AMI are comparable to those in non-young patients with AMI in Japan. 13 However, the data on the medium-and long-term prognosis of young Japanese patients with AMI, aged <40 years, are still lacking. The AMI-Kyoto MultiCenter Risk Study, a large multicenter observational study in which 15 collaborating hospitals in Kyoto Prefecture have collected demographic, procedural, and outcome data on AMI patients, was established in 2000 in order to analyze these data and establish an emergency-hospital network for heart disease in Kyoto. The purpose of the present study is therefore to examine retrospectively the medium-term outcome in young adults with AMI in Japan. Methods Patient PopulationFrom January 2000 to Background Data on the medium-and long-term prognosis of young Japanese patients with acute myocardial infarction (AMI) are still lacking. Methods and ResultsIn the present study, 1,458 AMI patients were enrolled in the AMI-Kyoto Multi-Center Risk Study between January 2000 and December 2003. Of these, clinical characteristics and medium-term prognosis were retrospectively compared in 21 young patients <40 years (young group), and 190 non-young patients 60-70 years old (non-young group) who could be followed after hospital discharge. The young group was all male and had higher prevalence of current smoking and greater body mass index, but previous myocardial infarction (MI) and hypertension were more prevalent in the non-young group. The young group had a higher prevalence of single-vessel disease and a lesser incidence of left circumflex coronary artery as the culprit lesion. The acquis...

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“…8,15 The incidence of hypercholesterolemia or dyslipidemia in the published studies differs according to the criteria and ranges from 20% to nearly 75%. 6,9,10,13 The growth in the incidence rate of hypercholesterolemia over the years is mainly related with less restrictive criteria of its diagnosis. The role of with ACS were admitted to the hospital because of STEMI.…”

Section: Data Collectionmentioning

confidence: 99%

Treatment and outcomes of patients under 40 years of age with acute myocardial infarction in Poland in 2009-2013 (analysis from PL-ACS Registry)

Trzeciak¹,

Gierlotka²,

Poloński³

et al. 2017

Polish Archives of Internal Medicine

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Long-term prognosis of patients having acute myocardial infarction when ≤40 years of age

Cited by 100 publications

References 24 publications

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Demographic and angiographic profile in premature cases of acute coronary syndrome: analysis of 820 young patients from South India

Medium-Term Prognosis of Young Japanese Adults Having Acute Myocardial Infarction

Treatment and outcomes of patients under 40 years of age with acute myocardial infarction in Poland in 2009-2013 (analysis from PL-ACS Registry)

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