Long-term Outcomes of Cerebral Venous Sinus Stenosis Corrected by Stenting

Xu, Yaoming; Wang, Mengqi; Rajah, Gary; Ding, Yuchuan; Wu, Yan Yan; Wu, Yongfeng; Ji, Kangxiang; Wu, Chuanjie; Zhao, Wenbo; Ji, Xunming

doi:10.2174/1567202616666190206185133

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…), presented with very short segment of local stenosis in imaging, and tinnitus or idiopathic intracranial hypertension in clinical setting, which were corrected by stenting and obtained good outcomes. 22 However, whether the pathologic TS stenosis can affect the prognosis of ICH is still unclear, and our future study is still on going.…”

Section: Discussionmentioning

confidence: 94%

Anatomic Asymmetry of Transverse Sinus May Be Irrelevant to the Prognosis of Intracerebral Hemorrhage

Chen

Ding

et al. 2021

The Neurologist

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Background: We investigate the probable effect of anatomic asymmetry of transverse sinus (TS) on the outcomes of acute intracerebral hemorrhage (ICH), to provide reference for customized treatment. Methods: Consecutive patients with imaging-confirmed acute ICH were enrolled from October 2015 through October 2019, and divided into 2 groups: symmetrical and unilateral (left or right) slender TS groups, based on the status of TS in imaging maps. Brain computed tomography (CT) maps of all patients at baseline and half-month post-ICH were obtained, and the volumes of hematoma and the perihematomal edemas (PHE), as well as the modified Rankin Scale (mRS) scores at the month-3 post-ICH between the 2 groups were assessed and analyzed. Results: A total of 46 eligible patients entered into final analysis, including 18 cases in the slender TS group (14 cases involved the left side while 4 cases involved the right side), and 28 cases in the symmetrical TS group. The mRS scores, hematoma absorption rates, and the residual volumes of PHE of all patients in the 2 groups at half-month post-ICH showed no statistical significance (all P >0.05), and all of the items mentioned above were related to the hematoma volume at baseline (all P <0.001). At the month-3 follow-up post-ICH, the mRS scores between the 2 groups showed no statistical significance as well ( P =0.551). Conclusions: Anatomic asymmetry of TS may not affect the prognosis of PHE and clinical outcome after ICH.

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Section: Discussionmentioning

confidence: 94%

Anatomic Asymmetry of Transverse Sinus May Be Irrelevant to the Prognosis of Intracerebral Hemorrhage

Chen

Ding

et al. 2021

The Neurologist

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“…In this study, we found that stenting could improve the anxiety and depression scores. Previous studies also showed that stent therapy could improve cerebral hypoperfusion and long-term outcomes in patients with CVSS or IJVS [ 41 , 42 , 43 ]. These findings may reveal an internal link between anxiety and depression symptoms, cloudy-like WMLs, and CVOD-mediated hypo-perfusion in patients with CVOD.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Venous-Associated Brain Damage May Lead to Anxiety and Depression

Lan

Song

Jia

et al. 2022

JCM

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Background and purpose: Anxiety and depression are common in patients with Cerebral venous outflow disturbance (CVOD). Here, we aimed to explore possible mechanisms underlying this phenomenon. Methods: We enrolled patients diagnosed with imaging-confirmed CVOD, including internal jugular venous stenosis (IJVS) and cerebral venous sinus stenosis (CVSS) between 2017 and 2020. All of them had MRI/PWI scans. The Hamilton Anxiety Scale (HAMA) and 24-item Hamilton Depression Scale (HAMD) were used to evaluate the degree of anxiety and depression at the baseline and three months post-stenting. In addition, the relationships between the HAMA and HAMD scores, white matter lesions, and cerebral perfusion were analyzed using multiple logistic regressions. Results: A total of 61 CVOD patients (mean age 47.95 ± 15.26 years, 59.0% females) were enrolled in this study. Over 70% of them reported symptoms of anxiety and/or depression. Severe CVOD-related anxiety correlated with older age (p = 0.046) and comorbid hyperlipidemia (p = 0.005). Additionally, head noise, sleep disturbances, and white matter lesions (WMLs) were common risk factors for anxiety and depression (p < 0.05). WMLs were considered an independent risk factor for anxiety based on multiple regression analysis (p = 0.029). Self-contrast displayed that CVOD-related anxiety (p = 0.027) and depression (p = 0.017) scores could be corrected by stenting, as the hypoperfusion scores in the limbic lobes of patients with anxiety and depression were significantly higher than those in patients without. Conclusions: CVOD-induced hypoperfusion-mediated changes in the white matter microstructure may represent an underlying mechanism of anxiety and depression in patients with chronic CVOD.

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“…Previous studies found that IIH involved more common in obese women and was poor response to medication treatment (3,4). However, increasing studies in recent years revealed that CVS stenosis might be one of the major etiologies of refractory IIH, and further, it is worth noting that cerebral sinus stenting can significantly reduce ICP and obtain relief of clinical symptoms accordingly (11)(12)(13). Therefore, CVS stenosis received increasing attention as a potential cause of IH (7,14).…”

Section: Cvs Stenosis and Idiopathic Intracranial Hypertension (Iih)mentioning

confidence: 99%

Perioperative mannitol intensive use may avoid the early complication of cerebral venous sinus stenting

Bai¹,

Chen²,

Wu³

et al. 2020

Ann Transl Med

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Background: Cerebral venous sinus (CVS) stenting has been widely applied for correcting CVS stenosis.However, there are still some potential complications. The purpose of this study is to investigate the impact of perioperative management on avoiding complications of CVS stenting.Methods: Patients confirmed as CVS stenosis were enrolled from January 2014 through November 2019. All CVS stenosis were corrected by stenting when the trans-stenotic mean pressure gradient (MPG) was up to or over 8 mmHg. Patients were divided into perioperative management group and control group. Patients in the former group underwent transiently mannitol 250 mL intravenous infusion immediately prior to stenting besides routine ICP control. While patients in control group underwent the same routine treatment as in the perioperative management group. The clinical symptoms, intracranial pressure (ICP), and MPG of the patients were compared before and after stenting. In addition, the complications between the two groups were compared.Results: A total of 81 eligible patients were finally enrolled in this study, including 64 females and 17 males, mean aged 45.35±13.83 years. After stenting, the stenotic CVS restored normal blood flow and MPG decreased significantly [

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Long-term Outcomes of Cerebral Venous Sinus Stenosis Corrected by Stenting

Cited by 10 publications

References 19 publications

Anatomic Asymmetry of Transverse Sinus May Be Irrelevant to the Prognosis of Intracerebral Hemorrhage

Anatomic Asymmetry of Transverse Sinus May Be Irrelevant to the Prognosis of Intracerebral Hemorrhage

Cerebral Venous-Associated Brain Damage May Lead to Anxiety and Depression

Perioperative mannitol intensive use may avoid the early complication of cerebral venous sinus stenting

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