Long-term histological and mucin alterations in the neobladder mucosa following urinary bladder augmentation or substitution with gastrointestinal segment

Kispal, Zoltan Farkas; Kardos, Dániel; Jilling, Tamás; Kereskai, László; Isaacs, Marla; Balogh, Daniel L.; Pintér, Andrew; Till, Holger; Vajda, Péter

doi:10.1016/j.jpurol.2015.04.037

Cited by 8 publications

(7 citation statements)

References 20 publications

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“…Accordingly, other genera found in the samples of this study correspond to published results on the human bladder microbiome [24]. A further question arising is whether or not the local microbiome plays any role in histological and mucin alterations, particularly in premalignant or malignant transformation [28]. To answer this question, the authors are planning to correlate the microbial changes with the histological alterations in a larger prospective and multicenter study.…”

Section: Discussionsupporting

confidence: 76%

The local microbiome after pediatric bladder augmentation: intestinal segments and the native urinary bladder host similar mucosal microbiota

Kispal

Vajda

Kardos

et al. 2019

Journal of Pediatric Urology

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Section: Discussionsupporting

confidence: 76%

The local microbiome after pediatric bladder augmentation: intestinal segments and the native urinary bladder host similar mucosal microbiota

Kispal

Vajda

Kardos

et al. 2019

Journal of Pediatric Urology

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“…Dysplasia was detected mainly in the anastomotic region. The malignancy was detected 11 years after the augmentation procedure ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our initial strategy was to investigate those patients with cystoscopic examinations in late postoperative period. However, due to recent publications and our experience, we changed our approach ( 5 , 6 ). Our recent protocol is to perform cystoscopy only in symptomatic patients (e.g.…”

Section: Discussionmentioning

confidence: 99%

Transition to adulthood with a bladder augmentation: histopathologic concerns

Mammadov¹,

Dervışoğlu

Eliçevik

et al. 2017

Int. braz j urol.

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Aim:To investigate the histopathologic changes in native bladder and gastrointestinal segment, the relation between histopathologic changes, type of operation and the period passed over operation in patients with bladder augmentation.Materials and methods:Twenty consecutive patients were enrolled in this study. Histopathologic evaluation of the cystoscopic mucosal biopsies from native bladder and enteric augment was performed in all patients.Results:Active or chronic non-specific inflammation of various degrees was found in all specimens except two. Metaplastic changes were detected in 3 patients. Two patients had squamous metaplasia (one focal, one extensive) and one patient had intestinal metaplasia. All metaplastic changes were found in native bladder specimens. The type of augmentation in patients with metaplastic changes were ileocystoplasty and sigmoidocystoplasty. No signs of malignancy were detected in any patient.Conclusion:The complexity of the disorders requiring bladder augmentation does not let the surgeons to draw a clear line between different groups of complications including malignancy formation. However, due to challenging course of the augmentation procedure itself, surgeons should be well aware of the possibility of malignancy development.

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“…When investigating histological changes in urinary diversions and their association with mucin gene expression (MUC1 and MUC2) in children and adolescents submitted to gastrocystoplasty, ileocystoplasty and colocystoplasty between 1988 and 2013 19 , observed an adenocarcinoma in the intestinal segment of the colocystoplasty of an 11-year old child, with upregulated MUC1 expression and downregulated MUC2 expression due to dysplasia. The authors identified these changes as promising early markers of neoplasia in colocystoplasty.…”

Section: ■ Discussionmentioning

confidence: 99%

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

Santos

Coelho²,

Azevedo³

et al. 2017

Acta Cir. Bras.

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Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L-lysine 1 5-Experimental SurgeryActa Cir Bras. 2017;32(3):297-306 Abstract Purpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks.Results: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0.045). No inflammatory cells, dysplasia or abnormalities were observed. Staining with Alcian blue revealed a substantial reduction of goblet cells and mucins in the colon segment (Groups A and B). Conclusion:The administration of L-lysine to rats accelerated the development of transitional metaplasia in the epithelium of the colon segment in cystoplasty.

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Long-term histological and mucin alterations in the neobladder mucosa following urinary bladder augmentation or substitution with gastrointestinal segment

Cited by 8 publications

References 20 publications

The local microbiome after pediatric bladder augmentation: intestinal segments and the native urinary bladder host similar mucosal microbiota

The local microbiome after pediatric bladder augmentation: intestinal segments and the native urinary bladder host similar mucosal microbiota

Transition to adulthood with a bladder augmentation: histopathologic concerns

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

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