Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF)

Passeri, Elodie; Villa, Chiara; Couette, Maryline; Itti, Emmanuel; Brugières, Pierre; Césaro, P.; Gherardi, Romain K.; Bachoud‐Lévi, Anne‐Catherine; Authier, François‐Jérôme

doi:10.1016/j.jinorgbio.2011.08.006

Cited by 47 publications

(35 citation statements)

References 37 publications

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“…MMF-associated cognitive dysfunction resembles that observed after chronic exposure to aluminum and in patients infected with hepatitis C virus or HIV (7). At follow-up, it appears stable over time, both in structure and in severity (11). The neuropsychological profile of MMF-associated cognitive dysfunction suggests underlying cortico-subcortical brain lesions, possibly of inflammatory or toxic origin.…”

mentioning

confidence: 75%

“…Cognitive performance in MMF was shown to be independent of depression level (7) or psychotropic drug intake (11). All patients with significant cognitive impairment (subgroups 2, 3, and 4) displayed marked deficits in executive functions, notably affecting inhibition, flexibility, and working memory, as well as difficulties in selective attention.…”

Section: Discussionmentioning

confidence: 98%

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Gucht¹,

Sebaiti²,

Guedj³

et al. 2016

J Nucl Med

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The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18 F-FDG. Methods: 18 F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean 6 SD], 45.9 6 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18 F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 6 16 y; P 5 0.87) and sex (73% women; P 5 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n 5 42), those with frontal subcortical (FSC) dysfunction (n 5 29), those with Papez circuit dysfunction (n 5 22), and those with callosal disconnection (n 5 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P , 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.

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confidence: 75%

Section: Discussionmentioning

confidence: 98%

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Gucht¹,

Sebaiti²,

Guedj³

et al. 2016

J Nucl Med

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“…Aluminum has been identified as a factor in chronic fatigue syndrome [92], and it is known to have extensive negative impact on the brain [93][94][95][96][97][98][99][100][101], if it cannot be properly disposed of by the body. Patients with macrophagic myofasciitis often experience cognitive and memory deficits in addition to chronic fatigue.…”

Section: Necrosis and Autoimmune Reactionsmentioning

confidence: 99%

“…For these patients, vaccine-derived aluminum hydroxide can persist longterm in the brain in association with chronic cognitive dysfunction [95]. Recent experimental studies have confirmed that nanosized aluminum-containing particles are phagocytosed by macrophages and can be transported into the brain via the lymph nodes in a Trojan horse mechanism [97], and this mechanism was proposed to explain observed cognitive dysfunction in association with aluminuminduced macrophagic myofasciitis. In a mouse model, alum brain levels peak 2-3 days following injection of alum adjuvants [102].…”

Section: Necrosis and Autoimmune Reactionsmentioning

confidence: 99%

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

Seneff

Davidson²,

Liu

2012

Entropy

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Abstract:In a recent paper, we proposed that a contributing factor in autism is a deficiency in cholesterol sulfate supply. In this paper, we investigate a link between preeclampsia and subsequent autism in the child, and we hypothesize that both conditions can be attributed to a severe depletion of cholesterol sulfate. Through studies on the Vaccine Adverse Event Reporting System (VAERS) database, we demonstrate a strong statistical relationship among the signs and symptoms associated with autism and those associated with preeclampsia, pernicious anemia, and serious adverse reactions to vaccines. We show that VAERS reports associated with symptoms typical of pernicious anemia produce both a set of symptoms that are highly correlated with preeclampsia and another set highly correlated with autism. We explain this observation via an argument that, in a severe reaction, the cascade of events subsequent to vaccination reflects a profuse production of nitric oxide (NO) and consequential destruction of both red blood cells (RBCs) and cobalamin. This may explain the diverse signs and symptoms associated with both preeclampsia and severe vaccine adverse reactions. We argue that excess NO synthesis, induced by the aluminum and antigen in vaccines, results in hemolysis of RBCs, which allows hemoglobin to scavenge the excess NO, converting it to nitrate. The NO is also scavenged by cobalamin, leading to its inactivation and contributing to subsequent pernicious anemia. Finally, we demonstrate that severe adverse reactions to vaccines can be associated with life-threatening conditions related to the heart and brain, as well as OPEN ACCESSEntropy 2012, 14 2266 stillbirth, when the vaccine is administered to a woman in the third-trimester of pregnancy, as demonstrated by statistical analysis of the Gardasil records.

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“…Вместе с тем существование определенных проблем без-опасного применения адъювантов на основе солей алюминия вызывает необходимость разработки новых перспективных адъювантов, отвечающих повышенным требованиям безопас-ности [14,15].…”

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Carbohydrate-Based Adjuvants for Vaccine Production

Курашова¹,

Dzagurova²,

Ishmukhametov³

et al. 2018

Biopreparaty. Profilaktika, diagnostika, lechenie

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Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF)

Cited by 47 publications

References 37 publications

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

Carbohydrate-Based Adjuvants for Vaccine Production

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Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF)

Cited by 47 publications

References 37 publications

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

Carbohydrate-Based Adjuvants for Vaccine Production

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Product

Resources

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis