Long-term exposure to air pollution and risk of incident inflammatory bowel disease among middle and old aged adults

Particulate matter exposure may increase the risk of irritable bowel syndrome: a large-scale prospective study based on the UK Biobank

“…Furthermore, we also investigated the impact of PM 10 and PM 2.5–10 on the incidence of IBS. A previous study had estimated the risk of inflammatory bowel disease (IBD) associated with an IQR increase in long-term PM 2.5 exposure, 7 which is also comparable with the results in our study. Consistent with a previous study on the association between long-term PM 2.5 exposure and incidence risks of esophageal cancer, 5 we also estimated almost linear exposure–response curves for the association between long-term PM 2.5 and PM 10 exposure and IBS, which indicates that the incidence risk of IBS increased with higher levels of PM.…”

“…15 Therefore, gastrointestinal exposure is an important exposure route for PM. Several previous studies have linked PM exposure with increased risks of gastrointestinal diseases such as oesophageal cancer, IBD, and IBS, 5,7,26,27 It is reported that PM exposure could increase ROS generation, induce gastrointestinal epithelial cell death, and induce the disruption and hyperpermeability of the intestinal barrier. 34,35 Moreover, animal studies observed that PM exposure was associated with increased inflammatory cell infiltration, inflammation-related genes ( IL-6 , IL-10 , IL-1β , and TNF-α ) expression, and intestinal inflammation in the colon, 35–37 which provided experimental evidence on the association between PM exposure and intestinal inflammation.…”

“…3,4 Apart from the common risk factors, ambient air pollution, especially particulate matter (PM), has been linked with a wide range of gastrointestinal diseases. [5][6][7] However, no sufficient evidence has demonstrated the association between PM exposure and the incidence risk of IBS.…”

“…5,6 Moreover, PM exposure is also linked to an increased risk of lower gastrointestinal diseases such as inflammatory bowel disease, and appendicitis. 7,16 However, the impact of PM in different sizes on the gastrointestinal tract has not been elucidated. Large-scale cohort studies evaluating the effect of long-term PM exposure on IBS are limited.…”

Klimakrise: Welche gastroenterologischen Folgeerkrankungen dieses medizinischen Notfalls sollten wir kennen?

“…Bei den multifaktoriell bedingten chronisch-entzündlichen Darmerkrankungen (CED) hat die Umwelt einen erheblichen Einfluss auf deren Entstehung, darunter sind auch klimatische Bedingungen und Luftverschmutzung von Bedeutung [26,27,28,29].…”