Long-term evolution and predictive factors of mild inflammatory bowel disease

Reenaers, Cathérine; Pirard, C.; Vankemseke, C.; Latour, Philippe; Bélaïche, Jacques; Louis, Édouard

doi:10.3109/00365521.2015.1128965

Cited by 13 publications

(12 citation statements)

References 28 publications

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“…However, our study differed from that study (Reenaers et al 2016 ). First, we focused on CD and we assessed disease activity regularly, using the CDAI, which is a well-established research tool.…”

Section: Discussioncontrasting

confidence: 79%

“…As far as we know, only one study has described the evolution of mild IBD; it analyzed the clinical significance and factors associated with inflammatory bowel disease that was considered to be mild 1 year after diagnosis (Reenaers et al 2016 ). In that study, 90 % of CD patients lost their mild disease status over time (Reenaers et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…Little information is available on the progression of mild CD and the factors associated with long-term mild IBD (Cosnes et al 2012 ; Reenaers et al 2016 ). This study was conducted to investigate the course of mild CD in a hospital-based cohort.…”

Section: Introductionmentioning

confidence: 99%

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Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

et al. 2016

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BackgroundFew studies have been conducted on the progression of mild Crohn’s disease (CD). We aimed to investigate the natural course in mild CD patients with or without bowel damage, to identify predictors of bowel resection and to calculate the requirement for rescue medication.MethodsA total of 104 patients with mild activity (150 < CDAI < 220) with or without bowel damage were identified from among 1050 CD patients between January 2008 and May 2014. Univariate and multivariate analysis was used to identify factors associated with bowel resection. The cumulative probabilities of bowel resection and rescue medication such as steroids or anti-TNF agents were calculated.ResultsThe median follow-up duration was 28.2 months (IQR 26.7). Cumulative probabilities of bowel resection were 0.2, 11.8 and 42.4 % at 1, 3 and 5 years respectively. The CD patients with bowel damage had a higher bowel resection rate than those without bowel damage (P < 0.001). The cumulative probabilities of corticosteroid-requirement were 3.0, 19.6 and 78.4 % of patients at 1, 3 and 5 years, respectively, and 2.1, 11.9 and 56.1 %, in terms of the cumulative probabilities of requiring anti-TNF agents. Patients with elevated CRP (>1.6 mg/dL) were more likely to undergo bowel resection (P = 0.032).ConclusionsEven in CD patients with mild disease activity, the cumulative probability of bowel resection is not low if they have bowel damage or elevated CRP at baseline. Mild CD patients with bowel damage or elevated CRP at baseline need special attention.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

et al. 2016

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“…UC tended to have higher incidence rate of DM than control subjects. Because age modified risk of extraintestinal manifestations 24 and disease severity 25 in previous studies, we also stratified patients by age. The DM incidence rate of UC was consistently higher than that of the control subjects in respective age groups.…”

Section: Resultsmentioning

confidence: 99%

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Tseng

Chang

Liao

et al. 2016

Sci Rep

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On a molecular level, two autoimmune diseases: ulcerative colitis (UC) and dermatomyositis share common genetic determinants. On a clinical level, case reports evidenced the co-occurrence of these two diseases. We therefore hypothesize that UC is potentially associated with increased cumulative incidence of dermatomyositis. The goals of this retrospective cohort study were to evaluate whether UC is associated with increased cumulative incidence of dermatomyositis independent of sex and age. For comparison, we also assessed the cumulative incidence of polymyositis in UC and control subjects. The study enrolled 3,133 UC subjects and 14,726 control subjects. The cumulative incidence of dermatomyositis was significantly higher in UC than that of control subjects (p = 0.026), but the cumulative incidence of polymyositis was comparable between UC and control subjects (p = 0.596). UC was independently associated with the increased incident dermatomyositis (hazard ratio: 6.19, 95% confidence interval = 1.77–21.59, p = 0.004) after adjusting for sex, age, and concomitant rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis. Similar trends of increased dermatomyositis in UC were observed when patients were stratified based on sex and age. In conclusion, our findings suggest that UC is probably associated with increased cumulative incidence of dermatomyositis, independent of sex, age, and concomitant autoimmune diseases.

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“…A Probabilité de guérison spontanée àd eux semaines=4 % [ 42]. A Probabilité pré-test de faible évolutivité dans l'année =1 47/463= 32% [43]. A La plupart des cas vont se compliquer d'une sténose ou d'une perforation dans les 3 à 5a ns [44].…”

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La méthode Bayésienne pour aider à évaluer l’efficacité des thérapies personnalisées

Donatini¹

2017

Hegel

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Long-term evolution and predictive factors of mild inflammatory bowel disease

Abstract: Background Crohn's disease (CD) and ulcerative colitis (UC) are potentially progressive diseases. Few data are available on the prevalence and the factors associated with mild inflammatory bowel diseases (IBD).

Cited by 13 publications

References 28 publications

Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

La méthode Bayésienne pour aider à évaluer l’efficacité des thérapies personnalisées

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