Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

Kwak, Min Seob; Kim, Kyung‐Jo; Park, Sang Hyoung; Yang, Dan; Ye, Byong Duk; Myung, Seung‐Jae; Yang, Suk‐Kyun

doi:10.1186/s40064-016-2606-6

Cited by 2 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These different correlations may be due to the poor agreement among clinical, endoscopic and histological activity in IBD patients [27]. Numerous studies have shown the correlation of disease activity with inflammatory markers was much stronger for CD than for UC [14,28,29]. Similarly, we found ACK1 expression correlated less well with clinical activity in UC relative to CD.…”

Section: Discussionmentioning

confidence: 50%

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Zhao

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

BackgroundActivated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity.Material/MethodsA total of 250 individuals who underwent total colonoscopy were collected randomly from January 2007 to May 2013 in Nanfang Hospital, Guangzhou, China. Colorectal mucosal biopsy specimens were obtained by endoscopy from 78 patients with ulcerative colitis (UC), 22 with Crohn’s disease (CD), 20 with infectious colitis, 26 with non-IBD and noninfectious colitis, 16 with sporadic adenomas, 4 with dysplasia-associated lesions or masses, 10 with sporadic colorectal cancer (CRC), 4 with UC-related CRC, 10 with hyperplastic polyps, and 60 without colonic abnormalities. ACK1 protein levels were determined immunohistochemically. The correlations of ACK1 expression with disease activity and severity were also evaluated.ResultsSignificantly increased ACK1 expression was observed in epithelial cells of colorectal mucosa with inflammation and dysplasia compared to controls (P<0.05). ACK1 expression correlated with clinical activity in IBD (χ2=4.57, P=0.033 for UC; χ2=5.68, P=0.017 for CD), as well as grade of dysplasia in preneoplastic lesions (P<0.05). No significant differences in ACK1 expression were found between UC and CD, or between IBD and non-IBD conditions (P>0.05).ConclusionsACK1 protein is increased extensively in colitis and colorectal dysplasia. ACK1 overexpression may play a role in colorectal inflammation and neoplasms.

show abstract

Section: Discussionmentioning

confidence: 50%

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Zhao

et al. 2016

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…[ 15 ] According to previous reports, increased CRP levels in patients with CD in clinical remission is associated with increased subsequent disease activity, and a significantly increased need for hospitalization and surgical treatment related to CD. [ 16 , 17 ] The CRP level reflects the current condition of CD, and has utility as a biomarker predicting the subsequent prognosis. The present study showed significant correlations between the CRP level and the CDAI and IOIBD in patients with CD without enterostomy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the modified Crohn's disease activity index in patients with Crohn disease with enterostomy

Ishida¹,

Miyazu²,

Suzuki³

et al. 2021

Medicine

View full text Add to dashboard Cite

Although the Crohn's Disease Activity Index (CDAI) is often used to evaluate the disease activity in Crohn's disease (CD), the number of liquid or soft stools cannot be precisely evaluated, and thus accurate scores cannot be calculated, in patients with enterostomy. Therefore, we created the modified CDAI (mCDAI), without the defecation frequency item from the CDAI, and examined its usefulness. Study participants comprised 9 patients with CD with enterostomy and 20 patients with CD without enterostomy. Correlations between the mCDAI and serum albumin (Alb) levels or C-reactive protein (CRP) levels were examined using regression analysis. Additionally, regression analyses were conducted in patients with CD without enterostomy to determine the Alb and CRP levels corresponding to the CDAI at its cutoff value for remission status (150). The obtained values were applied to the mCDAI regression equations to determine the equivalent mCDAI cutoff value. mCDAI and Alb levels were significantly negatively correlated (P < .0001). The mCDAI had a significant positive correlation with the CRP level and erythrocyte sedimentation rate (P = .0061 and P = .0133, respectively). From the regression analysis of patients with CD without enterostomy, the Alb and CRP levels equivalent to a CDAI of 150 were 3.85 g/dL and 0.62 mg/dL, respectively. When applying these values to the mCDAI regression formulas, the values of 113.8 and 115.2, respectively, were obtained. Thus, the cutoff value of the mCDAI indicating disease activity was estimated as 115. The mCDAI fully reflects the nutritional status and inflammatory response, and is convenient and useful for assessing disease activity over time, in patients with CD with enterostomy. A mCDAI score ≥ 115 indicates disease activity.

show abstract

Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

Cited by 2 publications

References 30 publications

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms

Evaluation of the modified Crohn's disease activity index in patients with Crohn disease with enterostomy

Contact Info

Product

Resources

About