Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Tseng, Chia‐Chun; Chang, Shun‐Jen; Liao, Wei‐Ting; Chan, Ya-Ting; Tsai, Wen‐Chan; Ou, Tsan‐Teng; Wu, Chuan-Chun; Sung, Wan‐Yu; Hsieh, Ming‐Chia; Yen, Jeng‐Hsien

doi:10.1038/srep28175

Cited by 10 publications

(6 citation statements)

References 46 publications

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“… 19 In adult studies, the incidence of DM is higher in patients with ulcerative colitis (UC) compared to control groups, and the presence of UC may actually be a risk factor for DM. 20 Given that the entire clinical picture is compatible with JDM, and that there are no reports of mesalazine inducing JDM, her disease was likely not drug-induced. As a precaution, our patient discontinued mesalazine and continued MTX, high-dose prednisone, IVIG, and hydroxychloroquine to treat her colitis, skin manifestations, and myositis.…”

Section: Discussionmentioning

confidence: 98%

A rare case of suspected lupus erythematosus panniculitis as the presenting skin feature of juvenile dermatomyositis: A case report

Ginter

Ramien

Bründler

et al. 2022

SAGE Open Medical Case Reports

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Juvenile dermatomyositis is a rare autoimmune myopathy of childhood, associated with systemic vasculopathy, primarily affecting the capillaries. Panniculitis is seen histologically in about 10% of patients with dermatomyositis; however, its clinical presentation is rare, with only 30 cases presented in the literature to date. The histopathology overlaps with other inflammatory disease states, and is almost identical to the panniculitis seen in lupus erythematous panniculitis. In the cases with both panniculitis and dermatomyositis, skin and muscle inflammation is usually the first clinical manifestation. We present a case of a 16-year-old female with panniculitis as the initial presenting feature of juvenile dermatomyositis in the context of a prior diagnosis of indeterminate colitis.

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Section: Discussionmentioning

confidence: 98%

A rare case of suspected lupus erythematosus panniculitis as the presenting skin feature of juvenile dermatomyositis: A case report

Ginter

Ramien

Bründler

et al. 2022

SAGE Open Medical Case Reports

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“…Apart from GMS, orbital myositis, which is currently considered as a subtype of idiopathic orbital inflammation, has also been reported in patients with IBD, mainly CD[ 5 ]. Few cases of dermatomyositis (DM) and polymyositis have also been described during the course of IBDs and a recent study showed that DM was more frequent in ulcerative colitis patients than CD patients and control subjects[ 7 ]. Nevertheless, the true incidence of IM occurring in this context is probably underestimated as myalgia can be confused with joint manifestations or with non-inflammatory muscle disorders ( e.g.…”

Section: Discussionmentioning

confidence: 99%

Crohn’s disease-related ‘gastrocnemius myalgia syndrome’ successfully treated with infliximab: A case report

Catherine¹,

Kadhim²,

Lambot³

et al. 2022

WJG

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BACKGROUND Extra-intestinal manifestations in inflammatory bowel diseases (IBD) are frequent and involve virtually all organs. Conversely, the clinical characteristics and course of inflammatory myopathies in IBD remain poorly described and mostly related to orbital myositis. Moreover, alternative therapeutic strategies in non-responder patients to corticosteroid therapy must still be clarified. CASE SUMMARY A 33-year-old woman with a history of unclassified colitis presented with acute bilateral calf pain. On admission, her clinical and biological examinations were non-specific. However, magnetic resonance imaging showed bilateral inflammatory changes in gastrocnemius muscles suggestive of myositis. Muscle biopsy confirmed the diagnosis of myositis and demonstrated an inflammatory infiltrate mainly located in the perimysial compartment including lympho-plasmocytic cells with the formation of several granulomatous structures while the endomysium was relatively spared. The combined clinical, biological and histomyopathological findings were concordant with the diagnosis of ‘gastrocnemius myalgia syndrome’ (GMS), a rare disorder associated with Crohn’s disease (CD). Ileocolonoscopy confirmed CD diagnosis and systemic corticosteroids (CS) therapy was started, resulting in a rapid clinical improvement. During CS tapering, however, she experienced a relapse of GMS together with a severe active ileocolitis. Infliximab was started and allowed a sustained remission of both conditions at the latest follow-up (20 mo). CONCLUSION The GMS represent a rare CD-associated inflammatory myopathy for which anti-tumour necrosis factor-α therapy might be considered as an effective therapeutic option.

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“…IBD can be associated with DM[ 6 , 7 ]. The results of Tseng et al [ 16 ] showed that the cumulative incidence of DM in patients with UC is higher than that of the control group, and UC is positively correlated with DM. We suspect that their correlation is caused by their similar mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis: A case report

Huang

Han

Liu

et al. 2020

WJG

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BACKGROUND Joint, skin, oral cavity, and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its onset. The cases of ulcerative colitis with dermatomyositis (DM) are rare. In this study, we report a rare case of ulcerative colitis with DM that was effectively treated with infliximab. CASE SUMMARY The patient was a 57-year-old female with a 2-year history of DM. The patient was admitted to hospital with abdominal pain, diarrhea, and blood in stool lasting for more than 2 mo. Colonoscopy revealed multiple erosions and ulcers in the entire colon and rectum. Pathological sections showed chronic inflammatory cell infiltration, especially neutrophil infiltration, in the colonic mucosa; therefore, the patient was diagnosed with ulcerative colitis. Preparations of 5-aminosalicylic acid was added to her treatment based on the original treatment for DM, but its effect was unsatisfactory. The patient’s discomfort was relieved after infliximab treatment. CONCLUSION Infliximab can improve DM in the treatment of ulcerative colitis. Specialists need to raise awareness about patients with inflammatory bowel disease who have rare extraintestinal manifestations.

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Increased Cumulative Incidence of Dermatomyositis in Ulcerative Colitis: a Nationwide Cohort Study

Cited by 10 publications

References 46 publications

A rare case of suspected lupus erythematosus panniculitis as the presenting skin feature of juvenile dermatomyositis: A case report

A rare case of suspected lupus erythematosus panniculitis as the presenting skin feature of juvenile dermatomyositis: A case report

Crohn’s disease-related ‘gastrocnemius myalgia syndrome’ successfully treated with infliximab: A case report

Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis: A case report

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