Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms

Abstract

ERr 731 is effective and safe in the long-term treatment of menopausal symptoms in perimenopausal women.

Effects of the special extract ERr 731® from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats

“…The study demonstrated that in the ERr 731 ® group, the Menopause Rating Scale II (MRS II) total score in addition to each of the 11 MRS II criteria representing cardinal symptoms of the climacteric were significantly reduced compared to the placebo group. Additionally, 82 subjects of this clinical trial continued intake of ERr 731 ® in the following 48-and 96-week open-label observational studies which demonstrated the longterm safety of ERr 731 ® , as no endometrial hyperplasia could be detected and no adverse events related to the study medication occurred [5]. However, in contrast to the clinical effectiveness of ERr 731 ® , little was known about the molecular mechanism of the extract or its potential metabolites.…”

Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats

“…In the present study we aimed to investigate the safety of a long-term dietary administration of ERr 731 ® as the extract has been administered as tablets in the clinical trials [9,[20][21][22]. Potential estrogenic effects on the uterine gene expression were tested after treatment of rats with two doses of ERr 731 ® over a 90-day period.…”

Complementary and Alternative Approaches to Menopause

“…Few adverse events were reported. 68 Recommendations Rhubarb should be regarded as possibly safe and possibly effective. There is limited evidence that applies to only one specific product, Estrovera.…”