Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats

Keiler, Annekathrin Martina; Papke, Anja; Kretzschmar, Georg; Zierau, Oliver; Vollmer, Günter

doi:10.1016/j.jsbmb.2011.08.016

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…The inflammatory-activated endothelial cells lose their anti-coagulant and modulatory properties in favor of pro-coagulant activity and pro-atherogenic effects. They also release numerous cytokines, chemokines, and growth factors, leading to an augmentation of the inflammatory response and an increase in endothelium permeability [ 11 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous rhubarb products are on the market as foods, dietary supplements, and alternative medicines. However, only the phytoestrogenic activity of R. rhaponticum has been well evidenced, including basic research, animal studies and clinical trials [ 8 , 9 , 10 , 11 ]. Other physiologically relevant activities (including the impact on components of the cardiovascular system) of this and other rhubarb species are only partly or even poorly recognized.…”

Section: Introductionmentioning

confidence: 99%

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Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response

et al. 2023

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Background: Inflammation, endothelial dysfunction, and alterations in blood physiology are key factors contributing to atherosclerosis and other cardiovascular disorders. Hence, modulation of endothelial function and reducing its pro-inflammatory and pro-thrombotic activity is considered one of the most important cardioprotective strategies. This study aimed to evaluate the anti-inflammatory potential of rhubarb extracts isolated from petioles and underground organs of Rheum rhabarbarum L. (garden rhubarb) and R. rhaponticum L. (rhapontic rhubarb) as well as two stilbenoids, typically found in these plants, i.e., rhapontigenin (RHPG) and its glycoside, rhaponticin (RHPT). Methods: Analysis of the anti-inflammatory effects of the indicated rhubarb-derived substances involved different aspects of the endothelial cells’ (HUVECs) response: release of the inflammatory mediators; cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX) expression as well as the recruitment of leukocytes to the activated HUVECs. The ability of the rhubarb-derived extracts to inhibit COX-2 and 5-LOX activities was examined as well. The study was supplemented with the in silico analysis of major components of the analyzed extracts’ interactions with COX-2 and 5-LOX. Results: The obtained results indicated that the examined plant extracts and stilbenes possess anti-inflammatory properties and influence the inflammatory response of endothelial cells. Biochemical and in silico tests revealed significant inhibition of COX-2, with special importance of rhaponticin, as a compound abundant in both plant species. In addition to the reduction in COX-2 gene expression and enzyme activity, a decrease in the cytokine level and leukocyte influx was observed. Biochemical tests and computational analyses indicate that some components of rhubarb extracts may act as COX-2 inhibitors, with marginal inhibitory effect on 5-LOX.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response

et al. 2023

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“…We suspected that substances in the extracts that similar to tamoxifen could stimulate osteoblastogenesis and increase bone density. [ 6 ] Tamoxifen contains a stilbene group which believes that it has selectivity when the acts on ERs.…”

Section: Discussionmentioning

confidence: 99%

“…In 1993, dry extract of rhubarb ( Rheum rhaponticum L.; Dahuang) was first used to treat symptoms of menopause. [ 6 ] Rheum root dry extract mainly contains rhaponticin which has a stilbene backbone. [ 7 ] Tamoxifen and other SERMS derivate compounds have stilbene's backbone.…”

Section: Introductionmentioning

confidence: 99%

Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat

Bahtiar

Setyowati

Mahanani

et al. 2021

J Adv Pharm Technol Res

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A BSTRACT Postmenopausal women have decreased levels of the hormone estrogen. Reduced estrogen levels will often involve many symptoms that reduced quality of life. This research aims to analyze the effects of Rheum officinale root extract on postmenopausal model rats. To this end, thirty rats underwent ovariectomy (OVX) surgery and six rats were operated without having their ovaries removed. The OVX was confirmed by body weight–uterus weight ratio and a vaginal swab. Six groups of the rats were performed: SHAM group and negative control groups are given vehicle; the positive control was assigned tamoxifen; and the extract has been given three doses 7, 35, and 175 mg/200 g BW, respectively, for 30 days. The calcium content of bone ash was measured using atomic absorption spectrophotometer. Blood pressure was evaluated using CODA ® , and the metabolites in the blood were assessed using gas chromatography–mass spectrometry (MS) and high-performance liquid chromatography. As a result, using ultra-performance liquid chromatography (UPLC)-MS, we found that the extract's major component was rhaponticin and its metabolites. The bone calcium levels increased with increasing doses of the extract. In the OVX group, the bone calcium content was decreased significantly 51.56% ± 8.9% g compared with the SHAM group 62.97% ±5.6% g, and the administration of Rheum extract could restore the calcium content of the bone to become 69.27% ± 3.8% g. From the above data, we concluded that Rheum root extracts contain astrigin, rhaponticin, rhapontigenin, and desoxyrhaponticin. Rheum root extract could improve calcium content and lipid profiles of OVX rats by stimulation osteoblastogenesis. Rheum root extracts could control the blood pressure of OVX rats by reducing lipid profiles.

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“…Scientific and medical interest in herbal preparations with estrogenic effects are additionally enhanced by data suggesting a beneficial role of phytoestrogens in prophylaxis of different women diseases, including osteoporosis and breast cancer (Obi et al 2009). Since the phytochemical profile of R. rhaponticum contains substances with estrogenic activities, this plant has gained scientific attention as a source of natural medicines, useful in the therapy of menopausal complaints or other hormone-related disorders (Chang et al 2016;Hasper et al 2009;Heger et al 2006;Kaszkin-Bettag et al 2008a, b, 2009Keiler et al 2012;Möller et al 2007;Papke et al 2009;Vollmer et al 2010;Wober et al 2007). The most important studies on molecular mechanisms of its biological action, pharmacological relevance and safety were summarized in the Table 3.…”

Section: Menopausal Complaintsmentioning

confidence: 99%

Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential

Kołodziejczyk-Czepas

Liudvytska

2020

Phytochem Rev

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The Rheum genus (Polygonaceae) covers about 60 species of rhubarbs, including specimens with a long ethnomedicinal history in Asia, Europe and other regions of the world. The work reviews available literature (until March, 2020) on phytochemical profile, ethnomedicinal recommendations, biological activities, pharmacological uses and future prospects for therapeutic applications of Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb). Although the above species are well-known vegetables, scientific interest in these plants is a relatively new issue; most of evidence of their biological activities and therapeutic potential derives from the last 15 years. Rhubarbs contain numerous bioactive substances, belonging to diverse groups of phytochemicals, e.g. stilbenes, anthraquinones and flavonoids. The registered special extract of R. rhaponticum (ERr731®) is administered to alleviate the menopause-related complaints. Furthermore, both ethnomedicinal surveys and recent studies on bioactive substances from rhubarbs indicate that these plants may have significantly broader range of beneficial effects such as antioxidant, anti-inflammatory, antimicrobial and cardioprotective activities.

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Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats

Cited by 10 publications

References 28 publications

Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response

Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response

Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat

Rheum rhaponticum and Rheum rhabarbarum: a review of phytochemistry, biological activities and therapeutic potential

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