Long-term effects of intrauterine exposure to mono-n-butyl phthalate on the reproductive function of postnatal rats

Kai, H.; Shono, Toshiyuki; Tajiri, Tatsuro; Suita, Sachiyo

doi:10.1016/j.jpedsurg.2004.10.009

Cited by 17 publications

(15 citation statements)

References 23 publications

(29 reference statements)

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“…There are many reports showing its long-term toxic effects and tissue accumulation in animals. 15,[25][26][27] The toxic effects depend on dose, the age of the person, and the duration of exposure. 28 It has been shown that the toxic effects are much more during infancy, puberty, and pregnancy periods, and long-term small amounts of exposure can cause evident toxic effects.…”

Section: Discussionmentioning

confidence: 99%

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Plasma Phthalate Levels in Pubertal Gynecomastia

Durmaz¹,

Özmert²,

Erkekoğlu

et al. 2010

Pediatrics

117

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WHAT'S KNOWN ON THIS SUBJECT:Being an androgen antagonist and a possible estrogen agonist, several endocrinologic effects of DEHP have been demonstrated mostly in vitro and in animals. A limited number of studies have linked the endocrinologic effects of DEHP and its metabolite, MEHP, in humans. WHAT THIS STUDY ADDS:To our knowledge, this is the first study to define a possible effect of DEHP and MEHP in pubertal gynecomastia. The etiology of pubertal gynecomastia is attributed either to excessive estrogen, deficient androgen, increased aromatase enzyme activity, or a combination. abstract OBJECTIVE: Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases. PATIENTS AND METHODS:The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Dog ramacı Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation. RESULTS:Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P Ͻ .001) (DEHP, 4.66 Ϯ 1.58 and 3.09 Ϯ 0.90 g/mL, respectively [odds ratio: 2.77 (95% confidence interval: 1.48 -5.21)]; MEHP, 3.19 Ϯ 1.41 and 1.37 Ϯ 0.36 g/mL [odds ratio: 24.76 (95% confidence interval: 3.5-172.6)]). There was a statistically significant correlation between plasma DEHP and MEHP levels (r: 0.58; P Ͻ .001). In the pubertal gynecomastia group, no correlation could be determined between plasma DEHP and MEHP levels and any of the hormone levels.CONCLUSIONS: DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia. Pediatrics 2010;125:e122-e129

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Section: Discussionmentioning

confidence: 99%

“…18 Experimental animal models showed its affects on developmental stages. 25,[29][30][31] Although DEHP has been shown to have toxic effects for many systems, the most important effects after long-term …”

Section: Discussionmentioning

confidence: 99%

Plasma Phthalate Levels in Pubertal Gynecomastia

Durmaz¹,

Özmert²,

Erkekoğlu

et al. 2010

Pediatrics

117

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“…Previous studies have demonstrated that MBP exposure has an adverse effect on testicular descent and germ cell development in both prenatal and postnatal rats (Imajima et al, 1997;Shono et al, 2005). A prenatal short-time exposure to MBP induces a long-term effect on postnatal rats and impairs reproductive function in male offspring (Kai et al, 2005). In prenatal rats, MBP exposure could inhibit testosterone production and expression of insulin-like factor 3 so as to prevent testicular descent in the fetal testes .…”

Section: Introductionmentioning

confidence: 99%

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of <i>Sox9</i> and <i>Dazl </i>

Xiong

Zhang

et al. 2017

J. Toxicol. Sci.

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-Mono-butyl phthalate (MBP) has reproductive toxicity but the related mechanisms have not been fully elucidated in vivo. We exposed male Balb/c mice to MBP by gavage at doses of 0, 25, 50, 100, 200 mg/kg for 14 days, and then evaluated the testicular alterations at the histological and molecular levels. MBP reduced mouse sperm count along with sperm malformation and seminiferous tubule degeneration in a dose-dependent manner. MBP dosed at 200 mg/kg significantly increased reactive oxygen species and malondialdehyde content in mouse testes. High doses of MBP (200 mg/kg) also significantly reduced mRNA expressions of testis growth and function related genes (Sox9 and Dazl). Our findings suggest that oxidative stress and down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.

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“…Plastik matriksinden s›zmalar› nedeniyle t›bbi uygulamalarla temas edildi¤i gibi, toplumun fitalatlara temas› genellikle diyet yoluyla ve kozmetik bak›m ürünleri yoluyla olmaktad›r. Di (2-etilhekzil) fitalat (DEHP), en yayg›n kullan›lan fitalat türevidir ve örne¤in PVC-t›bbi malzemelerde %20-40 oran›nda DEHP bulunmaktad›r (1)(2)(3)(4). Di (2-etilhekzil) dahil fitalatlar, endokrin bozucu kimyasal maddeler olarak de¤erlendirilmektedir.…”

Section: Giriflunclassified

“…Özellikle çocuklar›n bu etkiye daha duyarl› oldu¤u bilinmektedir (1). Fitalatlar hayvan karsinojenleridir ve fötal ölüm, malformasyonlar, anti-androjenik etki, teratojenite ve özellikle laboratuvar hayvanlar›nda testiküler hasar ile üreme sistemi üzerinde di¤er toksik etkilere neden olabilirler (3,4). Fitalatlarla do¤um öncesi dönemde karfl›laflman›n erkek s›çanlar›n üreme sisteminin geliflimini olumsuz etkiledi¤i bildirilmifltir (5).…”

Section: Giriflunclassified

Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi

Erkekoğlu¹,

Giray²,

Derman³

2010

tpa

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F Fi it ta al la at t t te em ma as s› › i il le e p pl la az zm ma a a am mi il la az z v ve e l li ip pa az z d dü üz ze ey yl le er ri i a ar ra as s› ›n nd da ak ki i i il li ifl flk ki in ni in n p pu ub be er rt ta al l j ji in ne ek ko om ma as st ti i h ha as st ta al la ar r› ›n nd da a d de e¤ ¤e er rl le en nd di ir ri il lm me es si i E Ev va al lu ua at ti io on n o of f t th he e c co or rr re el la at ti io on n b be et tw we ee en n p pl la as sm ma a a am my yl la as se e a an nd d l li ip pa as se e l le ev ve el ls s a an nd d p ph ht th ha al la at te e e ex xp po os su ur re e i in n p pu ub be er rt ta al l g gy yn ne ec co om ma as st ti ia a p pa at ti ie en nt ts s P P› ›n na ar r E Er rk ke ek ko o¤ ¤l lu u, , B Be el lm ma a G Gi ir ra ay y* *, , E Er rd de em m D Du ur rm ma az z, , E El li if f Ö Öz zm me er rt t* ** *, , M Mu ur ra at t K K› ›z z› ›l lg gü ün n, , O Or rh ha an n D De er rm ma an n, , K Ka ad dr ri iy ye e Y Yu ur rd da ak kö ök k* * Ö Öz zg gü ün n A Ar ra afl flt t› ›r rm ma a O Or ri ig gi in na al l A Ar rt ti ic cl le e Ö Öz ze et t S Su um mm ma ar ry yAim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and α−amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas. Material and Method:The study group was composed of 40 pubertal gynecomastia patients. Plasma phthalate levels (Di(2-ethylhexyl)phthalate, DEHP and mono (2-ethylhexyl) phthalate, MEHP) were determined using HPLC. Plasma lipase and α−amylase levels were measured by using enzymatic colorimetric assay.Results: Plasma DEHP and MEHP levels in gynecomatia patients were higher than the control group significantly. Significant negative correlations existed between α−amylase and MEHP levels in gynecomastia (r=-0.388, p<0.05) and overall study groups (r=-0.353, p<0.05).Negative correlation between DEHP and α−amylase levels was found to be significant in overall study group (r=-0.323, p<0.05). Conclusions:The results suggest that phthalate exposure might cause significant decreases in α-amylase secretion. The inverse correlation observed might be explained by the PPARγ (peroxisome proliferator-activated receptor gamma)-activation of phthalates. (Turk Arch Ped 2010; 45: 366-70)

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Long-term effects of intrauterine exposure to mono-n-butyl phthalate on the reproductive function of postnatal rats

Cited by 17 publications

References 23 publications

Plasma Phthalate Levels in Pubertal Gynecomastia

Plasma Phthalate Levels in Pubertal Gynecomastia

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of <i>Sox9</i> and <i>Dazl </i>

Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi

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