Fitalat teması ile plazma amilaz ve lipaz düzeyleri arasındaki ilişkinin pubertal jinekomasti hastalarında değerlendirilmesi

Abstract

F Fi it ta al la at t t te em ma as s› › i il le e p pl la az zm ma a a am mi il la az z v ve e l li ip pa az z d dü üz ze ey yl le er ri i a ar ra as s› ›n nd da ak ki i i il li ifl flk ki in ni in n p pu ub be er rt ta al l j ji in ne ek ko om ma as st ti i h ha as st ta al la ar r› ›n nd da a d de e¤ ¤e er rl le en nd di ir ri il lm me es si i E Ev va al lu ua at ti io on n o of f t th he e c co or rr re el la at ti io on n b be et tw we ee en n p pl la as sm ma a a am my yl la as se e a an nd d l li ip pa as se e l le ev ve el ls s a an nd d p ph ht th ha al la at te e e ex xp po os su ur re e i in n p pu ub be er rt ta al l g gy yn ne ec co om ma as st ti ia a p pa at ti ie en nt ts s P P› ›n na ar r E Er rk ke ek ko o¤ ¤l lu u, , B Be el lm ma a G Gi ir ra ay y* *, , E Er rd de em m D Du ur rm ma az z, , E El li if f Ö Öz zm me er rt t* ** *, , M Mu ur ra at t K K› ›z z› ›l lg gü ün n, , O Or rh ha an n D De er rm ma an n, , K Ka ad dr ri iy ye e Y Yu ur rd da ak kö ök k* * Ö Öz zg gü ün n A Ar ra afl flt t› ›r rm ma a O Or ri ig gi in na al l A Ar rt ti ic cl le e Ö Öz ze et t S Su um mm ma ar ry yAim: The aim of this study was to determine the correlation between plasma phthalate and pancreatic lipase and α−amylase levels in pubertal gynecomastia patients with high plasma levels of di(2-ethylhexyl)phthalate (DEHP) and its metabolite mono (2-ethylhexyl) phthalate (MEHP) which are known endocrine disrupting chemicals and to evaluate the possible effects of phthtalates in pancreas. Material and Method:The study group was composed of 40 pubertal gynecomastia patients. Plasma phthalate levels (Di(2-ethylhexyl)phthalate, DEHP and mono (2-ethylhexyl) phthalate, MEHP) were determined using HPLC. Plasma lipase and α−amylase levels were measured by using enzymatic colorimetric assay.Results: Plasma DEHP and MEHP levels in gynecomatia patients were higher than the control group significantly. Significant negative correlations existed between α−amylase and MEHP levels in gynecomastia (r=-0.388, p<0.05) and overall study groups (r=-0.353, p<0.05).Negative correlation between DEHP and α−amylase levels was found to be significant in overall study group (r=-0.323, p<0.05). Conclusions:The results suggest that phthalate exposure might cause significant decreases in α-amylase secretion. The inverse correlation observed might be explained by the PPARγ (peroxisome proliferator-activated receptor gamma)-activation of phthalates. (Turk Arch Ped 2010; 45: 366-70)

Health Risks Posed by Use of Di-2-Ethylhexyl Phthalate (DEHP) in Medical Devices

“…DEHP , endokrin bozucu kimyasal madde olarak değerlendirilmektedir. Özellikle çocukların bu etkiye daha duyarlı olduğu bilinmektedir (11).…”