Long-term effect of periodontal surgery on oral health and metabolic control of diabetics

Pranckevičienė, Alma; Siudikienė, Jolanta; Ostrauskas, Rytas; Mačhiulskienė, Vita

doi:10.1007/s00784-016-1819-y

Cited by 8 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another meta-analysis, non-surgical periodontal treatment improved metabolic control in patients with periodontitis and diabetes [25]. Moreover, another recent study demonstrated that better oral hygiene improved periodontal health and metabolic control, which also confirms our findings [40].…”

Section: Discussionsupporting

confidence: 87%

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Bukleta¹,

Krasniqi²,

Beretta³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Bukleta¹,

Krasniqi²,

Beretta³

et al. 2018

biomedicalresearch

View full text Add to dashboard Cite

“…Since then, epidemiologic studies have been extensively performed to establish a functional association between periodontitis and a variety of systemic diseases, including atherosclerosis, metabolic syndrome, and diabetes (Kaur et al 2009; Timonen et al 2010; Lockhart et al 2012). These correlations are further supported by clinical studies showing modulation of observed risk factors after periodontal therapy or improvement of periodontitis accompanied by systemic disease control (Makiura et al 2008; Bokhari et al 2012; Pranckeviciene et al 2017). As compared with the progress in validating the correlation, the underlying molecular mechanisms remain poorly understood.…”

Section: Introductionmentioning

confidence: 60%

Periodontal Pathogens Modulate Lipid Flux via Fatty Acid Binding Protein 4

et al. 2019

View full text Add to dashboard Cite

A strong correlation between chronic periodontitis and systemic diseases (e.g., cardiovascular disease, metabolic disorders) has been suggested for several decades. However, the evidence supporting this correlation is restricted primarily to epidemiologic studies, with only a few experimental outcomes confirming such a correlation and providing information about the underlying molecular mechanisms. To reveal a correlation between periodontitis and systemic diseases as well as a relevant molecular pathway, we investigated the effects of Porphyromonas gingivalis and Fusobacterium nucleatum, which play roles in chronic periodontitis progression, on Raw264.7 and THP-1 macrophages. Infection with P. gingivalis or F. nucleatum significantly induced the expression of fatty acid binding protein 4 (FABP4), one of the most important adipokines that play a role in the progression of systemic diseases such as atherosclerosis and type 2 diabetes. Periodontal pathogen–induced FABP4 expression in macrophages promoted lipid uptake by these cells, as demonstrated by the diminished lipid accumulation in cells treated with an FABP4 inhibitor, BMS309403, or with knockdown of FABP4 expression. This periodontal pathogen–induced FABP4 expression was dependent on the JNK pathway, and JNK inhibition reduced lipid uptake by reducing FABP4 expression. Serum levels of antibodies against P. gingivalis correlated with serum FABP4 levels in humans, whereas no association occurred between F. nucleatum antibody titers and FABP4 levels. To our knowledge, this report is the first to experimentally demonstrate that periodontal pathogens stimulate lipid uptake in macrophages by modulating FABP4 expression. These findings strongly support the hypothesis that periodontitis may affect the progression of various systemic diseases.

show abstract

“… 40 However, 3–12 months after periodontal surgery, the HbA1c level decreased in T1DM patients, but not in T2DM patients as studied in Lithuania. 41 Simpson et al. collected the data of 35 studies with 3249 participants and found that periodontal treatment really reduces the HbA1c value 3–6 months after treatment in T2DM patients.…”

Section: The Association Between Periodontal Disease and Diabetes Mel...mentioning

confidence: 99%

Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases

Chung,

Lee,

Chien

et al. 2024

Journal of Dental Sciences

View full text Add to dashboard Cite

Long-term effect of periodontal surgery on oral health and metabolic control of diabetics

Cited by 8 publications

References 27 publications

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Periodontal Pathogens Modulate Lipid Flux via Fatty Acid Binding Protein 4

Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases

Contact Info

Product

Resources

About