Impact of combined non-surgical and surgical periodontal treatment in patients with type 2 diabetes mellitus-a preliminary report randomized clinical study

Baseline HbA1c Level Influences the Effect of Periodontal Therapy on Glycemic Control in People with Type 2 Diabetes and Periodontitis: A Systematic Review on Randomized Controlled Trails

“…After title and abstract selection, 30 publications were retained for full-text review. After full-text evaluation, a total of 23 RCTs [ 9 , 11 , 15 – 35 ] were included in the present study. Figure 1 shows the PRISMA diagram of the study selection process.…”

New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies

“…Infrared spectra were recorded on a Jasco FT/IR-6100, Fourier transform infrared spectrometer at the cm À1 scale using the KBr disc technique at the Central Services Laboratory, National Research Centre, Dokki, Cairo, Egypt. 1 H NMR and 13 C NMR spectra were obtained by using a JEOL AS-500 NMR spectrometer (with operating frequencies of 500 MHz for 1 H using TMS as an internal standard and 125 MHz for 13 C) at the Central Services Laboratory, National Research Centre, Dokki, Cairo, Egypt. Chemical shis (d) are reported in parts per million (ppm) and coupling constants (J) are reported in Hertz (Hz).…”

“…Furthermore, hydrazinolysis of the 6-sulfonyl chloride intermediate 5 was carried out by its treatment with hydrazine hydrate in ethanol to get the corresponding 6-sulfonohydrazide derivative 8, which in turn underwent nucleophilic substitution by its reaction with various acid chloride derivatives, namely, acetyl chloride, 2-chloroacetyl chloride and benzoyl chloride, as well as with different iso(thio)cyanates to accomplish the corresponding N-substituted-6-sulfonohydrazide and hydrazinecarbox(thio)amide derivatives 9a-c, 10a-h, respectively (Scheme 2). The structural identication of the new target compounds was performed by microanalytical and IR, 1 H NMR, 13 the previously reported method. 50 The obtained results are expressed as IC 50 (nM) and summarized in Table 1.…”

“…[5][6][7][8] Diabetes is usually involved with multiple complications, such as cardiovascular diseases, 9 retinopathy, 10 neuropathy, 11,12 dental and kidney diseases. 13,14 There are other complications of diabetes, including wound interference cure, 15 ketoacidosis, hyperosmolar coma, 16,17 as well as reduced immunity to pneumonia and inuenza. 18,19 Recently, it has been reported that type 2 diabetes is one of the most important diseases that results in a signicant increase of the risk for hospitalization and death in COVID-19 patients.…”

“…,13 C NMR (DMSO-d 6 , d ppm): 30.36 (2CH 3 ), 115.03, 116.28, 121.26, 124.37, 127.79, 132.71, 134.29, 140.05, 141.47, 143.82 (Ar-C), 155.65 (2C]O), MS, m/z (%): 424 [M + ] (34.82), analysis for C 16 H 16 N 4 O 6 S 2 (424.45), calcd% C, 45.28; H, 3.80; N, 13.20; S, 15.11, found: % C, 45.39; H, 3.73; N, 13.46; S, 15.34. Yield (83%), m.p.…”