Baseline HbA1c Level Influences the Effect of Periodontal Therapy on Glycemic Control in People with Type 2 Diabetes and Periodontitis: A Systematic Review on Randomized Controlled Trails

Chen, Yafei; Zhan, Qiang; Wu, Chenzhou; Yuan, Yihang; Chen, Wen; Yu, Fan-Yuan; Li, Yang; Li, Longjiang

doi:10.1007/s13300-021-01000-6

Cited by 36 publications

(37 citation statements)

References 40 publications

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“…The reason why improvement in glycemic control was not achieved in our study may be because the patients' blood glucose levels at baseline were already well controlled to begin with (average HbA1c level < 7%, according to the definition of American Diabetes Association [23]). Furthermore, a systematic review indicated that the effect of periodontal treatment on glycemic control was much more obvious in studies with a higher baseline HbA1c level than in those with a lower baseline HbA1c level [43]. Another previous study indicated that the effect of lowering glucose differs based on factors such as the intervention method, duration of diabetes, baseline glycemia and whether the patient had undergone previous therapy [44].…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcomes and Oral Health-Related Quality of Life after Periodontal Treatment with Community Health Worker Strategy in Patients with Type 2 Diabetes: A Randomized Controlled Study

Hsu

Chen

Lin

et al. 2021

IJERPH

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Interventions engaging community health workers (CHW) for diabetes management aim to improve diabetes care and self-management behaviors among patients. We evaluated the effects of nonsurgical periodontal treatment (NSPT) with the CHW strategy on oral self-care behaviors, periodontal status and oral health-related quality of life (OHQoL) in patients with type 2 diabetes mellitus (T2DM). The participants were randomly assigned to experimental (EG; n = 35) and control (CG; n = 33) groups. All participants received NSPT, whereas the patients in the EG also received one-on-one 30 min lessons from a CHW over 4 weeks. The EG exhibited greater improvement in the probing pocket depth (β = −0.2, effect size [ES] = 0.61) and clinical attachment level (β = −0.2, ES = 0.59) at 1-month follow-up than the CG did. The ES increased over the 1-, 3- and 6-month follow-ups, indicating an increase in OHQoL (ES = 0.19, 0.60, and 0.62, respectively) in the EG. The patients in the EG were more likely to change their oral self-care behaviors than patients in the CG were. The NSPT with CHW strategy had a positive effect on 1-month periodontal treatment outcomes, long-term OHQoL and oral self-care behaviors in patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Clinical Outcomes and Oral Health-Related Quality of Life after Periodontal Treatment with Community Health Worker Strategy in Patients with Type 2 Diabetes: A Randomized Controlled Study

Hsu

Chen

Lin

et al. 2021

IJERPH

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“…The slight significant continuous reduction in blood glucose level may possibly have resulted from resolution of serum inflammatory factors as well as a possible reduction of glucolipid metabolism and insulin resistance by mechanical periodontal therapy [ 51 ] or may have been due to the effect of curcumin in minimizing the increase in blood glucose level in STZ-induced diabetes rat models [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats

Mohammad

Ali

Sha

et al. 2022

BioMed Research International

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This study aimed to evaluate the effect of curcumin gel on antioxidant marker level in experimental induced diabetes and periodontitis (EDP) in rats. Adult Wistar rats were randomized into five groups (20 each): (1) EDP treated with scaling and root planing (SRP) + curcumin gel (CU), (2) EDP treated with CU, (3) EDP treated with SRP, (4) EDP without treatment, and (5) systemically healthy and without ligature (control). Each group was subdivided equally into 4 subgroups of 5 rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ), and periodontitis was induced by a ligature. Blood samples were collected by cardiac puncture at 0, 7, 14, and 21 days to assess oxidative stress of malondialdehyde (MDA) and antioxidant enzymes of glutathione peroxidase (GPx), catalase (CAT), and suproxidase dismutase (SOD) levels. The results showed a significant increase in serum MDA and antioxidant enzyme levels in the untreated EDP group compared to the control group ( p < 0.05 ). The adjuvant use of CU to SRP resulted in a significant reduction of MDA and CAT levels as compared to the SRP group ( p < 0.05 ); however, significant reduction of GPX and SOD levels can be found only at day 7. It can be concluded that the decreased level of antioxidant enzymes can be construed as a result of decreased oxidative stress by curcumin therapy.

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“…Intervention studies have shown that NSPT can decrease HbA1c levels in people with DM and its efficacy is greater in patients with higher baseline HbA1c levels [ 25 , 40 , 41 , 42 , 43 ]. However, most NSPT studies were of short duration (3–6 months) because NSPT could only be delayed for a short period of time in the untreated control group for ethical reasons.…”

Section: Bidirectional Relationship Between Periodontitis and Dmmentioning

confidence: 99%

Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis

et al. 2022

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Periodontitis and diabetes are two major global health problems despite their prevalence being significantly underreported and underestimated. Both epidemiological and intervention studies show a bidirectional relationship between periodontitis and diabetes. The hypothesis of a potential causal link between the two diseases is corroborated by recent studies in experimental animals that identified mechanisms whereby periodontitis and diabetes can adversely affect each other. Herein, we will review clinical data on the existence of a two-way relationship between periodontitis and diabetes and discuss possible mechanistic interactions in both directions, focusing in particular on new data highlighting the importance of the host response. Moreover, we will address the hypothesis that trained immunity may represent the unifying mechanism explaining the intertwined association between diabetes and periodontitis. Achieving a better mechanistic insight on clustering of infectious, inflammatory, and metabolic diseases may provide new therapeutic options to reduce the risk of diabetes and diabetes-associated comorbidities.

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Baseline HbA1c Level Influences the Effect of Periodontal Therapy on Glycemic Control in People with Type 2 Diabetes and Periodontitis: A Systematic Review on Randomized Controlled Trails

Cited by 36 publications

References 40 publications

Clinical Outcomes and Oral Health-Related Quality of Life after Periodontal Treatment with Community Health Worker Strategy in Patients with Type 2 Diabetes: A Randomized Controlled Study

Clinical Outcomes and Oral Health-Related Quality of Life after Periodontal Treatment with Community Health Worker Strategy in Patients with Type 2 Diabetes: A Randomized Controlled Study

Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats

Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis

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