Long-term continuous exposure to static magnetic field reduces popolysaccharide-induced cytotoxicity of fibroblasts

Abstract

Our results suggest that SMF stimulation inhibits LPS-induced cytotoxicity through reduction of proinflammatory cytokines and increase in anti-inflammatory cytokines of NIH-3T3 cells.

Moderate strength (0.23–0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells

“…Of the nine networks identified by microarray profiling, the selection of IL-6 for additional scrutiny was based on several factors. First, a recent report linked 0.4 T SMF exposure to increased IL-6 production in fibroblasts [34] and plausible membrane-based modes of activation IL-6 (e.g., through Ca 2+ or TLR4) exist. Furthermore, reports that SMF can promote differentiation [20] – coupled with the propensity of the hEBD LVEC line used in this study to display neural markers [24] together with reports that IL-6 promotes astrocytogenesis [35] – offered the possibility that cell-level responses (e.g., differentiation of the hEBD cells to astrocytes) could be observed in these experiments.…”

A static magnetic field attenuates lipopolysaccharide-induced neuro-inflammatory response via IL-6-mediated pathway

“…Salerno et al (1999) showed that exposure to a static magnetic field from a commercially available 0.5 T MRI unit induced modifications in the release of some interleukins in peripheral blood mononuclear cells. Lin et al (2008a) demonstrated that long-term SMF stimulation inhibits LPSinduced cytotoxicity through increased IL-6 production by fibroblasts, the response of which is similar to endotoxin tolerance. In an animal study, LPS-injected mice that had been pre-exposed to an SMF for 2 h exhibited significantly better survival and had greater IL-6 levels in their blood compared to the sham-exposed group.…”

Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure: A histopathologic study in mice

“…Survival of bacterial infection among patients with MOF is improved by shutting down or controlling the septic response using antiendotoxin therapy (Deitch 1992, Balk 2000, Nguyen et al 2006). Since previous reports indicate that exposure to SMF increases the plasma levels of IL-1ra (Lin et al 2008(Lin et al , 2009), (2014) also proposed that pretreatment with SMF reduced LPS-induced neurodegenerative processes by inhibiting reactive oxygen species-induced neural tissue and neural cell damage.…”

“…Th e sham-exposed mice and SMF exposed mice were separately placed inside two identical plastic animal cages measuring 14 ϫ 8 ϫ 8 cm, as in previous studies (Lin et al 2008, Shen et al 2014. Th e background static geomagnetic fi eld was 4.3 ϫ 10 Ϫ5 T. A pair of neodymium (Nd 2 Fe 14 B) magnets measuring 13 ϫ 7 ϫ 1 cm (Chief-Lion Enterprise Co., Tainan, Taiwan) were placed on the outer surfaces of both the top and bottom of the animal cage housing the SMF-exposed mice ( Figure 1).…”

“…Since then, numerous investigations have focused on the eff ects of continuous SMF on infl ammatory responses in animals and cytokine release by peripheral blood mononuclear cells (Markov 2007). Although modifi cations in the release of TNF-α and IL-1 were not detected after SMF treatment (Salerno et al 1999, Aldinucci et al 2003, SMF exposure increased the amount of IL-1ra, resulting in suppression of LPS-induced cytotoxicity in NIH-3T3 cells (Lin et al 2008). A study in mice also demonstrated that the outcome of LPS-induced sepsis could be improved by pre-exposing the mice to a 0.25 T SMF (Lin et al 2009).…”