Long-term cancer risk associated with lung nodules observed on low-dose screening CT scans

Pinsky, Paul F.; Gierada, David S.

doi:10.1016/j.lungcan.2019.11.017

Cited by 17 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have found that PN is closely related to the occurrence of lung cancer. 16 The variety between the PN group and the healthy control group was statistically significant in TRAP1, while there was no difference or no difference between MAD2 and MSA. Therefore, TRAP1 has potential value for early detection of PN and early prevention of lung cancer.…”

Section: Discussionmentioning

confidence: 84%

TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

Li¹,

Xu²,

Chen³

et al. 2021

JIR

View full text Add to dashboard Cite

Purpose To explore the clinical significance of tumor necrosis factor receptor-associated protein (TRAP1), mitotic arrest deficient 2 (mad2) and anti-nuclear mitotic spindle apparatus antibody (MSA) in the diagnosis of small cell lung cancer (SCLC). Patients and Methods Serum concentrations of TRAP1 and MSA were determined by enzyme-linked immunosorbent assay (ELISA), including SCLC group (Num.=86), non-small cell lung cancer (NSCLC) group (Num.=105), pulmonary nodules (PN) group (Num.=94), and 60 healthy subjects as control group (Num.=60). Whereas fluorescence quantitative PCR (qt-PCR) method was used to detect the expression of mad2. Results The expression of TRAP1 was low in SCLC and NSCLC compared with the other two groups, and was the lowest in SCLC, which was negatively correlated with the occurrence of the disease (P<0.05); the sensitivity and specificity of TRAP1 for SCLC were 75.29%, 93.33%, and the area under SCLC curve was 0.903; compared with the other three groups, the level of MSA was the highest in the SCLC, and the results were significantly different (P<0.05), while the area under the SCLC curve was 0.856, and the sensitivity and specificity were 62.78% and 95.24%, respectively. Mad2 is overexpressed in SCLC, but not in PN. The area under the SCLC curve is 0.835, and the sensitivity and specificity are 56.98% and 92.38%; TRAP1 levels are negatively correlated with SCLC tumor stage, the level of TRAP1 was significantly lower in stage III–IV than in stage I–II (P<0.05); combined analysis of TRAP1 and MAD2 and MSA showed that the sensitivity and specificity for SCLS were 95.35% and 99.05%, respectively. Conclusion TRAP1 is of great value in the early diagnosis of SCLC as well as differential diagnosis with NSCLC. TRAP1 combined with MAD2 and MSA improved the sensitivity and specificity and provided a new idea for the clinical diagnosis of SCLC.

show abstract

Section: Discussionmentioning

confidence: 84%

TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

Li¹,

Xu²,

Chen³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…Visual detection is more prone to detect nodules larger than 3-5 mm (23). Such nodule size could be deemed the prognostically-diagnostically relevant dimensional range at the first screening round (e.g., baseline) (15,(24)(25)(26). Otherwise, any screening round after baseline (e.g., incidence round) will need high sensitivity also for smaller nodules, which might represent the inception of minuscule LC to be characterized in the following months (15,27).…”

Section: Detectmentioning

confidence: 99%

Screen-detected solid nodules: from detection of nodule to structured reporting

Silva¹,

Milanese²,

Ledda³

et al. 2021

Transl Lung Cancer Res

View full text Add to dashboard Cite

Lung cancer screening (LCS) trials raised over 100,000 participants in the last two decades (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). This wealth of data witnessed the feasibility of early detection of lung cancer (LC) by low-dose computed tomography (LDCT) for reduction of LC mortality, enhancing the concept of high-risk profiling (12,13), gender variability (2,6), and post-test risk stratification (14). LDCT approach took over other potential methods for early detection of LC (e.g., chest radiography, sputum, electronic nose, etc.) because it grants detailed representation of lung parenchyma and notable sensitivity to findings potentially associated with early LC, mainly lung nodules.Lung nodule is the most frequent finding in LDCT for LCS, it is seen in over 70% of screening participants (11) Review Article on Lung Cancer Screening

show abstract

“…In addition, a long time exposure to a dusty environment without proper protection has been reported to impair lung function and cause GGNs 28 . Moreover, people who maintain smoking habits for a long time are more likely to cause GGNs 24,29 . The proportion of plastics produced and used in the current industrial civilization has increased year by year, leading to the existence of a large number of microplastics in the environment.…”

Section: Introductionmentioning

confidence: 99%

An emerging role of microplastics in the etiology of lung ground glass nodules

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

Pulmonary ground glass nodules (GGNs) have been increasingly identified in past decades and is becoming an important clinical dilemma in oncology. Meanwhile, humans persistently inhale microplastics which are dominant in the air. However, the retention of “non-self” microplastics in human lung and its correlation with pulmonary GGNs remains elusive. In this study, we firstly demonstrated the presence of microfibers and microplastics in human lung, with higher detection rates in GGNs in comparison to those in normal tissue. Moreover, both types and colors of microfibers in tumor were richer than those in normal tissues. Intriguingly, high risk of microfibers exposure predisposes the formation of pulmonary GGN. Further, increased roughness surface was observed in microfibers isolated in human lung, indicating the possible link of surface roughness to the formation of pulmonary GGN. Collectively, our findings reveal an emerging role of environmental microplastics exposure in the etiology of pulmonary GGN.One Sentence SummaryThe exposure of environmental microplastics is a risk factor of pulmonary GGN.

show abstract

Long-term cancer risk associated with lung nodules observed on low-dose screening CT scans

Cited by 17 publications

References 15 publications

TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

TRAP1 Shows Clinical Significance in the Early Diagnosis of Small Cell Lung Cancer

Screen-detected solid nodules: from detection of nodule to structured reporting

An emerging role of microplastics in the etiology of lung ground glass nodules

Contact Info

Product

Resources

About