Long-Term Benefit of Primary Angioplasty as Compared with Thrombolytic Therapy for Acute Myocardial Infarction

Zijlstra, Felix; Hoorntje, Jan C.A.; Boer, Menko Jan de; Reiffers, S.; Miedema, Kor; Ottervanger, Jan Paul; Hof, Arnoud W.J. van’t; Suryapranata, Harry

doi:10.1056/nejm199911043411901

Cited by 569 publications

(98 citation statements)

References 31 publications

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“…With the Danish Multicenter Randomized Study on Fibrinolytic Therapy versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) trial [24] that ended in 2001 all STEMI patients were recommended to be treated with primary PCI if transportation time to an invasive center is less than two hours. Prior to this study PCI was known to reduce mortality in STEMI patients [25], but the transportation time to an invasive facility was considered a major limitation on the widespread use of PCI performed immediately after the STEMI. It is evident to see that the increase in the number of PCI performed on days 0-1 after MI (Fig.…”

Section: Discussionmentioning

confidence: 99%

Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Gjesing¹,

Gislason²,

Køber³

et al. 2014

European Journal of Internal Medicine

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Section: Discussionmentioning

confidence: 99%

Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Gjesing¹,

Gislason²,

Køber³

et al. 2014

European Journal of Internal Medicine

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“…In the current study the possibility of differentiated impact of treatment on prognosis has been eliminated because all patients underwent an early invasive treatment that has been proved to improve survival in patients with STEMI [18], NSTEMI [13, 14] and unstable angina [4]. Moreover, the recently reported reductions in the 6-month rates of new heart failure and mortality in patients with ACS may be attributed, at least in part, to the progressive increase in the use of primary PCI in these patients [19].…”

Section: Discussionmentioning

confidence: 99%

Patterns of Presentation and Outcomes of Patients with Acute Coronary Syndromes

et al. 2009

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Objectives: We undertook this study to assess the relationship between presentation pattern and mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention. Methods: This registry included 10,455 patients with ACS, of whom 2,853 patients had ST-segment elevation myocardial infarction(STEMI), 3,060 patients had non-ST-segment elevation myocardial infarction (NSTEMI) and 4,542 patients had unstable angina. The primary outcome was 1-year mortality. Results: At 1 year there were 976 deaths, 390 (13.7%) among STEMI patients, 366 (12.0%) among NSTEMI patients and 220 (4.8%) among patients with unstable angina (OR = 1.17, 95% CI 1.01–1.35 for STEMI vs. NSTEMI; OR = 3.00, 95% CI 2.56–3.51 for STEMI vs. unstable angina, and OR = 2.58, 95% CI 2.20–3.04 for NSTEMI vs. unstable angina). In the Cox proportional hazards model ACS form was an independent correlate of 1-year mortality (HR = 0.90, 95% CI 0.73–1.13 for STEMI vs. NSTEMI; HR = 1.56, 95% CI 1.13–2.14 for STEMI vs. unstable angina; HR = 1.72, 95% CI 1.30–2.29 for NSTEMI vs. unstable angina). Conclusions: The presentation pattern affects 1-year mortality in patients with ACS, with unadjusted mortality being highest in patients with STEMI and lowest in patients with unstable angina.

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“…Primary PCI has in several studies been shown to be superior to fibrinolytic therapy with regard to recurrent ischemia, reinfarction and mortality [21, 22, 23], and in a recent study it was documented that primary PCI is superior to fibrinolysis also with regard to myocardial salvage and final infarct size [24]. Despite a primary PCI procedure, there are still patients, who have larger infarctions and severely impaired LV function, and in whom there is a higher risk of LV remodeling with LV dilation.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

Kaltoft

Bøttcher²,

Sand³

et al. 2003

Cardiology

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Following an acute myocardial infarction, the size of the infarct and the resulting left ventricular volume and function are important predictors of mortality. Identifying patients with impaired tissue level perfusion after percutaneous coronary intervention (PCI) for myocardial infarction therefore could have prognostic implications. To obtain combined measures of left ventricular perfusion, volumes and function we applied a gated myocardial perfusion imaging by ^99mTc-sestamibi single photon emission computerized tomography to 19 patients immediately after revascularization by PCI and repeated this after 3 months. The results of the acute myocardial perfusion imaging significantly correlated to final infarct size, left ventricular volumes and function 3 months later. It is concluded that the method holds the potential for risk stratifying patients immediately after revascularization for acute myocardial infarction.

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Long-Term Benefit of Primary Angioplasty as Compared with Thrombolytic Therapy for Acute Myocardial Infarction

Cited by 569 publications

References 31 publications

Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Patterns of Presentation and Outcomes of Patients with Acute Coronary Syndromes

Electrocardiographic Gated <sup>99m</sup>Tc-Sestamibi SPECT Immediately after Primary Percutaneous Coronary Intervention Characterizes Reperfusion Success

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