Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Gjesing, Anne; Gislason, Gunnar; Køber, Lars; Smith, J Gustav; Christensen, Stefan; Gustafsson, Finn; Olsen, Anne-Marie Schjerning; Torp‐Pedersen, Christian; Andersson, Charlotte

doi:10.1016/j.ejim.2014.08.009

Cited by 34 publications

(32 citation statements)

References 36 publications

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“…There was a trend towards admission of patients greater than 65 years of age that is in line with all recent studies that found a shift in diagnosis of PH to an older age [13,[18][19][20]. Most patients continued to be women in both 2000 and 2013.…”

Section: Age Characteristics and Payer Statussupporting

confidence: 75%

Nationwide Trends in Inpatient Admissions of Pulmonary Hypertension in the United States from 2000 to 2013

Sikachi

Sahni

Mehta

et al. 2017

Advances in Respiratory Medicine

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Introduction: Pulmonary Hypertension (PH) is a disorder of the pulmonary vasculature with high mortality and bears a large economic burden on the healthcare system. We conducted a review of the largest inpatient database in the United States and analyzed the trends in hospitalizations due to PH from the turn of the century (2000) to 2013 to evaluate the rate of hospitalizations and determine the cost and mortality associated with PH. Conclusion:The number of inpatient discharges related to PH has increased even though the number of inpatient discharges with PAH has been reported to be lower in literature. The mean length of stay has also shown a mild increase. This increase is associated with a significant increase in the mean and aggregate cost. These inpatient costs associated with PH contribute significantly to the total healthcare burden. Further research on cost-effective evaluation and management of PH is required.

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Section: Age Characteristics and Payer Statussupporting

confidence: 75%

Nationwide Trends in Inpatient Admissions of Pulmonary Hypertension in the United States from 2000 to 2013

Sikachi

Sahni

Mehta

et al. 2017

Advances in Respiratory Medicine

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“…6 However, during the last decades, a significant decrease in the incidence of and an improvement in the outcome of several major cardiovascular diseases, including HF and acute myocardial infarction (AMI), have been observed in several countries. [7][8][9][10][11][12][13] This can be attributed in part to the widespread implementation of effective therapies such as angiotensin-converting enzyme (ACE) inhibitors, β-blockers, statins, and coronary interventions, as well as lifestyle improvements, including decreased smoking rates.…”

Section: Editorial See P 969 Clinical Perspective On P 994mentioning

confidence: 99%

Temporal Trends in the Incidence and Prognosis of Aortic Stenosis

Martinsson

Andersson

et al. 2015

Circulation

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Background-The aging of Western populations is expected to result in increasing occurrence of aortic stenosis (AS), but data are limited. Recent studies have reported declining incidence and mortality for other major heart diseases. We aimed to study temporal trends in the incidence and prognosis for AS in Sweden. Methods and Results-With the use of nationwide registers, all adult patients in the Swedish population with a first diagnosis of AS, heart failure, acute myocardial infarction, and aortic valve replacement for AS between 1989 and 2009 were identified and followed up until the end of 2010 for all-cause and cardiovascular-related mortality. The age-adjusted incidence of AS in Sweden declined from 15.0 to 11.4 in men and 9.8 to 7.1 in women per 100 000 between 1989 to 1991 and 2007 to 2009, and the median age at diagnosis increased by 4 years for both men and women. The age-and sexadjusted relative risk of 1-and 3-year mortality in 2007 to 2009 was 0.58 (95% confidence interval, 0.53-0.63) and 0.60 (95% confidence interval, 0.56-0.65), respectively, compared with 1989 to 1991. Similar improvements were observed for heart failure and acute myocardial infarction. Findings were broadly consistent across subgroups. Postoperative mortality at 30 days declined despite increased median age at diagnosis. Conclusions-Incidence and mortality rates in AS in Sweden declined between 1989 and 2009 to an extent similar to that observed for heart failure and acute myocardial infarction. These findings could suggest that improved risk factor control and cardiovascular therapy, combined with increased use of aortic valve replacement in the elderly and reduced perioperative mortality in aortic valve replacement, have translated into favorable effects for AS.

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“…In recent decades, major advances in prevention and treatment have led to dramatic decline in morbidity and mortality rates following MI [3, 4]. In spite of these advances in both the early management and longer-term treatment, MI was still a major cause of disability worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7

Yuan

Chen

et al. 2017

Cell Physiol Biochem

191

140

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Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as an important factor in the deterioration of heart function. Previous studies have demonstrated that miR-21 plays an important role in various pathophysiological processes in the heart. However, the role of miR-21 in fibrosis regulation after MI remains unclear. Methods: To induce cardiac infarction, the left anterior descending coronary artery was permanently ligated of mice. First, we explored the expression of miR-21 in the infarcted zone in mice model of MI via RT-qPCR. Next, we examined the effects of TGF-β1 on miR-21 expression in cardiac fibroblasts (CFs). Then, CFs were infected with miR-21 mimics or miR-21 inhibitors to investigate the effects of miR-21 on the process of CFs activation in vitro. Further, bioinformatics analysis and luciferase reporter assay were performed to identify and validate the target gene of miR-21. At last, in-vivo study was done to confirm MiR-21 regulated myocardial fibrosis after MI in mice. Results: MiR-21 was up-regulated in the infarcted zone after MI in vivo. TGF-β1 treatment increased miR-21 expression in CFs. Overexpression of miR-21 promoted the effects of TGF-β1-induced activation of CFs, evidenced by increased expression of Col-1, α-SMA and F-actin, whereas inhibition of miR-21 attenuated the process of fibrosis. Bioinformatics, Western blot analysis and luciferase reporter assay demonstrated that Smad7 is a direct target of miR-21. In addition, in-vivo study revealed that MiR-21 regulated myocardial fibrosis after MI in mice. Conclusion: These findings suggested that miR-21 has a critical role in CF activation and cardiac fibrosis after MI through via TGF-β/Smad7 signaling pathway. Thus, miR-21 promises to be a potential therapy in treatment of cardiac fibrosis after MI.

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Nationwide trends in development of heart failure and mortality after first-time myocardial infarction 1997–2010: A Danish cohort study

Cited by 34 publications

References 36 publications

Nationwide Trends in Inpatient Admissions of Pulmonary Hypertension in the United States from 2000 to 2013

Nationwide Trends in Inpatient Admissions of Pulmonary Hypertension in the United States from 2000 to 2013

Temporal Trends in the Incidence and Prognosis of Aortic Stenosis

Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7

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