Long noncoding RNA TFAP2A‐AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR‐1297 and regulating TFAP2A expression

Yang, Kaicheng; Niu, Yue; Cui, Zifeng; Jin, Lin‐Yu; Peng, Shixiong; Zhang, Dong

doi:10.1002/mc.23438

Cited by 6 publications

(7 citation statements)

References 43 publications

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“…Upregulation of TFAP2A has been observed in lung adenocarcinoma and is involved in increased EMT in in vivo and in vitro, as well as increased metastasis of LUAD 22 . In a previous study, we found that TFAP2A can promote the growth of OSCC cells, their transition from epithelial to mesenchymal cells, and their migration and invasion 14 . However, the mechanisms through which TFAP2A affects OSCC development and the molecules with which it interacts are not currently understood.…”

Section: Discussionmentioning

confidence: 92%

“…It has been suggested that TFAP2A regulates tectonic 1′s involvement in OSCC, which enhances the invasion, migration, and proliferation of OSCC CAL27 and SCC15 cells 13 . According to our previous study, we found that TFAP2A can promote cell growth, epithelial–mesenchymal transition (EMT), and migration/invasion in OSCC 14 . The target of TFAP2A was, however, not clear in OSCC.…”

Section: Introductionmentioning

confidence: 85%

“…22 In a previous study, we found that TFAP2A can promote the growth of OSCC cells, their transition from epithelial to mesenchymal cells, and their migration and invasion. 14 In addition, TFAP2A is discovered to be a transcription factor of the hub genes. 26 Zhang et al 27 found that RELA and TFAP2A are transcription factors connected to cerebral ischemia-reperfusion injury, which are mostly involved in pathways having to do with inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…13 According to our previous study, we found that TFAP2A can promote cell growth, epithelial-mesenchymal transition (EMT), and migration/invasion in OSCC. 14 The target of TFAP2A was, however, not clear in OSCC.…”

Section: Introductionmentioning

confidence: 99%

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RELA promotes the progression of oral squamous cell carcinoma via TFAP2A‐Wnt/β‐catenin signaling

Yang

Zhao

Liu

et al. 2023

Molecular Carcinogenesis

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Oral squamous cell carcinoma (OSCC) has emerged as the most prevailing oral malignancy worldwide, characterized by cervical solid lymph node metastasis and strong local invasiveness. Overexpression of Transcription Factor AP-2 alpha (TFAP2A) is observed in a significant proportion of OSCC cases. In this study, we aimed to elucidate the function of TFAP2A in the progression of OSCC and the related molecular signaling pathways. The role of RELA was predicted using bioinformatics analysis. The mRNA abundances of RELA, TFAP2A, and β-catenin were assessed by Western blot and quantitative real-timePCR. The relationship between RELA, TFAP2A, and β-catenin and their correlation with clinicopathological characteristics of OSCC was evaluated. The target of RELA and TFAP2A was identified by the chromatin immunoprecipitation as well as luciferase reporter assay. The colony formation assay and MTS assay were performed to determine the proliferative level of OSCC cells. OSCC cell motility was determined by Transwell assay and wound-healing assay. The protein expressions of epithelial-mesenchymal transition-associated factors were evaluated by Western blot. The expressions of RELA and TFAP2A were elevated in OSCC, and their expressions displayed a positive correlation. The expression levels of RELA and TFAP2A were found to be associated with TNM staging and lymphatic metastasis of OSCC patients. RELA upregulation promoted OSCC progression, as manifested by increased levels of proliferation, invasion, and migration of OSCC cells. We also demonstrated that RELA was directly bound to the promoter of TFAP2A transcription, which activated multiple malignant and metastatic phenotypes.Furthermore, TFAP2A activated the Wnt/β-catenin signaling by targeting the promoter regions of β-catenin. The study found that RELA is critical for promoting the progression of OSCC via the RELA-TFAP2A-Wnt/β-catenin signaling pathway.The RELA-TFAP2A-Wnt/β-catenin signaling pathway is a potential target for reducing the aggressiveness of OSCC.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

RELA promotes the progression of oral squamous cell carcinoma via TFAP2A‐Wnt/β‐catenin signaling

Yang

Zhao

Liu

et al. 2023

Molecular Carcinogenesis

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“…For example, Linc00467 can regulate miR-1285-3p/TFAP2A expression, thereby facilitating the invasion of head and neck squamous cell carcinoma cells and inhibiting apoptosis ( 13 ). Long-stranded non-coding RNA TFAP2A-AS1 produces oncogenic effects in oral squamous cell carcinoma by regulating the miR-1297/TFAP2A axis ( 34 ). miR-876-5p inhibits breast cancer progression by regulating cell proliferation, migration and invasion in a TFAP2A-dependent manner ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1

et al. 2023

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Transcription factor AP-2 alpha (TFAP2A) is a critical cell growth regulator that is overexpressed in various tumor tissues. However, its role in the development of cervical cancer remains unknown. In the present study, public databases were thus explored and a higher expression of TFAP2A was found in cervical cancer. A total of 131 clinical samples were collected and it was also identified that TFAP2A was highly expressed in cervical tumor tissues. TFAP2A was also found to be associated with a higher tumor stage, lymph node metastasis and a poor patient survival. In vitro experiments revealed that the knockdown of TFAP2A inhibited the proliferation and migration of cervical cancer cells and promoted apoptosis. Furthermore, it was observed that TFAP2A could bind the programmed death-ligand 1 (PD-L1) promoter region and PD-L1 rescued TFAP2A expression. In vivo experiments also revealed that TFAP2A promoted tumor growth. Collectively, in the present study it was demonstrated that TFAP2A is a transcription factor of PD-L1 and a prognostic factor with clinical value, identifying a positive feedback loop of TFAP2A/PD-L1.

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Construction and Validation of a Seven Anoikis-Related lncRNA Risk Model for Breast Cancer

Lin,

Li,

Shen

et al. 2023

Indian J Surg

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Long noncoding RNA TFAP2A‐AS1 promotes oral squamous cell carcinoma cell growth and movement via competitively binding miR‐1297 and regulating TFAP2A expression

Cited by 6 publications

References 43 publications

RELA promotes the progression of oral squamous cell carcinoma via TFAP2A‐Wnt/β‐catenin signaling

RELA promotes the progression of oral squamous cell carcinoma via TFAP2A‐Wnt/β‐catenin signaling

TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1

Construction and Validation of a Seven Anoikis-Related lncRNA Risk Model for Breast Cancer

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