TFAP2A promotes cervical cancer via a positive feedback pathway with PD‑L1

Abstract

Transcription factor AP-2 alpha (TFAP2A) is a critical cell growth regulator that is overexpressed in various tumor tissues. However, its role in the development of cervical cancer remains unknown. In the present study, public databases were thus explored and a higher expression of TFAP2A was found in cervical cancer. A total of 131 clinical samples were collected and it was also identified that TFAP2A was highly expressed in cervical tumor tissues. TFAP2A was also found to be associated with a higher tumor stage, lymph node metastasis and a poor patient survival. In vitro experiments revealed that the knockdown of TFAP2A inhibited the proliferation and migration of cervical cancer cells and promoted apoptosis. Furthermore, it was observed that TFAP2A could bind the programmed death-ligand 1 (PD-L1) promoter region and PD-L1 rescued TFAP2A expression. In vivo experiments also revealed that TFAP2A promoted tumor growth. Collectively, in the present study it was demonstrated that TFAP2A is a transcription factor of PD-L1 and a prognostic factor with clinical value, identifying a positive feedback loop of TFAP2A/PD-L1.

An Integrated Data Analysis Using Bioinformatics and Random Forest to Predict Prognosis of Patients With Squamous Cell Lung Cancer

“…PLXNB3 is associated with progression, mortality, and lung metastasis in breast cancer [77]. TFAP2A is a critical cell growth regulator that is overexpressed in various tumor tissues [78] and is considered a prognostic marker in lung cancer [66], and VIL1 is a gene associated with the cytoskeleton. Another gene that stood out was GCGR, which showed high expression in the primary tumor when compared to normal tissues.…”