Long Non-Coding RNAs Involved in Cancer Development and Cell Fate Determination

Kitagawa, Masatoshi; Kotake, Yojiro; Ohhata, Tatsuya

doi:10.2174/138945012803530026

Cited by 59 publications

(39 citation statements)

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“…[20][21][22] This group of RNAs modulates gene expression through multiple mechanisms, such as epigenetics, alternative splicing, small RNA sponging as well as transcriptional and translational regulation. [23][24][25][26] Accumulating studies have shown that lncRNAs are involved in the regulation of autoimmunity-and inflammation-related processes, including nuclear factor-κB and Toll-like receptor signalling, cytokine expression, and immune cell proliferation and differentiation.…”

Section: -16mentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-κB signalling and T-cell response pertinent to autoimmunity and inflammation. Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful.

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Section: -16mentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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“…LncRNA is defined as a non-protein-coding RNA molecule longer than 200 nucleotides in length (7,8). In past decades, these long non-coding transcripts were simply considered as transcriptional 'noise' or cloning artifacts (9).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

2015

Oncology Letters

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Abstract. The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as significant protagonists of cellular functions. The dysregulation of lncRNAs has increasingly been linked to numerous human diseases, particularly cancers. Recent studies have demonstrated that the lncRNA growth arrest-specific transcript 5 (GAS5) was pervasively downexpressed in most human cancers compared with non-cancerous adjacent tissues including gastric, breast, lung and prostate cancer. In addition, patients with decreased GAS5 expression have a significantly poorer prognosis than those with higher expression. Furthermore, GAS5 is involved in the control of cell apoptosis, proliferation, metastasis, angiogenesis, DNA repair and tumor cell metabolism. This review provides an overview of the current knowledge concerning the role of GAS5 in tumor expression and biology function.

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“…NF-Y directly binds to and activates the promoter of the pro-apoptotic gene, FAS cell surface death receptor (FAS) (13). Most lncRNAs involved in transcriptional regulation function as recruiters for transcriptional regulators such as polycomb proteins (14,15). However, PANDA does not function as a recruiter but as a repressor of NF-YA.…”

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confidence: 99%