Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

Yu, Xuezhong; Li, Zheng

doi:10.3892/ol.2015.3553

Cited by 73 publications

(58 citation statements)

References 51 publications

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“…28,29 Many studies demonstrated that lncRNAs Relative ratio of invasive cells per field is shown. *P < .05, **P < .01 and ***P < .001…”

Section: Discussionmentioning

confidence: 99%

Downregulation of lncRNA CASC2 facilitates osteosarcoma growth and invasion through miR‐181a

Hao

et al. 2017

Cell Proliferation

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Objectives: Long non-coding RNA cancer susceptibility candidate 2 (CASC2) is a novel lncRNA and has been indicated as playing tumour suppressor gene in several tumours.However, the role of CASC2 in osteosarcoma is still uncovered. Materials and methods:The CASC2 and miR-181a expressions were measured via qRT-PCR. CCK-8 assay and colony formation assay were performed to determine the cell growth, and transwell assay was performed to assess the cell invasion. Results:We showed that CASC2 expression was downregulated in osteosarcoma samples and cell lines. Moreover, we showed that downregulated expression of CASC2 was correlated with advanced TNM stage. Furthermore, overexpression of CASC2 inhibited osteosarcoma cell proliferation, colony formation, and invasion. In addition, we indicated that ectopic expression of CASC2 suppressed miR-181a expression and enhanced the expression of Ras association domain family member 6 (RASSF6), PTEN and ATM in osteosarcoma cell, which were the direct target gene of miR-181a. Moreover, we indicated that RASSF6 expression was downregulated in osteosarcoma samples and cell lines and downregulated expression of RASSF6 was correlated with advanced TNM stage. We found that the expression of RASSF6 was positively correlated with the expression of CASC2 in osteosarcoma tissues. Ectopic expression of CASC2 suppressed the osteosarcoma cell proliferation, colony formation and invasion through regulating RASSF6 expression. Conclusions:Our data illuminated that CASC2 acted as a tumour suppressor in osteosarcoma progression.

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“…28,29 Many studies demonstrated that lncRNAs Relative ratio of invasive cells per field is shown. *P < .05, **P < .01 and ***P < .001…”

Section: Discussionmentioning

confidence: 99%

Downregulation of lncRNA CASC2 facilitates osteosarcoma growth and invasion through miR‐181a

Hao

et al. 2017

Cell Proliferation

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“…[20][21][22] This group of RNAs modulates gene expression through multiple mechanisms, such as epigenetics, alternative splicing, small RNA sponging as well as transcriptional and translational regulation. [23][24][25][26] Accumulating studies have shown that lncRNAs are involved in the regulation of autoimmunity-and inflammation-related processes, including nuclear factor-κB and Toll-like receptor signalling, cytokine expression, and immune cell proliferation and differentiation.…”

Section: -16mentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-κB signalling and T-cell response pertinent to autoimmunity and inflammation. Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful.

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“…[17–20]. Increasing evidences show that lncRNAs play a critical role in the cell biology such as cell proliferation, metabolism, differentiation, development, invasion, migration and apoptosis [21–25].…”

Section: Introductionmentioning

confidence: 99%

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

Meng

Ren

et al. 2016

PLoS ONE

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Accumulating studies have demonstrated that long noncoding RNAs (lncRNAs) act a crucial role in the development of tumors. However, the role of lncRNAs in lung cancer remains largely unknown. In this study, we demonstrated that theexpression of RMRP was upregulated in lung adenocarcinoma tissues compared to the matched adjacent normal tissues. Moreover, of 35 lung adenocarcinoma samples, RMRP expression was upregulated in 25 cases (25/35; 71.4%) compared to the adjacent normal tissues. We also showed that RMRP expression was upregulated in lung adenocarcinoma cell lines (A549, SPC-A1, H1299 and H23) compared to the bronchial epithelial cell line (16HBE). Ectopic expression of RMRP promoted lung adenocarcinoma cell proliferation, colony formation and invasion. In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration. Our data proved that RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer. These data suggested that RMRP might serve as a therapeutic target in lung adenocarcinoma.

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Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

Cited by 73 publications

References 51 publications

Downregulation of lncRNA CASC2 facilitates osteosarcoma growth and invasion through miR‐181a

Downregulation of lncRNA CASC2 facilitates osteosarcoma growth and invasion through miR‐181a

Long non‐coding RNAs in rheumatoid arthritis

LncRNA-RMRP Acts as an Oncogene in Lung Cancer

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