Long non-coding RNAs in cancer progression

Tano, Keiko; Akimitsu, Nobuyoshi

doi:10.3389/fgene.2012.00219

Cited by 210 publications

(156 citation statements)

References 49 publications

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“…[20][21][22] This group of RNAs modulates gene expression through multiple mechanisms, such as epigenetics, alternative splicing, small RNA sponging as well as transcriptional and translational regulation. [23][24][25][26] Accumulating studies have shown that lncRNAs are involved in the regulation of autoimmunity-and inflammation-related processes, including nuclear factor-κB and Toll-like receptor signalling, cytokine expression, and immune cell proliferation and differentiation.…”

Section: -16mentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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Rheumatoid arthritis, a disabling autoimmune disease, is associated with altered gene expression in circulating immune cells and synovial tissues. Accumulating evidence has suggested that long non-coding RNAs (lncRNAs), which modulate gene expression through multiple mechanisms, are important molecules involved in immune and inflammatory pathways. Importantly, many studies have reported that lncRNAs can be utilized as biomarkers for disease diagnosis and prognostication. Recently, dysregulation of lncRNAs in rheumatoid arthritis and other autoimmune diseases has been revealed. Experimental studies also confirmed their crosstalk with matrix metalloproteinases, nuclear factor-κB signalling and T-cell response pertinent to autoimmunity and inflammation. Circulating lncRNAs, such as HOTAIR, differentiated patients with rheumatoid arthritis from healthy subjects. Taken together, lncRNAs are good candidates as biomarkers and therapeutic targets in rheumatoid arthritis. Further investigation on in vivo delivery of these regulatory molecules and large-cohort validation of their clinical applicability may be useful.

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Section: -16mentioning

confidence: 99%

Long non‐coding RNAs in rheumatoid arthritis

Zheng

Jiang

et al. 2017

Cell Proliferation

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“…The antisense non-coding RNA in the INK4 locus (ANRIL) is a recently discovered lncRNA encoded in the chromosome 9p21 region, which has been highlighted as a hotspot for cancer research because this gene locus is often homozygously deleted or transcriptionally silenced in ~40% of human cancers (16). The data gathered to date strongly implicate ANRIL in the epigenetic regulation of INK4b/ARF/ INK4a tumour suppressors (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer

Qiu

Lin

Ding

et al. 2015

International Journal of Oncology

120

103

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Abstract. Recent studies have highlighted the role of long non-coding RNAs (lncRNAs) in carcinogenesis and have suggested that genes of this class might be used as biomarkers in cancer. However, whether lncRNAs are involved in serous ovarian cancer (SOC) remains largely unknown. In the present study, we focused on lncRNA antisense non-coding RNA in the INK4 locus (ANRIL) and investigated its expression pattern, clinical significance, and biological function in SOC. We found that ANRIL levels were elevated in SOC tissues compared with normal controls and were highly correlated with advanced FIGO stage, high histological grade, lymph node metastasis, and poor prognosis. Multivariate analysis further revealed that ANRIL is an independent prognostic factor for predicting overall survival of SOC patients. In vitro, we compared differential ANRIL levels between SOC parental cell lines (SK-OV-3, HO8910) and highly metastatic sublines (SK-OV-3.ip1, HO8910-PM). Notably, ANRIL was highly expressed in both SK-OV-3.ip1 cells and HO8910-PM cells. SiRNA-mediated ANRIL silencing in these cells impaired cell migration and invasion. Based on the metastasis-related mRNA microarray analysis and subsequent western blotting confirmation, we found that MET and MMP3 are key downstream genes of ANRIL involved in SOC cell migration/ invasion. Together, our data suggest that lncRNA ANRIL plays an important role in SOC invasion/metastasis and could represent a novel biomarker for predicting poor survival as well a promising therapeutic target.

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“…Previously, protein-coding genes were considered to be the main compartment of tumor suppressors (4). However, more recent studies have revealed that non-coding RNAs, including microRNA and long non-coding RNA (lncRNA) may also play a significant role in tumor suppression (5,6).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

2015

Oncology Letters

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Abstract. The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as significant protagonists of cellular functions. The dysregulation of lncRNAs has increasingly been linked to numerous human diseases, particularly cancers. Recent studies have demonstrated that the lncRNA growth arrest-specific transcript 5 (GAS5) was pervasively downexpressed in most human cancers compared with non-cancerous adjacent tissues including gastric, breast, lung and prostate cancer. In addition, patients with decreased GAS5 expression have a significantly poorer prognosis than those with higher expression. Furthermore, GAS5 is involved in the control of cell apoptosis, proliferation, metastasis, angiogenesis, DNA repair and tumor cell metabolism. This review provides an overview of the current knowledge concerning the role of GAS5 in tumor expression and biology function.

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Long non-coding RNAs in cancer progression

Cited by 210 publications

References 49 publications

Long non‐coding RNAs in rheumatoid arthritis

Long non‐coding RNAs in rheumatoid arthritis

Long non-coding RNA ANRIL predicts poor prognosis and promotes invasion/metastasis in serous ovarian cancer

Long non-coding RNA growth arrest-specific transcript 5 in tumor biology

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