Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy

Jiang, Feng; Zhou, Xiangyu; Jing, Huang

doi:10.1371/journal.pone.0152767

Cited by 101 publications

(62 citation statements)

References 26 publications

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“…Related miRNAs consist of miR-145, miR-205, miR-133 and miR-34 [31,32,34,36,38,48,49]. Among which, the miR-145 is the one who gains most attention in the field of linc-ROR.…”

Section: Linc-ror Functions As a Cerna To Regulate The Cell Progressesmentioning

confidence: 99%

“…The study provides evidences that linc-ROR prevented the degradation of miR-205 target genes, such as ZEB2, which is a EMT inducer. In addition, there are evidences that increased linc-ROR promotes the re-expression of fetal gene (ANP and BNP) and cardiomyocyte hypertrophy related genes via behaving as a ceRNA to inhibit the expression and function of miR-133 [49,63]. By suppressing miRNAs, linc-ROR may contribute to the regulation of genetic networks during development and tissue regeneration and may lead to new therapies for many diseases.…”

Section: Linc-ror Functions As a Cerna To Regulate The Cell Progressesmentioning

confidence: 99%

See 1 more Smart Citation

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

Pan

Li²,

Chen³

et al. 2016

Cell Physiol Biochem

120

100

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To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers. Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR), was first discovered in induced pluripotent stem cells (iPSCs), where it was controlled by the key pluripotency factors Oct4, Sox2 and Nanog. Linc-ROR has been shown to be dysregulated in many types of cancers, including breast cancer (BC), pancreatic cancer (PC), hepatocellular cancer (HCC), endometrial cancer (EC), and nasopharyngeal carcinoma (NPC). Also, linc-ROR functions as regulatory molecule in a large amount of biological processes. However, the underlying mechanisms of its contribution to carcinogenesis remain to be elucidated. In this review, we will emphasize on the characteristics of linc-ROR and their roles in different types of human cancers.

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“…Related miRNAs consist of miR-145, miR-205, miR-133 and miR-34 [31,32,34,36,38,48,49]. Among which, the miR-145 is the one who gains most attention in the field of linc-ROR.…”

Section: Linc-ror Functions As a Cerna To Regulate The Cell Progressesmentioning

confidence: 99%

Section: Linc-ror Functions As a Cerna To Regulate The Cell Progressesmentioning

confidence: 99%

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

Pan

Li²,

Chen³

et al. 2016

Cell Physiol Biochem

120

100

View full text Add to dashboard Cite

show abstract

“…Cardiac hypertrophy is related to a wide range of pathological and physiological elements, and its growth is closely correlated with the expression of the embryonic genes including ANP and BNP and improved protein synthesis [9,24]. In addition, it has been reported that lncRNAs The silence of HOXA9 outstandingly decreased the improved hypertrophic responses including the cell surface area, the mRNA and protein levels of ANP and BNP.…”

Section: Discussionmentioning

confidence: 99%

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis

Zhou

Feng

et al. 2018

Cardiorenal Med

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Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Nevertheless, the biological roles of lncRNA UCA1 and miR-184 in cardiac hypertrophy are scarcely reported. In this paper, qRT-PCR analysis exhibited that lncRNA UCA1 was highly expressed in mice heart treated with transverse aortic constriction (TAC) and the cardiomyocytes treated with phenylephrine (PE). On the contrary, miR-184 was downregulated under the same conditions. In addition, it was deduced that lncRNA UCA1 was reversely related with miR-184 in PE-triggered hypertrophic cardiomyocytes, confirmed by the Spearman correlation analysis. The knockdown of UCA1 or the overexpression of miR-184 lessened the enlarged surface area of cardiomyocytes and the elevated expressions of fetal genes (ANP and BNP) induced by PE. Later, it was determined that miR-184 was a direct target of UCA1, whereas the mRNA HOXA9 was a target of miR-184. Rescue assays indicated that UCA1 promoted the progression of cardiac hypertrophy through competitively binding with miR-184 to enhance the expression of HOXA9.

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“…Hence, the inhibition of CHAER expression could reduce cardiac hypertrophy and other types of heart dysfunctions. Moreover, another hypertrophic inducer is ROR (regulator of reprogramming) and functions as miR-133 sponge, since overexpression of miR-133 can reverse the pro-hypertrophic effect of ROR [81]. Conversely, a recent study discovered a class of anti-sense lncRNAs with cardio-protective effect, known as myosin heavy-chain associated RNA transcripts (MHRT or Myheart) [82].…”

Section: Lncrna-based Therapy For Cardiovascular Diseasesmentioning

confidence: 99%

Interactions between microRNAs and long non-coding RNAs in cardiac development and repair

Rotini

Martínez‐Sarrà

Pozzo

et al. 2018

Pharmacological Research

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Please cite this article as: Rotini Alessio, Martínez-Sarrà Ester, Pozzo Enrico, Sampaolesi Maurilio.Interactions between microRNAs and long noncoding RNAs in cardiac development and repair.Pharmacological Research http://dx.doi.org/10.1016/j.phrs. 2017.05.029 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical abstract.The regulation of cardiac development by miRs and lncRNAs, and their interaction in pathological setting. AbstractNon-coding RNAs (ncRNAs) are emerging players in muscle regulation. Based on their length and differences in molecular structure, ncRNAs are subdivided into several categories including small interfering RNAs, stable non-coding RNAs, microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs. miRs and lncRNAs are able to post-transcriptionally regulate many genes and bring into play several traits simultaneously due to a myriad of different targets. Recent studies have emphasized their importance in cardiac regeneration and repair. As their altered expression affects 3 cardiac function, miRs and lncRNAs could be potential targets for therapeutic intervention. In this context, miR-and lncRNA-based gene therapies are an interesting field for harnessing the complexity of ncRNA-based therapeutic approaches in cardiac diseases. In this review we will focus on lncRNA-and miR-driven regulations of cardiac development and repair. Finally, we will summarize miRs and lncRNAs as promising candidates for the treatment of heart diseases.

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Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy

Cited by 101 publications

References 26 publications

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers

lncRNA UCA1 Is a Novel Regulator in Cardiomyocyte Hypertrophy through Targeting the miR-184/HOXA9 Axis

Interactions between microRNAs and long non-coding RNAs in cardiac development and repair

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