Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m6A-dependent manner

Chen, Bo; Li, Na; He, Ling; Zhang, Sujing; An, Yonghui

doi:10.1007/s13577-021-00608-x

Cited by 25 publications

(15 citation statements)

References 35 publications

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“…Liu et al [ 38 ] identified the differentially expressed lncRNA in gastric cancer and found that the m6A modification of THAP7-AS1 by METTL3 enhanced its expression, and its high expression was associated with positive lymph node metastases and a poor prognosis in patients with gastric cancer. Bo et al [ 39 ] found that ILF3-AS1 increased the level of ILF3 m6A by recruiting the N6-methyladenosine (m6A) RNA methyltransferase METL3. Yan et al [ 40 ] observed that FOXC2-AS1 recruits the RNA methyltransferase NSUN2 to FOXC2 mRNA, increases its level of m5C, and associates with YBX1, indicating that FOXC2-AS1 acts as an oncogenic lncRNA by stabilizing FOXC2 mRNA in an m5C-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

Wang

Chen

et al. 2022

Disease Markers

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The role of 5-methylcytosine-related long noncoding RNAs (m5C-lncRNAs) in bladder cancer (BLCA) remains unclear. Here, we aim to study the prognostic value, gene expression characteristics, and correlation between the m5C-lncRNA risk model and the tumor microenvironment, immune infiltration, and tumor mutations in BLCA. After collecting BLCA patient RNA sequence transcriptome data, clinical information and mutation data from the Cancer Genome Atlas (TCGA) database, 17 m5C-related lncRNAs independently correlated with OS were obtained by Lasso and multivariate Cox regression analysis, and a risk model was constructed. Univariate Cox, multivariate Cox regression analysis, and the C-index curve proved that the risk model was a significant independent prognostic indicator for patients with BLCA. ESTIMATE and CIBERSORT indicated that the higher the number of immune cells and stromal cells in TME, the higher the prognostic risk. We found that in the low-risk group, the expression levels of immune cells that predicted a good prognosis were higher, including plasma cells, regulatory T cells, and CD 8 T cells. There is a negative correlation between TMB and risk score. The TMB of the low-risk group is significantly higher than that of the high-risk group. In conclusion, the m5C-related risk model is crucial to predict the prognosis of patients with BLCA.

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Section: Discussionmentioning

confidence: 99%

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

Wang

Chen

et al. 2022

Disease Markers

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“…Many researchers proved that lncRNAs acted actively in numerous cancers such as breast cancer, cervical cancer, and lung cancer [19][20][21]. Moreover, it was documented that many lncRNAs function as oncogenes in HCC, such as lncRNA CRNDE [22], lncRNA FOXP4-AS1 [23], and lncRNA ILF3-AS1 [24]. Thus, it is worthwhile to investigate the function of lncRNAs in HCC.…”

Section: Discussionmentioning

confidence: 99%

LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling

Zhou

Wang

Zhang

et al. 2022

JGLD

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Background: Hepatocellular carcinoma (HCC) is frequently diagnosed at late stages when curative treatments are no more appliable. Many studies have proved the active role of long non-coding RNAs (lncRNAs) in cancers’ biology; here, the functional role of lncRNA NCK1-AS1 in HCC was identified.Methods: Gene expression in tumor tissues of HCC was evaluated by examining online databases and 88 collected HCC samples from our hospital. The interactions of miR-22-3p with NCK1-AS1 and tyrosyl-tRNA synthetase (YARS) were tested by conducting bioinformatics analysis, luciferase report, and RNA pulldown experiments. CCK-8, colony formation, flow cytometry, wound healing, transwell experiments were used to dissect the role of the NCK1-AS1/miR-22-3p/YARS axis in HCC.Results: NCK1-AS1 was overexpressed in HCC cells and tissues. Functional assays depicted that depletion of NCK1-AS1 hampered malignant character of HCC cells. NCK1-AS1 controlled the availability of miR-22-3p, resulting in YARS upregulation. YARS was found to have a clinical value for HCC diagnosis. Moreover, rescue experiments revealed that miR-22-3p inhibition or YARS overexpression partially blocked the function of NCK1-AS1 deficiency in HCC cells. As for the downstream signaling pathway, we discovered that NCK1-AS1 activated PI3K/AKT signaling by the miR-22-3p/YARS axis.Conclusion: The present study verified that NCK1-AS1 could promote HCC progression via the miR-22-3p/YARS axis to activate PI3K/AKT signaling.

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“…Circ-ARL3 sponges miR-1305 and antagonizes the inhibition of miR-1305 on a group of target oncogenes, thereby promoting the progression of HBV + HCC (90); LncRNA ILF3-AS1 expression is increased in HCC tissues. ILF3-AS1 increases the methylation level of ILF3 by recruiting METTL3, thereby inhibiting degradation of ILF3 and ultimately promoting the proliferation, migration, and invasion of HCC cells (91). In HCC, METTL3 enhanced the stability of lncRNA NIFK-AS1 mRNA by increasing the methylation modification level of NIFK −AS1, resulting in increased expression of NIFK-AS1.…”

Section: Liver Cancermentioning

confidence: 99%

The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Lin

Man

et al. 2022

Front. Oncol.

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N6-methyladenosine (m6A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m6A modification process by affecting the expression of m6A-related enzymes. The interaction between m6A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m6A and non-coding RNAs in gastrointestinal tract cancers.

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Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m6A-dependent manner

Cited by 25 publications

References 35 publications

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling

The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

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